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CO-TRIAMTERZIDE TABLETS

Active substance(s): HYDROCHLOROTHIAZIDE / TRIAMTERENE / HYDROCHLOROTHIAZIDE / TRIAMTERENE / HYDROCHLOROTHIAZIDE / TRIAMTERENE

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Co-Triamterzide Tablets BP
(Co-triamterzide)
Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.
• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor, or pharmacist
or nurse.
• This medicine has been prescribed for you only. Do not pass it
on to others. It may harm them, even if their signs of illness are
the same as yours.
• If you get any side effects, talk to your doctor, or pharmacist or
nurse. This includes any possible side effects not listed in this
leaflet. See section 4.
In this leaflet:
1. What Co-triamterzide Tablets are and what they are used for
2. What you need to know before you take Co-triamterzide
Tablets
3. How to take Co-triamterzide Tablets
4. Possible side-effects
5. How to store Co-trimterzide Tablets
6. Contents of the pack and further information
1. WHAT CO-TRIAMTERZIDE TABLETS ARE AND WHAT
THEY ARE USED FOR
Co-triamterzide Tablets belong to a group of medicines called
diuretics. The medicine works by increasing the amount of urine
passed by your kidneys, so removing excess water from the body
and also reducing blood pressure.
Co-triamterzide Tablets are used for the treatment of high blood
pressure and also for the treatment of water retention in heart failure
or liver disease.
2. WHAT YOU NEED TO KNOW BEFORE YOU TAKE
CO-TRIAMTERZIDE TABLETS
Do not take Co-triamterzide if you:
• Have had an allergic (hypersensitive) reaction with symptoms of
a rash, itching or shortness of breath to triamterene or
hydrochlorothiazide or other sulphonamide derived drugs or any
excipients (see Section 6)
• Suffer from kidney failure or liver disease
• Suffer from uncontrolled diabetes leading to ketoacidosis
• Suffer from Addison’s disease, an underactive adrenal gland
• Are already taking potassium supplements or ACE inhibitors
(see Section 2, Other medicines and Co-triamterzide)
• Have been told by your doctor that you have high potassium in
your blood.
• Have been told by your doctor you have high calcium in your
blood (Hypercalcaemia).
Warnings and precautions
Talk to your doctor, or pharmacist or nurse before taking these tablets if you:
• Have been told by your doctor that you have low potassium in
your blood
• Are over 65 years as your doctor may give you a blood test
• Have kidney problems as you may need a blood test
• Are already taking NSAIDs (non-steroidal anti-inflammatory
drugs) as your doctor may give you a blood test
• Have cirrhosis of the liver or reduced liver function
• Have gout
• Have diabetes
• Have pancreatitis
• Have systemic lupus erythematosus
• Need a blood test for thyroid function or folic acid levels.
If you are over 65 years old, have kidney problems or are also taking an NSAID (Non-Steroidal Anti-inflammatory Drug) then your
doctor will see you regularly to monitor your treatment and you may
have to have blood tests.
Other medicines and Co-triamterzide
Are you taking any of the following medicines?
• Other medicines used for the treatment of high blood pressure
(e.g. an “ACE” inhibitor, another thiazide diuretic, loop diuretics,
renin inhibitors, “Beta-blocker” or “Alpha-blocker”)
• Corticosteroids (steroid hormones) or ACTH
(adrenocortiocotropic hormone)
• Potassium supplements
• Cholestyramine or colestipol (used to help lower cholesterol
level)
• Non-steroidal anti-inflammatory drugs (for the treatment of
arthritis and other painful conditions e.g. ibuprofen, aspirin)
• Medicines for diabetes (e.g. insulin, chlorpropamide)

