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CILOXAN 0.3% W/V EYE DROPS SOLUTION

Active substance(s): CIPROFLOXACIN / CIPROFLOXACIN HYDROCHLORIDE

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Ciloxan® 0.3% w/v Eye Drops Solution

Ref: 0995/211014/1/F

(ciprofloxacin hydrochloride)
Patient Information Leaflet
Read all of this leaflet carefully before you start
using this medicine.
- Keep this leaflet. You may need to read it again.
- If you have any further questions, ask your
doctor or your pharmacist.
- This medicine has been prescribed for you. Do not
pass it on to others. It may harm them, even if
their symptoms are the same as yours.
- If any of the side effects get serious, or if you
notice any side effects not listed in this leaflet,
please tell your doctor or pharmacist.
Your medicine is called Ciloxan 0.3% w/v Eye Drops
Solution but will be referred to as Ciloxan throughout
the leaflet.

In this leaflet:
1 What Ciloxan is and what it is used for
2 Before you use Ciloxan
3 How to use Ciloxan
4 Possible side effects
5 How to store Ciloxan
6 Further information

1

What Ciloxan is and what it is used for

Ciloxan belongs to a group of medicines known as
quinolone antibiotics.
It is used for the treatment of corneal ulcers and
some other bacterial infections of the eye(s).

2

Before you use Ciloxan

Do not use Ciloxan...
• If you are allergic (hypersensitive) to
ciprofloxacin or any other quinolone antibiotic
or to any of the other ingredients listed in section 6.
Ask your doctor for advice.
Take special care...
• Only use Ciloxan in your eyes.
• Only use Ciloxan in children younger than
1 year if prescribed by your doctor.
• As with any antibiotic, use of Ciloxan for
a long time may lead to other infections. If your
symptoms get worse or suddenly return tell your
doctor. You may become more susceptible to other
infections with the use of this medicine, especially
after prolonged use.
• If you notice the first signs of a skin rash or any
other allergic reaction, including hives, itching,
breathing problems stop treatment and
immediately contact your doctor. If you have a
serious allergic reaction then you may need
emergency treatment.
• If you feel pain, swelling or inflammation while or
shortly after taking this medicine, stop treatment
and contact your doctor.
• If you are elderly or if you are taking medicines
called 'corticosteroids' used to treat conditions such
as pain and inflammation, asthma or skin problems
then you have a higher risk of getting tendon
problems during treatment with Ciloxan. If you
experience any inflammation or inflammatory
condition, stop treatment and immediately consult
your doctor.

Pregnancy and breast-feeding
If you are pregnant or might get pregnant, or if you
are breast-feeding a baby, talk to your doctor
before you use Ciloxan.
Driving and using machines
If your sight is temporarily blurred or affected
in any way following use of Ciloxan you
should not drive or operate machinery until
your vision is clear again.
Using other medicines
Tell your doctor or pharmacist if you are taking or
have recently taken any other medicines, including
medicines obtained without a prescription.
If you are using more than one type of eye
medicine, the medicines must be used at least
5 minutes apart. Eye ointments should be used
last.
Important information if you wear Contact
Lenses
There is a preservative in Ciloxan (benzalkonium
chloride) that may cause eye irritation and can
discolour soft contact lenses.
Do not wear contact lenses (hard or soft) during
treatment with Ciloxan. If you do continue to wear
your lenses, you must remove them before using
Ciloxan and wait at least 15 minutes after use before
putting your lenses back in.

3

How to use Ciloxan

The usual dose
This will depend on whether you are being treated
for corneal ulcers or for some other bacterial
infection in your eye.
Corneal Ulcers
Dosing is continued during the night time.
Day 1 - 2 drops every 15 minutes for the first 6
hours and then 2 drops every 30 minutes.
Day 2 - 2 drops every hour.
Day 3 to Day 14 - 2 drops every 4 hours.
Your doctor will tell you if treatment needs to be
continued for longer than 14 days.
Other bacterial infections
1 or 2 drops 4 times a day. For severe infections the
dose for the first 2 days may be increased to 1 or 2
drops every 2 hours, while you are awake.
It is important that you continue to use Ciloxan for
the full treatment period as advised by your doctor
even if your symptoms improve. If you stop using
this medicine too early, your symptoms may
re-occur.
You should not use Ciloxan for more than 21
days, unless your doctor says otherwise.
Remove the loose collar from the cap when the
bottle is first opened.
Always use Ciloxan exactly as your doctor has told
you. You should check with your doctor or
pharmacist if you are not sure.

How to use

• Wash your hands before you
start.

• Twist off the bottle cap.
• Hold the bottle pointing

1

down, between your thumb
and fingers.

