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Active substance(s): GLYCERYL TRINITRATE

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Patient Information Leaflet




Transdermal Patch
Glyceryl trinitrate 18.7 mg

Read all of this leaflet carefully before
you start using this medicine.
• Keep this leaflet. You may need to read
it again
• If you have further questions, please ask
your doctor or pharmacist
• This medicine has been prescribed for you.
Do not pass it on to others. It may harm
them, even if their symptoms are the same
as yours
• In this leaflet Deponit 5 transdermal patch
will be called Deponit 5.

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In this leaflet:
1. What Deponit 5 is for
2. Before you use Deponit 5
3. How to use Deponit 5
4. Possible side effects
5. How to store Deponit 5
6. Further information.

1. What Deponit 5 is for
Deponit 5 belongs to a group of medicines
called ‘nitrates’. These are used to widen
your blood vessels and reduce the workload
of your heart.
Deponit 5 is used to prevent angina pectoris.
Angina attacks feel like a tight pain in your
chest, neck or arm and are a sign that your
heart is not getting enough oxygen for the
amount of work it is doing.
2. Before you use Deponit 5
Do not use Deponit 5 if:
You are allergic to glyceryl trinitrate or to
any of the other ingredients in Deponit 5
(See section 6)
• You are taking medicines for failure to achieve
an erection such as Viagra. Using Deponit 5 with
these medicines could cause a severe
drop in blood pressure and could lead to
collapse and unconsciousness, and may
be fatal
• You have a condition in which your heart does
not pump enough blood around your body due
to obstruction of the arteries in the heart as in a
condition called aortic or mitral stenosis.
• You suffer from a heart condition which is
associated with low blood pressure leading to

You suffer from low blood pressure
You suffer from low blood volume
You suffer from anaemia (low iron levels
in your blood)
• You have an eye disease called glaucoma
• You have a heart valve disorder
• You suffer from inflammation of the heart lining
• You suffer from increased fluid around
the heart (cardiac tamponade)
• You suffer from a heart condition called
hypertrophic obstructive cardiomyopathy
• You have ever had a serious head injury,
cerebral haemorrhage (bleeding in the brain)
or a disease which is accompanied by
increased pressure on the brain
• You have an acute angina attack. Your
doctor will give you a different medicine
such as a GTN spray for this.
• You are using riociguat, a medicine used in
treating pulmonary hypertension
If any of the above applies to you talk to your
If any of the above applies to you talk to
your doctor.
Check with your doctor before using
Deponit 5 if:
• You have an underactive thyroid gland

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You have any diseases of the lungs, liver
or kidneys
You have recently had a heart attack or
you suffer from heart failure
You suffer from hypoxaemia (insufficient oxygen
in your blood) due to lung disease, heart failure
or severe anaemia (low haemoglobin)
You have hypothermia (very low body
You are malnourished (severe lack of food).
You have a condition called Angina pectoris
(chest pain).
You have had a heart attack.
You have a condition in which there is insufficient
blood flow to the brain (cerebral ischemia).

Taking other medicines
• Do not take Deponit 5 with medicines
for failure to achieve an erection such
as Viagra. Using Deponit 5 with these
medicines could cause a severe drop
in blood pressure and could lead to
collapse and unconsciousness, and
may be fatal
Tell your doctor if you are taking any of
the following medicines:
• Medicines which are used to treat angina,
heart failure, or an irregular heartbeat.
A blood condition (methaemoglobinaemia)

can occur when other nitrate treatments
are given at the same time. This can result
in breathing problems, anxiety, loss of
consciousness and heart attack.
which reduce blood pressure

(e.g. beta-blockers, calcium channel
blockers, vasodilators, ACE inhibitors)
• Diuretics (water tablets)
• Tricyclic antidepressants (used to treat
• Neuroleptics (used to treat anxiety)
• Dihydroergotamine (used to treat migraine)
• Amifostine (drug used along with anticancer
drugs) and Aspirin should not be taken together
as they increase the blood pressure lowering
effect of Deponit 5.
• Sapropterine (Tetrahydrobiopterine, BH4)
• Any other medicine, including medicines
obtained without a prescription.
If any of the above applies to you, do not take
Deponit 5. Talk to your doctor.
Using Deponit 5 with food and drink
Do not drink alcohol whilst using Deponit 5
as it can cause your blood pressure to drop.
This may make you may feel dizzy or faint.

Pregnancy and breast-feeding
If you are pregnant, trying to become pregnant
or breast feeding, ask your doctor for advice before
using Deponit 5.
Driving and using machines
Deponit 5 may make you feel dizzy, tired or
have blurred vision. If this happens to you, do
not drive a vehicle or operate machinery.
3. How to use Deponit 5
Always use Deponit 5 exactly as your doctor
has advised.
Your doctor will choose the dose that is right
for you. Your dose will be shown clearly on
the label that your pharmacist puts on your
medicine. If it does not, or
you are not sure, ask your doctor or
Deponit 5 is not suitable for children.
Adults and the Elderly
• Normally one patch per day is enough
• Your doctor may increase this to two
patches depending on how you respond
to the medicine
• At the start of your treatment, put on a
patch in the morning

Remove the patch before you go to bed
You must have 8 to 12 hours each day
without a patch on. This will prevent you
from becoming tolerant to the medicine.
If you do this it will ensure the treatment
remains effective
Each morning put on a new patch.