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Carbamazepine (to treat epilepsy)
Lithium (for the treatment of depression)
Medicines for heart failure or palpitations/irregular heart beat
Medicines containing calcium or vitamin D (also sometimes
called calciferol or ergocalciferol for the treatment of soft bones)
Steroid therapy (for the treatment of allergic and inflammatory
disorders e.g. prednisolone)
Trilostane (for treatment of Chushing’s Syndrome)
An ulcer healing drug containing carbenoxolone
Ciclosporin or tacrolimus (used to prevent rejection of an organ
following transplant)
Allopurinol (to treat gout)
Toremifene (an artificial hormone)
Amphoteracin or fluconazole (to treat fungal infections)
Medicines for respiratory diseases (e.g. theophylline)
Taking alcohol, barbiturates or narcotics with this medicine may
lead to orthostatic hypotension
There is an increased risk or arrhythmias associated with certain
medicines that when taken with Co-triamterzide may cause
electrolyte disturbances such as cardiac glycosides, amisulpride,
atomoxetine, pimozide, sotalol, sertindole and thioridazine
Cisplatin (used in chemotherapy)
Muscle relaxants (such as baclofen and tizanidine)
Oestrogen and oral contraceptives (e.g. drospirenone)
Antidepressants such as amitriptyline and reboxetine, and also
Monoamine Oxidase Inhibitors (MAOIs) such as phenelzine
Sympathomimetics used to stimulate the heart, e.g. dopamine
and to treat asthma, e.g. salbutamol.

Please tell your doctor or pharmacist if you are taking or have
recently taken any other medicines, including medicines obtained
without a prescription.
If you are already taking another medicine to reduce your blood
pressure, your doctor may have reduced the dose of that medicine
before you start taking the Co-triamterzide Tablets. If your doctor
decides that you should take Co-triamterzide and an ACE inhibitor
at the same time, your condition is likely to be checked regularly.
If you see another doctor or go into hospital, tell them what medicines you are taking. This is important if you have an operation
because Co-triamterzide can interfere with medicines used during an
operation to relax muscles.
Taking Co-triamterzide with food and drink
The tablets should be swallowed with a drink of water after meals.
Pregnancy and breast-feeding
Ask your doctor or pharmacist before taking any medicine during
pregnancy and breast-feeding.
Driving and using machines
This medicine may cause some patients to feel weak, dizzy and have
headaches. DO NOT drive or operate machinery if it has this effect
on you.
Important information about some of the ingredients of
Co-triamterzide Tablets
Co-triamterzide Tablets contain Sunset Yellow (E110) which can
cause allergic reactions including asthma. Allergy is more common
if you already are allergic to aspirin.
These tablets also contain Lactose. Patients with rare hereditary
problems of galactose intolerance, the Lapp lactase deficiency or
glucose galactose malabsorption should not take this medicine.
3. HOW TO TAKE CO-TRIAMTERZIDE TABLETS
Always take Co-triamterzide exactly as your doctor has told you.
You should check with your doctor or pharmacist if you are not sure.
The usual doses of this medicine are given below. Check with
your doctor if you are not sure why you have been prescribed this
medicine.
For the treatment of high blood pressure: The usual starting dose is
one tablet a day (after breakfast). Your doctor may increase your
dose if necessary.
For the treatment of oedema: The usual starting dose is one tablet
twice a day, after meals. Your doctor may increase your dose if
necessary.
Co-triamterzide Tablets are not recommended for children.
These are the usual doses. Your doctor may prescribe different doses
to these. The label on the bottle will tell you what dose you should
take and for how long. If you are still not sure ask your doctor or
pharmacist.
If you take more Co-triamterzide Tablets than you should
Too many tablets at once may make you unwell. Contact
your doctor or your nearest casualty department at once if you have
taken too many tablets.
If you forgot to take Co-triamterzide Tablets
Do not worry. Take the missed dose as soon as you remember.
However, if it is almost time for your next dose, leave out the missed
dose and take your next dose at the right time.
Do not take a double dose to make up for a forgotten dose.

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If you have any further questions on the use of this product, ask your
doctor or pharmacist.
4. POSSIBLE SIDE EFFECTS
Like all medicines, Co-triamterzide can cause side effects, although
not everybody gets them.
If you experience any of the following for the first time after starting
to take this medicine, STOP taking the tablets and tell your doctor
immediately, these may be signs of an allergic reaction:


