Skip to Content



PDF options:  View Fullscreen   Download PDF

PDF Transcript

135 mm

135 mm

135 mm

If you are taking allopurinol (used for gout) with Coamoxiclav, it may be more likely that you will have an
allergic skin reaction.

What Co-amoxiclav Tablets contains:
- The active substances are Amoxicillin Trihydrate
and Potassium Clavulanate., Diluted
Each film-coated tablet contains 875mg amoxicillin
as amoxicillin trihydrate and 125mg of clavulanic acid
as potassium clavulanate, diluted.
- The other ingredients are:

Package leaflet: Information for the user

If you are taking probenecid (used for gout), your
doctor may decide to adjust your dose of Coamoxiclav.

Co-amoxiclav 875mg/125mg
film-coated Tablets

If medicines to help stop blood clots (such as
warfarin) are taken with Co-amoxiclav Tablets then
extra blood tests may be needed.

(Amoxicillin/clavulanic acid)
Cellulose, microcrystalline (E460)
Sodium starch glycolate, Type A
Silica, Colloidal anhydrous (E551)
Magnesium Stearate (E470b)

What Co-amoxiclav looks like and contents of the
White, capsule-shaped film-coated tablet, debossed
with 'I 07' on one side and plain on the other.
The tablets are packaged in aluminium blister strips
consisting of: 4, 5, 6, 7, 8, 10, 12, 14, 15, 16, 20, 21,
25, 30, 35, 40, 50, 100 & 500 tablets
Not all pack sizes may be marketed
Marketing Authorisation Holder and
Brown & Burk UK Ltd
5 Marryat Close
Hounslow West
This medicinal product is authorised in the
Member States of the EEA under the following
UK & IE: Co-amoxiclav 875mg/125mg Film-coated
SE: Amoxicillin/ Clavulanic acid BB 875mg/125mg
filmdragerade tabletter
This leaflet was last approved on 04.07.2017

If you forget to take a dose, take it as soon as you
remember. You should not take the next dose too
soon, but wait about 4 hours before taking the next

Ask your doctor or pharmacist for advice before
taking any medicine.

If you stop taking Co-amoxiclav Tablets
Keep taking Co-amoxiclav until the treatment is
finished, even if you feel better. You need every dose
to help fight the infection. If some bacteria survive
they can cause the infection to come back.

Co-amoxiclav can have side effects and the
symptoms may make you unfit to drive.
Don't drive or operate machinery unless you are
feeling well.

If you have any further questions on the use of this
product, ask your doctor or pharmacist.

3. How to take Co-amoxiclav Tablets

Conditions you need to look out for:

4. Possible side effects

Always take Co-amoxiclav Tablets exactly as your
doctor has told you. You should check with your
doctor or pharmacist if you are not sure.

Co-amoxiclav can make some existing conditions
worse, or cause serious side effects. These include
allergic reactions, convulsions (fits) and inflammation
of the large intestine. You must look out for certain
symptoms while you are taking Co-amoxiclav, to
reduce the risk of any problems. See 'Conditions you
need to look out for' in Section 4.

Like all medicines, this medicine can cause side
effects, although not everybody gets them.
Conditions you need to look out for

Adults and children weighing 40 kg and over

Inflammation of the large intestine (see above)
Serious skin reactions:
a widespread rash with blisters and peeling skin,
particularly around the mouth, nose, eyes and
genitals (Stevens-Johnson syndrome), and a
more severe form causing extensive peeling of
the skin (more than 30% of the body surface –
toxic epidermal necrolysis)
widespread red skin rash with small puscontaining blisters (bulloous exfoliative
a red, scaly rash with bumps under the skin and
blisters (exanthemous pustulosis).
Inflammation of the protective membrane
sorrunding the brain (aseptic meningitis)

these symptoms. Stop taking Co-amoxiclav
Inflammation of large intestine
Inflammation of the large intestine, causing watery
diarrhoea usually with blood and mucus, stomach
pain and/or fever.
Contact your doctor as soon as possible for
advice if you get these symptoms.
Very common side effects
These may affect more than 1 in 10 people
diarrhoea (in adults).

Contact a doctor immediately if you get any of
these symptoms:
inflammation of the liver (hepatitis)
jaundice, caused by increases in the blood of
bilirubin (a substance produced in the liver) which
may make your skin and whites of eyes appear
inflammation of tubes in the kidney
blood takes longer to clot
convulsions (in people taking high doses of Coamoxiclav or who have kidney problems)
black tongue which looks hairy

Common side effects
These may affect up to 1 in 10 people
thrush (candida - a yeast infection of the vagina,
mouth or skin folds)
feeling sick (nausea), especially when taking high
If affected take Co-amoxiclav before food
Diarrhoea (in children)
Uncommon side effects

Side effects that may show up in your blood or urine
severe reduction in the number of white blood cells
low number of red blood cells (haemolytic
crystals in urine.

These may affect up to 1 in 100 people
skin rash, itching
raised itchy rash (hives)

Reporting of side effects
If you get any side effects, talk to your doctor,
pharmacist or nurse. This includes any possible side
effects not listed in this leaflet. You can also report
side effects directly via the Yellow Card Scheme,
website By reporting
side effects you can help provide more information on
the safety of this medicine.

