CO-FLUAMPICIL 250MG/250MG HARD CAPSULES
Active substance(s): AMPICILLIN TRIHYDRATE / FLUCLOXACILLIN SODIUM
Magnapen Hard Capsules
Co-fluampicil: 250mg Ampicilin/250mg Flucloxacillin
Read all of this leaflet carefully before you start using this medicine.
Keep this leaflet. You may need to read it again.
If you have further questions, please ask your doctor or nurse.
This medicine has been prescribed for you personally and you should not pass it on to others. It
may harm them, even if their symptoms are the same as yours.
The name of your medicine is Magnapen 250mg/250mg Hard Capsules. In the rest of this leaflet it is
called Magnapen Capsules.
In this leaflet:
1. What Magnapen is and what it is used for
2. Before you take Magnapen Capsules
3. How to take Magnapen Capsules
4. Possible side effects
5. How to store Magnapen Capsules
6. Further information
What Magnapen is and what it is used for
Magnapen Capsules contains two active ingredients, ampicillin and flucloxacillin which together are
known as co-fluampicil. Magnapen Capsules are an antibiotic medicine. They belong to the penicillin
group of antibiotics and work by killing bacteria that cause infections.
Magnapen Capsules are used to treat a wide range of infections caused by bacteria. These infections
may affect the chest, ear, nose, throat, skin and soft tissues.
In hospital this medicine may also be used to prevent and treat infections:
which occur after surgery
in patients receiving treatment which affects the immune system of the blood (septicaemia)
associated with difficulties in childbirth (septic abortion (abortion complicated by fever, often
leading to sepsis) and puerperal fever (an infection of the membrane of the uterus following
childbirth or abortion)).
Before you take Magnapen Capsules
Do not take Magnapen Capsules if you:
know that you are allergic to penicillin, cephalosporins, any other antibiotic or any of the
ingredients contained in Magnapen Capsules (see ‘What Magnapen Capsules contain’ in
have ever had a skin rash or swelling of the face or neck when taking an antibiotic
have ever had a serious complaint, such as liver problems, when taking an antibiotic.
If any of the above statements apply to you, you should not be given Magnapen Capsules.
Speak to your doctor before taking Magnapen Capsules if you:
are being treated for kidney or liver problems
have glandular fever
are having blood tests because your medicine sometimes causes short-term changes in blood cell
Additional monitoring of kidney and liver function is recommended for patients on prolonged
treatment e.g. osteomyelitis (bone infection) or endocarditis (infection of the muscle around the heart).
If any of the above apply your doctor may decide to change the dose of Magnapen Capsules or
prescribe a different medicine.
Taking other medicines
Taking another medicine while you are taking Magnapen Capsules can affect how it or the other
medicine works. Please inform your doctor or pharmacist if you are taking or have recently taken any
other medicines, even those you may have brought yourself without a prescription.
Tell your doctor if you are using the following medicines (or any other medicines):
a contraceptive pill as you will need to take extra precautions such as use of a condom
probenecid and allopurinol, used in the treatment of gout
or if you are being treated with any other antibiotic
If you are required to have a urine test, please inform your doctor you are taking Magnapen. False
positive results can occur with certain tests for sugar in the urine (e.g. the Fehling’s test) whilst taking
If you have any doubts about whether you should take this medicine then discuss matters with your
doctor before taking it.
Pregnancy and breast-feeding
You should let your doctor know if you are pregnant, think you might be pregnant or are breastfeeding before taking this medicine. Your doctor will decide if this medicine is suitable for you.
Important information about the sodium content of Magnapen Capsules
This medicinal product contains 13.0mg of sodium per capsule. This medicinal product contains less
than 1mmol sodium (23mg) per dose, i.e. essentially ‘sodium free’.
How to take Magnapen Capsules
Always take Magnapen Capsules exactly as your doctor has told you. You should check with
your doctor or pharmacist if you are not sure.
The dose of Magnapen your doctor prescribes and the length of time for which you will have
to take it, will depend on your infection.
The usual dose of Magnapen Capsules for the elderly, adults and children over 10 years of
age is one capsule four times a day. If your infection is severe, your doctor may double this dose
to two capsules four times a day.
For children under 10 years of age Magnapen Syrup should be used.
Try to take your capsules as part of your daily routine and space the doses as evenly as possible
through the day- for example before meal times and at bedtime. You do not need to take a dose in
the middle of the night unless your doctor has told you to do so.
Magnapen Capsules should be swallowed whole with a glass of water half an hour to one hour
before food. If this medicine is taken with food it may not work as well as it should.
If you take more Magnapen Capsules than you should
If you take too much Magnapen Capsules contact your doctor or hospital casualty department
immediately. Take this leaflet and any remaining capsules with you. Symptoms of an overdose include
feeling sick, being sick and diarrhoea.
If you miss a dose of Magnapen Capsules
If you forget to take a dose at the right time, take it as soon as you remember. Then go on as before.
But don’t take the next dose too soon. Always try to keep the doses evenly spaced and do not take two
doses within one hour or so of each other.
If you stop taking Magnapen Capsules
Keep taking your capsules until the prescribed course is finished. Do not stop just because you feel
better. If you stop too soon, the infection may start up again. If you feel unwell at the end of your
course of treatment, tell your doctor.
Possible side effects
Like many medicines, Magnapen Capsules may cause side effects in some patients, particularly when
treatment is first started, although not everybody gets them.
Stop taking Magnapen Capsules and see your doctor immediately if you:
get severe diarrhoea with bleeding or stomach pain
notice your urine becoming darker or your faeces becoming paler
notice your skin or the whites of your eyes turning yellow
notice red or purple discolorations on the skin
notice that your face is swollen and you have breathing problems
start to itch or get a rash.
notice blistering of the skin, mouth, eyes or genitals
notice increased bleeding/bruising, pale skin or weakness (due to changes in the levels of certain
develop nephritis (inflammation of the kidneys that can cause swollen ankles or high blood
develop a fever.
Frequent side effects which are usually mild include:
nausea (feeling sick)
vomiting (being sick)
Some of these reactions can be delayed for several weeks after finishing the treatment.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side
effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme
By reporting side effects you can help provide more information on the safety of this medicine.
How to store Magnapen Capsules
Keep out of the reach and sight of children
Do not take the medicine after the expiry date printed on the pack. The expiry date refers to the last
day of that month.
Do not store above 25ºC.
Store in the original container in order to protect from moisture.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to
dispose of medicines no longer required. These measures will help to protect the environment.
What Magnapen Capsules contain
Magnapen Capsules contain two active ingredients, ampicillin and flucloxacillin which together are
known as co-fluampicil. Each capsule contains 250mg ampicillin as ampicillin trihydrate and 250mg
of flucloxacillin as flucloxacillin sodium.
Your medicine also contains inactive ingredients. These are quinoline yellow (E104), patent blue V
(E131), iron oxides (E172), titanium dioxide (E171), magnesium stearate (E572) and gelatin.
Contents of the pack
Magnapen Capsules are available in two pack sizes, 28 and 100.
The most common pack of capsules you are likely to receive is 28 capsules, but this may vary
depending on the length of treatment your doctor has prescribed.
Marketing Authorisation Holder and Manufacturer
Marketing Authorisation Holder: Wockhardt Ltd, Ash Road North, Wrexham, LL13 9UF, UK
Manufacturer: Laboratorio Reig Jofre, S.A, c/Jarama, s/n. (Poligono Industrial) 45007 Toledo, Spain.
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Magnapen Hard Capsules
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This leaflet was last revised in 08/2015
Source: Medicines and Healthcare Products Regulatory Agency
Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.