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CO-TENIDONE 50/12.5 MG TABLETS

Active substance(s): ATENOLOL / CHLORTALIDONE

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Patient Information Leaflet

CO-TENIDONE 50/12.5MG TABLETS
CO-TENIDONE 100/25 MG TABLETS
(Atenolol & Chlortalidone)

This medicine will be called Co-tenidone Tablets
in this leaflet.
Read all of this leaflet carefully before you start
taking this medicine.
• Keep this leaflet. You may need to read it again.
• This medicine is only for you. Do not give it to anyone
else to take. It may harm them, even if their
symptoms are the same as yours.
• If you have any further questions, please ask your
doctor or pharmacist.
• If any of the side effects gets serious, or if you notice
any side effects not listed in this leaflet, please tell
your doctor or pharmacist.
In this leaflet:
1. What Co-tenidone Tablets are and what they are used
for
2. Before you take Co-tenidone Tablets
3. How to take Co-tenidone Tablets
4. Possible side effects
5. How to store Co-tenidone Tablets
6. Further information

Front of leaflet - 297mm

1. What Co-tenidone Tablets are and what
they are used for
These tablets are available in two different strengths and your
doctor will have decided which is the most suitable for you.
Co-tenidone 50/12.5 mg Tablets contain 50 mg of atenolol
and 12.5 mg of chlortalidone as the active ingredients.
Co-tenidone 100/25 mg Tablets contain 100 mg of atenolol
and 25 mg of chlortalidone as the active ingredients.
Atenolol belongs to a group of medicines known as beta
blockers which work on receptors in the heart to lower blood
pressure, and chlortalidone belongs to a group of medicines
known as diuretics which work by increasing the amount of
urine passed (a diuretic action), also helping to lower blood
pressure.
Co-tenidone Tablets are used to treat hypertension (high blood
pressure).

2. Before you take Co-tenidone Tablets
Some people must not take these tablets.
Do not take these tablets if you:
• Know you are allergic to atenolol, chlortalidone or to any of
the other ingredients (these are listed in section 6). (An
allergic reaction may be recognised as shortness of breath,
blocked nose, rash, itching, swollen face or lips)
• Have heart problems such as bradycardia or sick sinus
syndrome (causing slow or abnormal heart rhythms), second
or third degree heart block, uncontrolled heart failure or
cardiogenic shock
• Suffer from low blood pressure or you have very poor
circulation
• Have phaeochromocytoma (tumour of the adrenal gland)
unless you are being treated with another medicine for this,
or you have metabolic acidosis (too much acid in the body)
• Suffer from hypercalcaemia (an unusually high level of
calcium in the blood), hypokalaemia (low level of potassium
in the blood), hyponatraemia (low level of sodium in the blood)
or hyperuricaemia (high levels of uric acid in the blood)
• Are pregnant or breastfeeding
• Have Addison’s disease (a condition in which the adrenal
gland does not work properly causing weakness, tiredness,
weight loss and low blood pressure)

