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Active substance(s): GLYCERYL TRINITRATE

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Deponit 5mg Patches

Ref: 0806/080316/1/F

(glyceryl trinitrate)
Patient Information Leaflet
Read all of this leaflet carefully before you start
using this medicine.
- Keep this leaflet. You may need to read it again.
- If you have further questions, please ask your
doctor or pharmacist.
- This medicine has been prescribed for you. Do not
pass it on to others. It may harm them, even if their
symptoms are the same as yours.
Your medicine is called Deponit 5mg Patches but
will be referred to as Deponit throughout the leaflet.

In this leaflet:
1 What Deponit is for
2 Before you use Deponit
3 How to use Deponit
4 Possible side effects
5 How to store Deponit
6 Further information

What Deponit is for

Deponit belongs to a group of medicines called
‘nitrates’. These are used to widen your blood
vessels and reduce the workload of your heart.
Deponit is used to prevent angina pectoris.
Angina attacks feel like a tight pain in your chest,
neck or arm and are a sign that your heart is not
getting enough oxygen for the amount of work it is

2 Before you use Deponit
Do not use Deponit if:
• You are allergic to glyceryl trinitrate or to any of
the other ingredients in Deponit (See section 6)
• You are taking medicines for failure to achieve
an erection such as Viagra. Using Deponit with
these medicines could cause a severe drop in
blood pressure and could lead to collapse and
unconsciousness, and may be fatal
• You have a condition in which your heart does
not pump enough blood around your body due
to obstruction of the arteries in the heart as in a
condition called aortic or mitral stenosis.
• You suffer from a heart condition which is
associated with low blood pressure leading to
• You suffer from low blood pressure
• You suffer from low blood volume
• You suffer from anaemia (low iron levels in your
• You have an eye disease called glaucoma
• You have a heart valve disorder
• You suffer from inflammation of the heart lining
• You suffer from increased fluid around the heart
(cardiac tamponade)
• You suffer from a heart condition called
hypertrophic obstructive cardiomyopathy
• You have ever had a serious head injury, cerebral
haemorrhage (bleeding in the brain) or a disease
which is accompanied by increased pressure on
the brain
• You have an acute angina attack. Your doctor will
give you a different medicine such as a GTN spray
for this.
• You are using riociguat, a medicine used in
treating pulmonary hypertension
If any of the above applies to you talk to your doctor.
If any of the above applies to you talk to your
Check with your doctor before using Deponit if:
• You have an underactive thyroid gland
• You have any diseases of the lungs, liver or
• You have recently had a heart attack or you suffer
from heart failure
• You suffer from hypoxaemia (insufficient oxygen
in your blood) due to lung disease, heart failure
or severe anaemia (low haemoglobin)
• You have hypothermia (very low body
• You are malnourished (severe lack of food).
• You have a condition called Angina pectoris
(chest pain).

• You have had a heart attack.
• You have a condition in which there is insufficient
blood flow to the brain (cerebral ischemia).
Taking other medicines
• Do not take Deponit with medicines for
failure to achieve an erection such as Viagra.
Using Deponit with these medicines could
cause a severe drop in blood pressure and
could lead to collapse and unconsciousness,
and may be fatal
Tell your doctor if you are taking any of the
following medicines:
• Medicines which are used to treat angina, heart
failure, or an irregular heartbeat. A blood condition
(methaemoglobinaemia) can occur when other
nitrate treatments are given at the same time. This
can result in breathing problems, anxiety, loss of
consciousness and heart attack.
• Medicines which reduce blood pressure
(e.g. beta-blockers, calcium channel blockers,
vasodilators, ACE inhibitors)
• Diuretics (water tablets)
• Tricyclic antidepressants (used to treat
• Neuroleptics (used to treat anxiety)
• Dihydroergotamine (used to treat migraine)
• Amifostine (drug used along with anticancer
drugs) and Aspirin should not be taken together
as they increase the blood pressure lowering
effect of Deponit.
• Sapropterine (Tetrahydrobiopterine, BH4)
• Any other medicine, including medicines obtained
without a prescription.
If any of the above applies to you, do not take
Deponit. Talk to your doctor.
Using Deponit with food and drink
Do not drink alcohol whilst using Deponit as it can
cause your blood pressure to drop. This may make
you may feel dizzy or faint.
Pregnancy and breast-feeding
If you are pregnant, trying to become pregnant or
breast feeding, ask your doctor for advice before
using Deponit.
Driving and using machines
Deponit 10 may make you feel dizzy, tired or have
blurred vision. If this happens to you, do not drive a
vehicle or operate machinery.

How to use Deponit

Always use Deponit exactly as your doctor has
Your doctor will choose the dose that is right
for you. Your dose will be shown clearly on
the label that your pharmacist puts on your
medicine. If it does not, or you are not sure, ask
your doctor or pharmacist.
Deponit is not suitable for children.
Adults and the Elderly
• Normally one patch per day is enough
• Your doctor may increase this to two patches
depending on how you respond to the medicine
• At the start of your treatment, put on a patch in
the morning
• Remove the patch before you go to bed
• You must have 8 to 12 hours each day without a
patch on. This will prevent you from becoming
tolerant to the medicine. If you do this it will
ensure the treatment remains effective
• Each morning put on a new patch.
When applying the patch you should always:
• Place the new patch on a different area of skin
• Allow several days to pass before applying a
fresh patch to the same area of skin.
Things to remember:
• Do not stretch the skin when putting a patch on
• Do not put the patch on a cut or reddened area of
• Do not pull the patch off the skin and then stick it
back on again.

