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COSURIC/ALLOPURINOL 300MG TABLETS

Active substance(s): ALLOPURINOL

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PATIENT INFORMATION LEAFLET

COSURIC/Allopurinol
100 mg & 300 mg Tablets
PLEASE READ THIS LEAFLET CAREFULLY BEFORE
YOU START TAKING THIS MEDICINE.
KEEP THIS LEAFLET UNTIL YOU HAVE FINISHED ALL
THE PRESCRIBED COURSE OF COSURIC
IF YOU HAVE ANY QUESTIONS CONCERNING YOUR
MEDICINE ASK YOUR DOCTOR OR PHARMACIST FOR
MORE INFORMATION
What is in your medicine?
The name of this medicine is Cosuric. Each tablet contains
the active ingredient Allopurinol BP, together with the
following inactive ingredients; povidone, polyethylene
glycol 6000, dextrose monohydrate, stearic acid, purified
water.
Cosuric is available in two strengths, 100 mg & 300 mg.
Cosuric tablets 100 mg contain Allopurinol BP 100 mg.
Cosuric tablets 300 mg contain Allopurinol BP 300 mg.
Cosuric 100 mg are white round tablets marked COSURIC
100.
Cosuric 300 mg are white round tablets marked COSURIC
300.
Both strengths of Cosuric tablets are available in
containers of 16, 21, 28, 30, 50, 56, 60, 84, 90, 112, 120,
140, 150, 168, 180, 250, 1000, 5000, 50000 tablets, and in
blister packs of 16, 21, 50, 56, 60, 84, 90, 100, 112, 120,
140, 150, 168, 180 tablets.
The name and address of the Product Licence holder is:
Chelonia Healthcare Limited
Boumpoulinas 11, 3rd Floor, Nicosia, P.C. 1060, Cyprus
The Manufacturer of Cosuric is:
DDSA Pharmaceuticals Ltd.,
Chatfield Road, off York Road, London SW11 3SE
The active ingredient in Cosuric tablets, Allopurinol, is
known as a xanthine-oxidase inhibitor and belongs to a
group of medicines known as enzyme inhibitors.
Why have you been prescribed Cosuric?
This medicine is used for the treatment and prevention of
kidney stones, and for the prevention of gout.
If you are not sure why you have been prescribed Cosuric,
then please ask your doctor.
Before taking your medicine
Before taking this medicine, tell your doctor:

• If you have ever had any unusual or allergic reactions
to Allopurinol or any of the other ingredients contained
in the medicine.
• If you suffer from attacks of gout.
• If you have kidney problems.
• If you have liver problems.
• If you are pregnant or planning a pregnancy.
• If you are breast-feeding.
• If you are allergic to any foods, preservatives or dyes.
Serious skin rashes (Hypersensitivity syndrome, StevensJohnson syndrome, toxic epidermal necrolysis) have been
reported with the use of allopurinol. Frequently, the rash
can involve ulcers of the mouth, throat, nose, genitals and
conjunctivitis (red and swollen eyes). These serious skin
rashes are often preceded by influenza-like symptoms
fever, headache, body ache (flu-like symptoms). The rash
may progress to widespread blistering and peeling of the
skin.
These serious skin reactions can be more common in
people of Han Chinese or Thai origin.
If you develop a rash or these skin symptoms, stop taking
Cosuric and contact your doctor immediately.
Use in pregnancy & while breast-feeding
If you are pregnant or breast-feeding contact your doctor
before taking this medicine.
Can you take Cosuric with other medicines?
There are some medicines that can interfere with Cosuric. It
is very important to tell your doctor or pharmacist about
all the medicines that you are taking, whether or not any
medicines were prescribed by your doctor or bought
without a prescription from the pharmacy or elsewhere.
Your doctor will be able to identify medicines you should not
take with Cosuric.
It is important to tell your doctor:
• If you are taking anticoagulants (blood thinners) such
as warfarin or nicoumalone.
• If you are taking chlorpropamine (to treat diabetes).
• If you are taking Non-Steroidal Anti-Inflammatory Drugs
such as azathioprine and 6-mercaptopurine.
• If you are taking cyclophosphamide used in the
treatment of leukaemia and lymph gland problems.
When and how to take these tablets
The tablets are to be taken by mouth and only in the doses
prescribed by your doctor. Do not take more and do not
take more often. Try to take your medication at the same
time every day. The tablets should be taken with water and
after a meal. You should try to drink about 2 litres of fluid a
day while you are taking COSURIC tablets.
You will be prescribed the lowest dose necessary to control
your symptoms. Do not stop taking your medicine or
change the dose unless your doctor tells you to.