Reporting of side effects
If you get any side effects, talk to your doctor,
pharmacist or nurse. This includes any possible
side effects not listed in this leaflet. You can also
report side effects directly via the Yellow Card
Scheme at: www.mhra.gov.uk/yellowcard.
By reporting side effects you can help provide
more information on the safety of this medicine.
If you experience an allergic reaction, stop
using Ciloxan and tell your doctor .

• Tilt your head back.
• Pull down your lower eyelid

5

with a finger, until there is a
'pocket' between the eyelid and
your eye. The drop will go in here (picture 1).
• Bring the bottle tip close to the eye. Do this in front
of a mirror if it helps.
• Do not touch your eye or eyelid, surrounding
areas or other surfaces with the dropper. It could
infect the drops.
• Gently press on the base of the bottle to release
one drop at a time (picture 2).
• Do not squeeze the bottle, only a gentle press on
the bottom is needed.
• If you use drops in both eyes, repeat the steps for
your other eye. Put the bottle cap firmly back on
immediately after use.

• If a drop misses your eye, try again.
• If you forget to use Ciloxan, do not worry, just

use it when it is next due. Do not take a double
dose to make up.
• If you use more Ciloxan than you should it can
be washed out of your eye with lukewarm water.
• If this medicine is accidentally swallowed, it is
not likely to cause any serious problems, but
contact your doctor.
If you have any further questions on the use of
Ciloxan, ask your doctor or pharmacist.

4

Possible side effects

Like all medicines, CILOXAN can cause side
effects, although not everybody gets them.

• You may experience some or all of the
following effects in your eye(s) :
Common (1 to 10 users in 100): White deposits on
the eye surface (cornea), discomfort (stinging or
burning, gritty feeling in the eye, irritation), redness.
Uncommon (1 to 10 users in 1,000): Damage
to the eye surface (cornea), sensitivity to light,
blurred vision, swelling of the eye or eyelid,
pain, dry eye, itchiness, eye discharge, eyelid
crusting, eyelids scales, eyelid redness, poor
vision, watery eyes, red eyes
Rare (1 to 10 users in 10,000): Damage of the
eye, inflammation, double vision, decreased
eye sensation, tired eyes, stye.
If you notice white particles in your eyes, continue
to use CILOXAN but tell your doctor immediately.
• You may also experience effects in other areas
of your body including:
Common: Bad taste.
Uncommon: Headache, nausea.
Rare: Hypersensitivity, dizziness, ear pain,
inflammation inside the nose, nasal sinus
discharge, diarrhoea, abdominal pain, skin
inflammation, tendon disorder.

How to store Ciloxan

2

Storing your medicine
• Do not store above 25°C. Store upright.
• KEEP OUT OF THE SIGHT AND REACH OF
CHILDERN
• Do not refrigerate or freeze
• Keep the bottle tightly close
• Do not use the drops after the expiry date (marked
‘EXP’) on the bottle and the carton. The expiry
date refers to the last day of that month.
• Stop using the bottle 28 days after first opening, to
prevent infections.
• Medicines should not be disposed of via waste
water or household waste. Ask your pharmacist
how to dispose of medicines no longer required.
These measures will help protect the
environment.
• Do not pass this medicine on to others. It may
harm them even if their symptoms are the same
as yours.
6

Further Information

What Ciloxan contains.
Ciloxan is supplied as a sterile solution in a 5 ml
dropper bottle containing 0.3% w/v ciprofloxacin
(equivalent to 0.35% ciprofloxacin hydrochloride). It
also contains 0.006% w/v of benzalkonium chloride
as a preservative. Other ingredients are sodium
acetate, acetic acid, mannitol, edetate disodium and
purified water. Hydrochloric acid and/or sodium
hydroxide may also be included in very small
quantities to adjust the acidity or alkalinity of the
product to ensure comfort of the product in the eye.
What Ciloxan looks like and contents of the
pack.
Your medicine is a clear, colourless to pale yellow
solution, and is available in packs of 5ml.
Manufacturer and Licence Holder
Ciloxan is manufactured by Alcon-Couvreur N.V.,
Puurs, Belgium, and is procured from within the EU
and repackaged by the Product Licence Holder:
Lexon (UK) Limited, Unit 18, Oxleasow Road, East
Moons Moat, Redditch, Worcestershire, B98 0RE.

POM PL 15184/0995
Ciloxan is a registered trademark of Alcon Inc.
Leaflet revision date: 21/10/14

Blind or partially sighted?
Is this leaflet hard to see or read?
Phone Lexon (UK) Limited,
Tel: 01527 505414 for help.