You must be especially careful if you:
• Have ever had asthma or wheezing unless you have
discussed these symptoms with the prescribing doctor.
• Have heart failure which is being controlled, first degree
heart block or you suffer from heart disease
• Suffer from portal hypertension (high blood pressure in the
large vein to the liver)
• Have myasthenia gravis (a disease causing muscle weakness)
• Suffer from diabetes
• Suffer from hyperthyroidism (an overactive thyroid gland)
• Suffer from Prinzmetal’s angina
• Are prone to allergic reactions
• Have impaired liver or kidney function
• Suffer from poor circulation.
If any of the conditions above apply to you, please discuss
your treatment with your doctor before taking this medicine.
Taking other medicines
Co-tenidone Tablets and other medicines you may be taking
may affect how each other work. Make sure your doctor knows
if you are taking any of the following:
• Other medicines being used to treat high blood pressure or
angina such as verapamil, diltiazem or nifedipine
• Medicines used for heart problems such as digoxin,
disopyramide or amiodarone
• Adrenaline (heart stimulant)
• Baclofen (a muscle relaxant)
• Insulin and oral medicines used in the treatment of diabetes
• Medicines used for pain relief such as ibuprofen or indometacin
• Medicines containing lithium (for treating depression)
• Clonidine (used in high blood pressure or migraine). Do not
stop taking clonidine unless instructed by your doctor. If you
need to stop taking it your doctor will give you careful
instructions on how to do this.
• Medicines to treat nose or sinus congestion or other cold
remedies (including those you can buy in the pharmacy).
• Betaxolol, carteolol, levobunolol and timolol (eye drops for
glaucoma).
Always tell your doctor or pharmacist about all the medicines
you are taking. This means medicines you have bought yourself
as well as those you have on prescription from your doctor.
Other special warnings
If you are having an operation requiring an anaesthetic, you
must ensure the doctor in charge is aware you are taking
Co-tenidone Tablets.
Your doctor may take blood samples whilst you are taking this
medicine, particularly if you are elderly, on a low potassium
diet, being treated for cardiac failure, or you have a stomach
problem.
Driving and using machinery
Co-tenidone Tablets may occasionally make some patients feel
dizzy or tired. Do not drive or operate machinery if they have this
effect on you. If you feel dizzy or tired when taking this medicine,
ask your doctor for advice.
Pregnancy and breast-feeding
Do not take Co-Tenidone if you are pregnant or trying to get
pregnant. Do not take Co-Tenidone if you are breast-feeding.

3. How to take Co-tenidone Tablets
The tablets should be swallowed with a drink of water.
Your doctor will decide what dose you need to take. Always take
the tablets exactly as the doctor has told you. The dose will be
on the pharmacist’s label. If you are not sure, ask your doctor or
pharmacist. Carry on taking them for as long as you have been
told unless you have any problems. In that case, check with
your doctor.
The usual dose is as follows:
Adults: Take one tablet daily.
Children: Your medicine must not be given to children.
People with kidney problems
If you have problems with your kidneys, your doctor may give
you a lower dose or ask you to take this medicine less often.

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If you take more tablets than you should
You should contact your doctor or go to your nearest hospital
casualty department immediately. Take your tablets or the
pack with you so that the doctor knows what you have taken.
If you forget to take a dose of Co-tenidone Tablets
If you miss a dose, take the missed dose as soon as you
remember unless it is nearly time for your next dose. Do not
take a double dose to make up for the forgotten dose; just
carry on with the normal routine.
If you stop taking Co-Tenidone
Do not stop taking Co-Tenidone without talking to your doctor.
In some cases, you may need to stop taking it gradually.

Back of leaflet - 297mm

4. Possible side effects
Co-tenidone Tablets are suitable for most people, but, like all
medicines they can sometimes cause side effects.
Some side effects can be serious.
Stop taking the tablets and tell your doctor straightaway if
you notice any of the following effects:
• Raised lumps on your skin (weals) or swelling of your face,
lips, mouth, tongue or throat.
• Shortness of breath, wheezing or breathing difficulties (may
be more likely to occur in patients who have asthma or a
history of an asthmatic condition)
• Skin rash, hives, itching or other serious skin reactions.
These may be signs of a severe allergic reaction.
Tell your doctor straight away if you notice any of the
following effects:
• Cough, coughing up blood, high temperature, excessive
sweating, anxiety, pale skin, problems in urinating, lower back
pain, swelling (particularly of the ankles), high blood pressure,
increased skin sensitivity to sunlight. (These may be signs of
conditions caused by an allergic reaction)
• Slow or irregular heartbeat, dizziness or fainting upon standing
up (caused by very low blood pressure), increased shortness
of breath or ankle swelling. (These may be symptoms of heart
or circulatory problems and worsening of heart failure)
• Severe pain in the abdomen and back (indicating
inflammation of the pancreas)
• Fever, tiredness and sometimes abnormal bleeding. (These
may be symptoms of a blood disorder which may make
infections more likely)
• Muscle weakness or spasms, twitching, abnormal heart
rhythm, confusion, fits, coma, loss of appetite, feeling or
being sick, constipation and abdominal pain.
The following side effects have also been reported:
Less than 1 in 10 people have experienced:
• Nausea and stomach/gastro-intestinal disturbances
• Weariness or tiredness
• Unusually high levels of uric acid in the blood
• Impaired glucose tolerance
• Cold hands and feet.
• You may notice that your pulse rate becomes slower while
you are taking the tablets. This is normal, but if you are
concerned please tell your doctor about it.
• Changes in the amount of certain substances in your blood.
It can cause:
- higher levels of sugar (glucose) than normal,
- low levels of sodium, which may cause weakness, being
sick (vomiting) and cramps,
- low levels of potassium, an increase in the amount of
uric acid.
Your doctor may take blood samples every so often to check
on these levels.
Less than 1 in 100 people have experienced:
• Sleep disturbances; increased transaminase levels.
Less than 1 in 1000 people have experienced:
• Pancreatitis (inflammation of a large gland behind the stomach).
• A reduced number of white blood cells
• Mood changes, changes in personality, hallucinations,
nightmares, confusion
• Dizziness, headache, tingling or numbness in the skin (like
pins and needles)
• Problems with vision, dry eyes; dry mouth