When applying the patch you should
• Place the new patch on a different
area of skin
• Allow several days to pass before
applying a fresh patch to the same
area of skin.
Things to remember:
• Do not stretch the skin when putting
a patch on
• Do not put the patch on a cut or reddened
area of skin
• Do not pull the patch off the skin and then
stick it back on again.

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How and where to apply the patch
• Choose a smooth area of skin to apply the
patch. The area should be hairless, to
ensure good contact of the patch with the
skin. The chest, upper abdomen, upper arm,
shoulder or thigh is suitable.

Your hands and the skin where you will
apply the patch should be clean and dry.
Do not use powder or moisturiser.
Tear open the wrapper across the top, take
out the patch and hold it with the writing
facing away from you.
Fold the patch along the S-shaped cut so
the sides of the backing come apart.
Hold the patch on one side and peel off
the backing on the other side to expose the
sticky patch. Place the sticky side of the patch
directly onto the skin.

Peel off the remainder of the backing and
press down firmly with the palm of your

If you use more Deponit 5 than you
If you accidentally use more Deponit 5 than
you should, remove the patches straight away
and immediately go to your doctor or the
nearest hospital casualty department.
If you use more Deponit 5 than you should,
you may have a fall in blood pressure. This may
make you feel dizzy, weak and light-headed on
standing. You may also be pale, sweat a lot,
have a weak pulse, rapid heart beats (tachycardia),
flushed skin, headache, feel sick or be sick,
In severe cases of overdose you may get an
increase of the pressure of the fluid around
the brain.
If you forget to use Deponit 5
• If you forget to change your patch: Take the
old one off and put a new one on as soon as
you remember, then carry on as before.
• If you forget to apply a patch: Put a new one
on as soon as possible, then carry on as before.
Do not take a double dose to make up for a missed

If you stop using Deponit 5
Do not stop using Deponit 5 even if you feel
better. If you stop taking your medicine your
condition may get worse. Keep using Deponit 5
until your doctor tells you to stop.
If your doctor thinks you should stop taking
Deponit 5 your dose will gradually be reduced.
Also if you are being transferred to another treatment,
your dose will be gradually reduced or withdrawn and
the overlapping treatment will be started.
4. Possible side effects
Like all medicines, Deponit 5 can cause side
effects, although not everybody gets them.
Stop using Deponit and seek immediate
medical help if you have an allergic
reaction. This includes any of the following
• Sudden wheeziness
• Difficulties in breathing
• Swelling of your eyelids, face or lips
• Rash or itching especially those
covering your whole body.
Very common side effects (affects more
than 1 in 10 people)
• Headaches at the start of treatment. These
usually disappear after a few days of continuing
to use the patches. If necessary you can take
mild painkillers e.g. paracetamol.

Common side effects (affects less than
1 in 10 people)
• Low blood pressure (hypotension) and
light-headedness upon standing which you may
notice as dizziness, drowsiness, rapid heart
beat (reflex tachycardia) and a feeling of
weakness at the start of treatment or when
the dosage is increased.
Uncommon side effects (affects less than
1 in 100 people)
• Collapse sometimes with a slow heart beat
and fainting
• Very low blood pressure (severe hypotension)
where you are being sick, feeling sick, are
restless, have a pale skin and sweat a great
deal. This may lead to a worsening of the chest
pain you often get with angina
• Temporary low oxygen level in the blood
(temporary hypoxaemia). For people with
heart disease this may lead to low oxygen level
in the tissue surrounding the heart
(myocardial hypoxia)
• A slight reddening, slight itching or burning
sensation on the skin where you have applied
the patch. This usually disappears after
the patch has been removed. Be sure to put
your patch in a different place each day.
• Allergic skin rash, which may be severe
• Flushing of the face

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Feeling sick
Being sick
Very red skin with scaling and thickened
itchy skin (exfoliative dermatitis)
• Heartburn.
Reporting of suspected adverse reactions
If you get any side effects, talk to your doctor or
pharmacist. This includes any possible side effects
not listed in this leaflet. You can also report side
effects directly via the national reporting system
listed below:
The Yellow Card Scheme
By reporting side effects, you can help provide
more information on the safety of this medicine.
5. How to store Deponit 5
Keep out of the reach and sight of children.
Do not use Deponit 5 after the expiry date shown
on the label. The expiry date refers to the last day
of that month.
Do not store above 25˚C.
Medicines should not be disposed of via
wastewater or household waste. Return all unused
medicine to your pharmacist.

6. Further information
What Deponit 5 contains
The active ingredient is glyceryl
trinitrate (18.7 mg).
The other ingredients are: acrylate/vinyl acetate
copolymer (adhesive matrix); polypropylene
(backing foil); and polyethylene (siliconised
release liner).

If this leaflet is difficult to read and
you would like it in a
different format, please contact
Merus Labs Luxco II S.à r.l.
26-28, rue Edward Steichen
L-2540 Luxembourg

What Deponit 5 looks like
Deponit 5 is a white, translucent square patch
with round corners. It has “Deponit 5” marked on
the outer face. Each patch is supplied in
a foil pouch. There are 28 patches in a box.
Marketing Authorisation Holder
Merus Labs Luxco II S.à r.l.
26-28, rue Edward Steichen
L-2540 Luxembourg
Aesica Pharmaceuticals GmbH,
Alfred-Nobel-Straße 10,
D-40789 Monheim, Germany.
This leaflet was last updated October 2016

4020907 11/1953 4000

26/04/2017 09:58


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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.