Ref: 0995/211014/1/B

Ref: 0995/211014/2/F

Ciprofloxacin 0.3% w/v Eye Drops Solution
Patient Information Leaflet
Read all of this leaflet carefully before you start
using this medicine.
- Keep this leaflet. You may need to read it again.
- If you have any further questions, ask your
doctor or your pharmacist.
- This medicine has been prescribed for you. Do not
pass it on to others. It may harm them, even if
their symptoms are the same as yours.
- If any of the side effects get serious, or if you
notice any side effects not listed in this leaflet,
please tell your doctor or pharmacist.
Your medicine is called Ciprofloxacin 0.3% w/v Eye
Drops Solution but will be referred to as
Ciprofloxacin throughout the leaflet.

In this leaflet:
1 What Ciprofloxacin is and what it is used
for
2 Before you use Ciprofloxacin
3

How to use Ciprofloxacin

4

Possible side effects

5

How to store Ciprofloxacin

6

Further information

1

What Ciprofloxacin is and what it is
used for

Ciprofloxacin belongs to a group of medicines
known as quinolone antibiotics.
It is used for the treatment of corneal ulcers and
some other bacterial infections of the eye(s).

2

Before you use Ciprofloxacin

Do not use Ciprofloxacin...
• If you are allergic (hypersensitive) to
ciprofloxacin or any other quinolone antibiotic
or to any of the other ingredients listed in section
6.
Ask your doctor for advice.
Take special care...
• Only use Ciprofloxacin in your eyes.
• Only use Ciprofloxacin in children younger than
1 year if prescribed by your doctor.
• As with any antibiotic, use of Ciprofloxacin for a
long time may lead to other infections. If your
symptoms get worse or suddenly return tell your
doctor. You may become more susceptible to
other infections with the use of this medicine,
especially after prolonged use.
• If you notice the first signs of a skin rash or any
other allergic reaction, including hives, itching,
breathing problems stop treatment and
immediately contact your doctor. If you have a
serious allergic reaction then you may need
emergency treatment.
• If you feel pain, swelling or inflammation while or
shortly after taking this medicine, stop treatment
and contact your doctor.
• If you are elderly or if you are taking medicines
called 'corticosteroids' used to treat conditions
such as pain and inflammation, asthma or skin
problems then you have a higher risk of getting
tendon problems during treatment with
Ciprofloxacin.

If you experience any inflammation or inflammatory
condition, stop treatment and immediately consult
your doctor.
Pregnancy and breast-feeding
If you are pregnant or might get pregnant, or if
you are breast-feeding a baby, talk to your doctor
before you use Ciprofloxacin.
Driving and using machines
If your sight is temporarily blurred or affected
in any way following use of Ciprofloxacin you
should not drive or operate machinery until your
vision is clear again.
Using other medicines
Tell your doctor or pharmacist if you are taking or
have recently taken any other medicines, including
medicines obtained without a prescription.
If you are using more than one type of eye medicine,
the medicines must be used at least 5 minutes
apart. Eye ointments should be used last.
Important information if you wear Contact
Lenses
There is a preservative in Ciprofloxacin
(benzalkonium chloride) that may cause eye
irritation and can discolour soft contact lenses.
Do not wear contact lenses (hard or soft)
during treatment with Ciprofloxacin. If you do
continue to wear your lenses, you must remove
them before using Ciprofloxacinand wait at least 15
minutes after use before putting your lenses back in.

3

How to use Ciprofloxacin

The usual dose
This will depend on whether you are being treated
for corneal ulcers or for some other bacterial
infection in your eye.
Corneal Ulcers
Dosing is continued during the night time.
Day 1 - 2 drops every 15 minutes for the first 6
hours and then 2 drops every 30 minutes.
Day 2 - 2 drops every hour.
Day 3 to Day 14 - 2 drops every 4 hours.
Your doctor will tell you if treatment needs to be
continued for longer than 14 days.
Other bacterial infections
1 or 2 drops 4 times a day. For severe infections the
dose for the first 2 days may be increased to 1 or 2
drops every 2 hours, while you are awake.
It is important that you continue to use
Ciprofloxacin for the full treatment period as
advised by your doctor even if your symptoms
improve. If you stop using this medicine too early,
your symptoms may re-occur.
You should not use Ciprofloxacin for more than 21
days, unless your doctor says otherwise.
Remove the loose collar from the cap when
the bottle is first opened.
Always use Ciprofloxacin exactly as your doctor has
told you. You should check with your doctor or
pharmacist if you are not sure.

Reporting of side effects
If you get any side effects, talk to your doctor,
pharmacist or nurse. This includes any possible
side effects not listed in this leaflet. You can also
report side effects directly via the Yellow Card
Scheme at: www.mhra.gov.uk/yellowcard.
By reporting side effects you can help provide
more information on the safety of this medicine.