Usual dosages are stated below:
Adults: Initially 100 mg per day. This dose may be
increased depending on how well you respond to
treatment. Usual maintenance dose in mild conditions 100200 mg daily; in moderately severe conditions 300-600 mg
daily, in severe conditions 700-900 mg daily. Doses more
than 300 mg should be taken in divided doses.
Children: The daily dose is 10-20 mg per kilo bodyweight.
Elderly: The dose should be maintained at the smallest
necessary level.
Dosages will be reduced if you have kidney or liver
problems.
What to do if too many tablets are taken at the same
time
If you accidentally take more tablets than recommended
contact your nearest doctor or hospital casualty department
at once. Take any remaining tablets with you and keep in
the original container or packaging so that they can be
identified.
What if you miss a dose?
If you miss a dose, skip the missed dose and go back to
your regular dosage schedule. Do not double the dose. If
you feel that this medicine is not working as well after you
have taken it for a short time (3-4 days) do not increase the
dose, instead check with your doctor.
What side effects can Cosuric have?
If you experience any of the following, stop your
tablets and tell your doctor immediately:
Rare (affects less than 1 in 1000 people)
• fever and chills, headache, aching muscles (flu-like
symptoms) and generally feeling unwell
• any changes to your skin, for example ulcers of the
mouth, throat, nose, genitals and conjunctivitis (red and
swollen eyes), widespread blisters or peeling
• Serious hypersensitivity reactions involving fever, skin
rash, joint pain, and abnormalities in blood and liver
function tests (these may be signs of a multi-organ
sensitivity disorder)
Skin reactions are the most common side effect of Cosuric,
and can occur at any time during treatment. These
reactions can take the form of a rash, peeling or flaky skin,
or dry scaly skin.
Cosuric can cause stomach problems such as nausea and
vomiting, a spinning sensation known as vertigo,
drowsiness, visual and taste disorders, high blood
pressure, hair loss, liver disorders, pins and needles,
various blood disorders.

Other reported side effects include feeling weak, difficulty
with walking, sleepiness, coma, depression, loss of
movement, cataract, inflammation of the mouth (stomatitis),
changed bowel habit, sexual problems, infertility, diabetes,
boils, discoloured hair, angina (chest pain), reduction in
heart rate, puffiness due to water retention, swelling of all
soft tissues, changes in the composition of blood and urine,
swollen breasts.
If you notice any of the above reactions or side effects
or if you notice other unusual or worrying changes to
your health contact your doctor.
Storing your medicine
You must keep this medicine in a safe place where children
cannot get at it. Your medicine could harm them.
Keep your medicine in a dry place, below 25°C. Keep the
tablets in the container in which they were given to you.
If your doctor tells you to stop the treatment, return any
remaining tablets to the pharmacist.
On the container you will find the words “expiry date”
followed by numbers indicating the day, month and year.
This is the date after which the medicine is no longer fit for
use. Do not use the medicine after this date but return it to
your doctor or pharmacist.
A reminder
REMEMBER this medicine is for you. Never give it to
someone else, even if their symptoms are the same as
yours.
This leaflet does not contain the complete information
about your medicine. If you have any questions or are not
sure about anything, ask your doctor or pharmacist who
have access to additional information.
PL No’s: 33414/0002 & 33414/0003
This leaflet was revised in November 2012

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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