How and where to apply the patch
• Choose a smooth area of skin to apply the patch.
The area should be hairless, to ensure good
contact of the patch with the skin. The chest,
upper abdomen, upper arm, shoulder or thigh is

Your hands and the skin where you will apply the
patch should be clean and dry. Do not use
powder or moisturiser.
Tear open the wrapper across the top, take out
the patch and hold it with the writing facing away
from you.
Fold the patch along the S-shaped cut so the
sides of the backing come apart.
Hold the patch on one side and peel off the
backing on the other side to expose the sticky
patch. Place the sticky side of the patch directly
onto the skin.
Peel off the remainder of the backing and press
down firmly with the palm of your hand.

If you use more Deponit than you should
If you accidentally use more Deponit than you
should, remove the patches straight away and
immediately go to your doctor or the nearest hospital
casualty department.
If you use more Deponit than you should,
you may have a fall in blood pressure. This may
make you feel dizzy, weak and light-headed on
standing. You may also be pale, sweat a lot,
have a weak pulse, rapid heart beats (tachycardia),
flushed skin, headache, feel sick or be sick,
In severe cases of overdose you may get an
increase of the pressure of the fluid around the

Uncommon side effects (affects less than 1 in 100
• Collapse sometimes with a slow heart beat and
• Very low blood pressure (severe hypotension)
where you are being sick, feeling sick, are
restless, have a pale skin and sweat a great deal.
This may lead to a worsening of the chest pain
you often get with angina
• Temporary low oxygen level in the blood
(temporary hypoxaemia). For people with heart
disease this may lead to low oxygen level in the
tissue surrounding the heart (myocardial hypoxia)
• A slight reddening, slight itching or burning
sensation on the skin where you have applied the
patch. This usually disappears after the patch
has been removed. Be sure to put your patch in a
differnt place each day.
• Allergic skin rash, which may be severe
• Flushing of the face
• Feeling sick
• Being sick
• Very red skin with scaling and thickened itchy
skin (exfoliative dermatitis)
• Heartburn.
Reporting of suspected adverse reactions
If you get any side effects, talk to your doctor or
pharmacist. This includes any possible side effects
not listed in this leaflet. You can also report side
effects directly via the national reporting system
listed below:
The Yellow Card Scheme
By reporting side effects, you can help provide
more information on the safety of this medicine.


If you forget to use Deponit
• If you forget to change your patch: Take the old
one off and put a new one on as soon as you
remember, then carry on as before.
• If you forget to apply a patch: Put a new one on
as soon as possible, then carry on as before.

How to store Deponit

Do not store above 25°C
Do not use Deponit after the expiry date shown
on the label. The expiry date refers to the last
day of that month.
If your medicine becomes discoloured or shows
any other signs of deterioration, consult your
pharmacist who will tell you what to do
Medicines should not be disposed of via
wastewater or household waste. Ask your
pharmacist how to dispose of medicines no longer
required. These measures will help to protect the

Do not take a double dose to make up for a missed
If you stop using Deponit
Do not stop using Deponit even if you feel better. If
you stop taking your medicine your condition may
get worse. Keep using Deponit until your doctor tells
you to stop.
If your doctor thinks you should stop taking Deponit
your dose will gradually be reduced.
Also if you are being transferred to another
treatment, your dose will be gradually reduced or
withdrawn and the overlapping treatment will be

Possible side effects

Like all medicines, Deponit can cause side effects,
although not everybody gets them.
Stop using Deponit and seek immediate medical
help if you have an allergic reaction. This
includes any of the following symptoms:
• Sudden wheeziness
• Difficulties in breathing
• Swelling of your eyelids, face or lips
• Rash or itching especially those covering your
whole body.
Very common side effects (affects more than 1 in
10 people)
• Headaches at the start of treatment. These
usually disappear after a few days of continuing
to use the patches. If necessary you can take
mild painkillers e.g. paracetamol.
Common side effects (affects less than 1 in 10
• Low blood pressure (hypotension) and
light-headedness upon standing which you may
notice as dizziness, drowsiness, rapid heart
beat (reflex tachycardia) and a feeling of
weakness at the start of treatment or when the
dosage is increased.

Further Information

What Deponit contains
Each patch contains 18.7mg of glyceryl trinitrate,
designed to release 5mg of glyceryl trinitrate in
Inactive ingredients: polyethylene, acrylate/vinyl
acetate copolymer and polypropylene.
What Deponit looks like and contents of the
Deponit is a white, translucent square patch with
round corners. Each patch is supplied in a foil
Each cardboard box contains 15 or 28 patches.
Manufacturer and Licence Holder
The patches are manufactured by Aesica
Pharmaceuticals GmbH, Monheim, Germany and
are procured from within the EU and repackaged by
the Product Licence Holder: Lexon (UK) Limited,
Unit 18, Oxleasow Road, East Moons Moat,
Redditch, Worcestershire, B98 0RE.
Deponit is a registered trademark of UCB Pharma


PL 15184/0806

Leaflet revision date: 08/03/16

Blind or partially sighted?
Is this leaflet hard to see or read?
Phone Lexon (UK) Limited,
Tel: 01527 505414 for help.

Ref: 0806/080316/1/B

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.