How to use



Wash your hands before
you start.

• Twist off the bottle cap.
• Hold the bottle pointing

down, between your thumb
and fingers.

1

If you experience an allergic reaction, stop
using Ciprofloxacin and tell your doctor.

• Tilt your head back.
• Pull down your lower

eyelid with a finger, until
2
there is a 'pocket' between
the eyelid and your eye. The drop will go in here
(picture 1).

• Bring the bottle tip close to the eye. Do this in front
of a mirror if it helps.

• Do not touch your eye or eyelid, surrounding

areas or other surfaces with the dropper. It could
infect the drops.
• Gently press on the base of the bottle to release
one drop at a time (picture 2).
• Do not squeeze the bottle, only a gentle press on
the bottom is needed.
• If you use drops in both eyes, repeat the steps for
your other eye. Put the bottle cap firmly back on
immediately after use.

• If a drop misses your eye, try again.
• If you forget to use Ciprofloxacin, do not worry,

just use it when it is next due. Do not take a
double dose to make up.
• If you use more Ciprofloxacin than you should
it can be washed out of your eye with lukewarm
water.
• If this medicine is accidentally swallowed, it is
not likely to cause any serious problems, but
contact your doctor.
If you have any further questions on the use of
Ciprofloxacin, ask your doctor or pharmacist.

4

Possible side effects

Like all medicines, Ciprofloxacin can cause side
effects, although not everybody gets them.

• You may experience some or all of the

5

How to store Ciprofloxacin

Storing your medicine
• Do not store above 25°C. Store upright.
• KEEP OUT OF THE SIGHT AND REACH OF
CHILDERN
• Do not refrigerate or freeze
• Keep the bottle tightly close
• Do not use the drops after the expiry date (marked
‘EXP’) on the bottle and the carton. The expiry
date refers to the last day of that month.
• Stop using the bottle 28 days after first opening, to
prevent infections.
• Medicines should not be disposed of via waste
water or household waste. Ask your pharmacist
how to dispose of medicines no longer required.
These measures will help protect the
environment.
• Do not pass this medicine on to others. It may
harm them even if their symptoms are the same
as yours.

6

Further Information

What Ciprofloxacin contains.
Ciprofloxacin is supplied as a sterile solution in a 5
ml dropper bottle containing 0.3% w/v ciprofloxacin
(equivalent to 0.35% ciprofloxacin hydrochloride). It
also contains 0.006% w/v of benzalkonium chloride
as a preservative. Other ingredients are sodium
acetate, acetic acid, mannitol, edetate disodium and
purified water. Hydrochloric acid and/or sodium
hydroxide may also be included in very small
quantities to adjust the acidity or alkalinity of the
product to ensure comfort of the product in the eye.
What Ciprofloxacin looks like and contents of
the pack.
Your medicine is a clear, colourless to pale yellow
solution, and is available in packs of 5ml.

following effects in your eye(s) :
Common (1 to 10 users in 100): White deposits on
the eye surface (cornea), discomfort (stinging or
burning, gritty feeling in the eye, irritation), redness.
Uncommon (1 to 10 users in 1,000): Damage
to the eye surface (cornea), sensitivity to light,
blurred vision, swelling of the eye or eyelid,
pain, dry eye, itchiness, eye discharge, eyelid
crusting, eyelids scales, eyelid redness, poor
vision, watery eyes, red eyes
Rare (1 to 10 users in 10,000): Damage of the
eye, inflammation, double vision, decreased
eye sensation, tired eyes, stye.
If you notice white particles in your eyes, continue
to use Ciprofloxacin but tell your doctor immediately.
• You may also experience effects in other areas
of your body including:
Common: Bad taste.
Uncommon: Headache, nausea.
Rare: Hypersensitivity, dizziness, ear pain,
inflammation inside the nose, nasal sinus
discharge, diarrhoea, abdominal pain, skin
inflammation, tendon disorder.

Manufacturer and Licence Holder
Ciprofloxacin is manufactured by Alcon-Couvreur
N.V., Puurs, Belgium, and is procured from within
the EU and repackaged by the Product Licence
Holder: Lexon (UK) Limited, Unit 18, Oxleasow
Road, East Moons Moat, Redditch, Worcestershire,
B98 0RE.

POM PL 15184/0995
Leaflet revision date: 21/10/14

Blind or partially sighted?
Is this leaflet hard to see or read?
Phone Lexon (UK) Limited,
Tel: 01527 505414 for help.

Ref: 0995/211014/2/B

Expand view ⇕

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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