Uncommon side effects that may show up in your
blood tests:
increase in some substances (enzymes) produced
by the liver
Rare side effects
These may affect up to 1 in 1000 people
skin rash, which may blister, and looks like small
targets (central dark spots surrounded by a paler
area, with a dark ring around the edge-erythema

5. How to store Co-amoxiclav Tablets
Keep this medicine out of the sight and reach of

Allergic reactions:
Usual dose - 1 tablet two times a day
Higher dose - 1 tablet three times a day

Blood and urine tests:

skin rash
inflammation of blood vessels (vasculitis) which
may be visible as red or purple raised spots on the
skin, but can affect other parts of the body
fever, joint pain, swollen glands in the neck, armpit
or groin
swelling, sometimes of the face or mouth
(angioedema), causing difficulty in breathing

Children weighing less than 40 kg

If you are having blood tests (such as red blood cell
status tests or liver function tests) or urine tests (for
glucose), let the doctor or nurse know that you are
taking Co-amoxiclav. This is because Co-amoxiclav
can affect the results of these types of tests.

Do not take Co-amoxiclav:
if you are allergic (hypersensitive) to amoxicillin,
clavulanic acid, penicillins or any of the other
ingredients of Co-amoxiclav tablets (listed in
section 6)

If you are pregnant, you think you might be pregnant
or if you are breast-feeding, please tell your doctor or

Driving and using machines

In some cases, your doctor may investigate the type
of bacteria that is causing your infection. Depending
on the results, you may be given a different strength of
Co-amoxiclav or a different medicine.

2. What you need to know before you take Coamoxiclav Tablets


Pregnancy and breast-feeding

If you are not sure if any of the above apply to you, talk
to your doctor or pharmacist before taking these

Co-amoxiclav is used in adults and children to treat
the following infections:
middle ear and sinus infections
respiratory tract infections
urinary tract infections
skin and soft tissue infections including dental
bone and joint infections.

If you take too much Co-amoxiclav, signs might
include an upset stomach (feeling sick, being sick or
diarrhoea) or convulsions. Talk to your doctor as soon
as possible. Take the medicine carton or bottle to
show the doctor.
If you forget to take Co-amoxiclav Tablets

Talk to your doctor or pharmacist before taking this
medicine if you:
have glandular fever
are being treated for liver or kidney problems
are not passing water regularly.

Co-amoxiclav is an antibiotic and works by killing
bacteria that cause infections. It contains two different
medicines called amoxicillin and clavulanic acid.
Amoxicillin belongs to a group of medicines called
“penicillins” that can sometimes be stopped from
working (made inactive). The other active component
(clavulanic acid) stops this from happening.

If you take more Co-amoxiclav Tablets than you

This medicine contains 0.63 mmol (or 24.632 mg)
potassium per tablet. To be taken into consideration
by patients with reduced kidney function or patients
on a controlled potassium diet.

Warnings and precautions

1. What Co-amoxiclav Tablets is and what it is
used for

Swallow the tablets whole with a glass of water at
the start of a meal or slightly before.
Space the doses evenly during the day, at least 4
hours apart. Do not take 2 doses in 1 hour.
Do not take Co-amoxiclav for more than 2 weeks. If
you still feel unwell you should go back to see the

Co-amoxiclav can affect how mycophenolate mofetil
(a medicine used to prevent the rejection of
transplanted organ ) works.

Do not take Co-amoxiclav if any of the above
apply to you. If you are not sure, talk to your doctor or
pharmacist before taking Co-amoxiclav Tablets.

What is in this leaflet:
1. What Co-amoxiclav Tablet is and what it is used for
2. What you need to know before you take Coamoxiclav Tablets
3. How to take Co-amoxiclav Tablets
4. Possible side effects
5. How to store Co-amoxiclav tablets
6. Contents of the pack and other information

How to take Co-amoxiclav Tablets

Co-amoxiclav can affect how methotrexate (a
medicine used to treat cancer or rheumatic diseases)

if you have ever had a severe allergic
(hypersensitive) reaction to any other antibiotic.
This can include a skin rash or swelling of the face
or neck
if you have ever had liver problems or jaundice
(yellowing of the skin) when taking an antibiotic.

Read all of this leaflet carefully before you start
taking this medicine because it contains
important information for you
- Keep this leaflet. You may need to read it again.
- If you have any further questions, ask your doctor
or pharmacist.
- This medicine has been prescribed for you only. Do
not pass it on to others. It may harm them, even if
their signs of illness are the same as yours.
- If you get any side effects, talk to your doctor or
pharmacist. This includes any possible side effects
not listed in this leaflet. See section 4.

Film coat
Titanium dioxide (E171)
Hypromellose (E464)
Propylene glycol (E1520)
Talc (E553b)
Ethyl cellulose

250 mm

If you have kidney problems the dose might be
changed. A different strength or a different
medicine may be chosen by your doctor.
If you have liver problems you may have more
frequent blood tests to check how your liver is

prescription and herbal medicines.

6. Contents of the pack and other information

135 mm

Children aged 6 years or less should preferably be
treated with Co-Amoxiclav oral suspension or

Other medicines and Co-amoxiclav Tablets
Please tell your doctor or pharmacist if you are using
or have recently used any other medicines. This
includes medicines that can be bought without a


Do not store above 25°C.
Do not take Co-amoxiclav tablets after the expiry date
which is stated on the carton and blister strip after
EXP. The expiry date refers to the last day of that

Rare side effects that may show up in your blood
low number of cells involved in blood clotting
low number of white blood cells.

Do not take Co-amoxiclav Tablets if you notice any
visible signs of deterioration.

Other side effects

Ask your doctor or pharmacist for advice when giving
Co-amoxiclav tablets to children weighing less than
40 kg. The tablets are not suitable for children
weighing less than 25 kg.

Warning: Allergic reactions can sometimes occur

Other side effects have occurred in a very small
number of people but their exact frequency is

Patients with kidney and liver problems

Contact a doctor immediately if you get any of

Allergic reactions (see above)



If you notice any of these symptoms contact a doctor

Medicines should not be disposed of via wastewater
or household waste. Ask your pharmacist how to
dispose of medicines no longer required. These
measures will help to protect the environment.


+ Expand Transcript

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.