Serious allergic reaction - signs may include skin rashes, itching
or hives, swelling of the face, lips, tongue or other parts of the
body, difficulty breathing, feeling faint or dizzy.
• Serious skin reactions such as Toxic Epidermal Necrolysis. Symptoms include flu like symptoms e.g. fever, cough, sore throat and
runny nose for 2-3 days which develops into excessive peeling
of the skin.
• Other serious reactions include Systemic Lupus Erythmatous
where symptoms include swollen or aching joints, skin rash
which is usually on the face, weight change, sun or light sensitivity, hair loss and ulcers which usually occur in the mouth or
the nose.
Other unwanted effects which may occur are:
• Feeling sick (nausea), being sick (vomiting), dry mouth, severe
abdominal pain (acute pancreatitis), diarrhoea, stomach discomfort.
• Muscle cramps.
• Weakness, thirst, fever.
• This medicine can cause increased blood levels of cholesterol,
and also a waste product produced by the body called urea,
which may lead to gout. It can also alter the blood levels of minerals such as sodium, calcium and potassium. These will
be picked up in a blood test by your doctor.
• Rash, sensitivity of the skin to sunlight or artificial light (photosensitivity).
• Inflammation of the blood vessels (vasculitis - symptoms include
fever, weight loss, fatigue, a rapid pulse and aches and pains that
are difficult to pinpoint).
• Gout (attacks of pain or swelling in more than one joint).
• Metabolic acidosis (where the body produces excessive acid).
Symptoms of metabolic acidosis include chest pain, pounding
heat beat (palpitations) and headache.
• Glucose in the urine (Glycosuria).
• Increased levels of sugar in the blood (hyperglycaemia).
• Kidney failure which is reversible on stopping this medicine, due
to a disorder known as interstitial nephritis or acute interstitial
nephritis (a disorder where spaces between the kidney tubules
become swollen or inflamed). Reversible kidney failure can
also occur due to an interaction between triamterene and some
NSAIDs. Kidney or urinary stones.
• Changes in the types and numbers of blood cells. These will be
picked up during a blood test by your doctor.
• Breathing difficulties including inflammation of lung tissue with
a fever and cough (pneumonitis and interstitial pneumonitis),
build up of fluid in the lungs (pulmonary oedema).
• Headache, restlessness and dizziness.
• Temporary blurring of vision and yellowing of vision
(xanthopsia).
• Thickening of the blood vessel walls (Vasculitis necrotising)
symptoms include fever, chills, tiredness, weight loss, abnormal
skin tissue, muscle and joint pain and tingling in the body.
• Low blood volume (hypovolaemia).
• Lowering of blood pressure.
• Swelling in the mouth (Sialoadenitis).
• Yellowing of the skin and/or whites of the eyes (Jaundice).
• Serum sickness. This is a type of allergic reaction with symptoms
such as rashes, itching, joint pain fever, swollen lymph nodes and
tiredness.
• Your urine may look blue under certain light.

stated on the label. The expiry date refers to the last day of that
month.
Medicines should not be disposed of via waste water or household
waste. Ask your pharmacist how to dispose of medicines no longer
required. These measures will help to protect the environment.
6. CONTENTS OF THE PACK AND FURTHER INFORMATION
What Co-triamterzide Tablets contains
The active substances are 50mg of triamterene and 25mg of hydrochlorothiazide as the active ingredients (together known as
Co-triamterzide).
The other ingredients are:
Lactose
Modified cellulose gum
Povidone
Microcrystalline cellulose
Magnesium stearate
Purified stearate
Purified talc
Sunset yellow (E110)
What Co-triamterzide Tablets look like and contents of the pack
Description:
Co-triamterzide Tablets are round and peach coloured, with a break
line on one side and a pestle and mortar logo on the other side.
Contents of pack: Blister pack
The tablets are supplied to your pharmacist in packs containing
28, 30, 50, 100, or 500 tablets, who will then provide you with the
required number of tablets as prescribed by your doctor (not all pack
sizes may be marketed).
This leaflet does not contain all the information about this medicine. If you have any questions or are not sure about anything,
ask your doctor or pharmacist.
Marketing Authorisation Holder and Manufacturer:
MA Holder:
Co-Pharma Limited
Unit 4, Metro Centre,
Tolpits Lane, Watford,
Herts. UK,
WD18 9SS
Tel: 01923 255580
Fax: 01923 255581
Manufacturer:
Haupt Pharma Berlin GmbH,
Gradestrafle 13 Moosrosenstrafle 5and Britzer Damm 120
12347 Berlin
Germany
This medicinal product is authorised in the Member States of
the EEA under the following names:
Not applicable
This leaflet was last revised in 07/2015

Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse.
This includes any possible side effects not listed in this leaflet. You
can also report side effects directly via the Yellow Card Scheme at:
www.mhra.gov.uk/yellowcard
By reporting side effects you can help provide more information on
the safety of this medicine.
5. HOW TO STORE CO-TRIAMTERZIDE TABLETS
Keep out of the sight and reach of children.
Store below 25°C. Store in the original container.
Do not use Co-triamterzide Tablets after the expiry date which is

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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