• Hair loss, skin rash or a skin disorder resembling psoriasis
(red scaly patches on the skin) or worsening of psoriasis
• Impotence (inability to achieve or maintain an erection)
• Numbness and spasm in your fingers which is followed by
warmth and pain (Raynaud’s disease).
• Jaundice (causing yellowing of your skin or the whites of your eyes).
• Bruising more easily or purplish marks on your skin.
• Pain and/or tightening of the muscles in the calf, thigh or
buttock during walking or exercise.
Less than 1 in 10,000 people have experienced:
• Increased levels of a type of antibody (known as ANAs) in
the blood.
• Changes to some of the cells or other parts of your blood.
Other side effects reported include:
• Feeling of dizziness or spinning;
• Changes in blood lipid (fat) levels, raised levels of glucose
in the blood
• Gout (symptoms include painful and swollen joints).
Not known (cannot be estimated from data available)
• Constipation.
Conditions that may get worse
If you have any of the following conditions, they may get worse
when you start to take your medicine. This happens rarely
affecting less than 1 in 1,000 people:
- Psoriasis (a skin condition).
- Being short of breath or having swollen ankles (if you have
heart failure).
- Asthma or breathing problems.
- Poor circulation.
If any of the side effects gets serious, or if you notice any
side effects not listed in this leaflet, please tell your doctor
or pharmacist.
You can also report side effects directly via the Yellow Card
Scheme at: www.mhra.gov.uk/yellowcard
By reporting side effects you can help provide more information
on the safety of this medicine.

5. How to store Co-tenidone Tablets
Keep out of the sight and reach of children.
Do not store above 25°C. Store in the original package in order
to protect the tablets from light and moisture.
Do not use your medicine after the expiry date shown on the
carton.
If your doctor tells you to stop taking the tablets, please take
any unused medicine back to your pharmacist to be destroyed.

6. Further information
Ingredients
Co-tenidone 50/12.5 mg Tablets contain 50 mg of atenolol and
12.5 mg of chlortalidone as the active ingredients.
Co-tenidone 100/25 mg Tablets contain 100 mg of atenolol
and 25 mg of chlortalidone as the active ingredients.
The tablets also contain magnesium carbonate (heavy),
maize starch, sodium laurilsulfate, gelatin, magnesium
stearate, hypromellose, titanium dioxide (E171),
ethylcellulose and diethyl phthalate.
What the medicine looks like
The 50/12.5 mg tablets are round, white, film-coated tablets
and the 100/25mg tablets are round, white, film-coated tablets
with a break-line.
They are supplied to your pharmacist in packs containing 28,
56, 84, 112, 140, 168, 196, 224, 252 or 280 tablets.
Not all pack sizes may be available.
MA Holder:
Special Concept Development (UK) Ltd,
Units 1-7 Colonial Way, Watford, Hertfordshire, WD24 4YR
Manufacturer: KLEVA S.A. Parnithos Ave. 189, Acharnai Attiki,
13675, Greece
Product licence numbers: PL 36722/0005 & PL 36722/0006
Date of revision: January 2015.
If you would like this leaflet in a different format, please
contact the licence holder at the above address.

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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