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CEFRADINE CAPSULES 250MG

Active substance(s): CEFRADINE / CEFRADINE

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PACKAGE LEAFLET: INFORMATION FOR THE USER
Nicef Capsules 250mg and 500mg
(Cefradine)

Read all of this leaflet carefully before you start taking this medicine because it
contains important information for you.
- Keep this leaflet. You may need to read it again.
- If you have any further questions, ask your doctor or pharmacist.
- This medicine has been prescribed for you. Do not pass it on to others. It may
harm them, even if their signs of illness are the same as yours.
- If you get any side effects, talk to your doctor or pharmacist. This includes any
side effects not listed in this leaflet. See section 4.
What is in this leaflet:
1. What Nicef is and what it is used for
2. What you need to know before you take Nicef Capsules
3. How to take Nicef Capsules
4. Possible side effects
5. How to store Nicef Capsules
6. Contents of the pack and other information

1.

WHAT NICEF IS AND WHAT IT IS USED FOR

This medicine is called Nicef Capsules. Nicef Capsules contain the active substance
cefradine, which belongs to a group of medicines called cephalosporin antibiotics.
Cefradine is used to kill bacteria that cause infections in your body. These include
throat, chest and ear infections, sinus infections, infections of the skin and soft tissue
and urinary tract infections.
2.
WHAT YOU NEED TO KNOW BEFORE YOU TAKE NICEF
CAPSULES
Do not take Nicef Capsules:
 if you are allergic to cefradine or any of the ingredients contained in this medicine
(listed in section 6)
 if you are allergic to penicillin antibiotics
 if you suffer with rare hereditary problems of galactose intolerance, the Lapp
lactase deficiency or glucose-galactose malabsorption.

Warnings and precautions
Talk to your doctor or pharmacist before taking Nicef Capsules:
 if you suffer from any kidney problems, as you may require a lower dose than
normal
 if you are on kidney dialysis

 if you are diabetic. If you use chemical tests to check for sugar in urine, cefradine
may cause a false positive reaction. This does not occur with dipstick type tests, or
tests for blood sugar.
 if you have an intolerance to some sugars as this medicine contains lactose.
Other medicines and Cefradine Capsules
Tell your doctor or pharmacist if you are taking, have recently taken or might take any
other medicines. In particular tell your doctor if you are taking any of the following:
• diuretics or ‘water tablets’ e.g. furosemide
• probenecid (used to treat gout)
Pregnancy and breast-feeding
If you are pregnant or breast-feeding, think you may be pregnant or are planning to
have a baby ask your doctor or pharmacist for advice before taking this medicine.
Driving and using machines
Nicef Capsules may cause dizziness. If you experience dizziness while taking this
medicine do not drive or operate machinery.
Nicef Capsules contain lactose
Nicef Capsules contain lactose. If you have been told by your doctor that you have an
intolerance to some sugars, contact your doctor before taking this medicinal product.
Nicef Capsules 250mg contain sunset yellow FCF (E110)
Nicef Capsules 250mg contain sunset yellow FCF (E110). May cause allergic
reactions.

3.

HOW TO TAKE NICEF CAPSULES

Always take this medicine exactly as your doctor or pharmacist has told you. Check
with your doctor or pharmacist if you are not sure.
Dosage
Adults (including the elderly)
The recommended dose is 250mg or 500mg 4 times a day or 500mg – 1000mg 2
times a day.
If you are elderly your doctor will see you more often while you are taking this
medicine.
Use in children
If you are giving Cefradine Capsules to your child, your doctor will work out the right
dose depending on your child’s weight.
The recommended dose is 25mg to 50mg/kg body weight daily in divided doses.
The capsules should be swallowed whole with a glass of water and can be taken
before or after meals. However, if you find that this medicine upsets your stomach it
may help to take it with food.

If you take more Nicef Capsules than you should
If you take more capsules than you should, contact your nearest hospital casualty
department or doctor immediately. You should take this leaflet and any remaining
capsules with you to show the doctor.
If you forget to take Nicef Capsules
If you forget to take your medicine, just take your normal dose as soon as you
remember and then continue as before. Do not take a double dose to make up for a
forgotten dose.
If you stop taking Nicef Capsules
Keep taking the medicine until it is finished or your doctor tells you to stop. Do not
stop taking the medicine, even if you feel better. This will make sure that the infection
has completely cleared.
If you have any further questions on the use of this medicine, ask your doctor or
pharmacist.

4.

POSSIBLE SIDE EFFECTS

Like all medicines, this medicine can cause side effects, although not everybody gets
them.
STOP taking Cefradine Capsules and tell your doctor immediately if you
experience any of the following side effects:
▪ severe, possibly bloody diarrhoea
▪ severe peeling or blistering of the skin
▪ swelling of the face, lips and tongue, tightness of the chest and difficulty
breathing, feeling faint or itchy skin. These may be signs of an allergic reaction.
Other possible side effects:
Rare: may affect up to 1 in 1,000 people
▪ vomiting
▪ headache
▪ abdominal pain.
Not known: frequency cannot be estimated from the available data
▪ nausea (feeling sick)
▪ diarrhoea and stomach pain
▪ skin rashes
▪ confusion
▪ dizziness
▪ difficulty sleeping
▪ nervousness
▪ hyperactivity
▪ thrush
▪ heartburn tightness in the chest
▪ vaginal infection
▪ stiffness and joint pain






fever
kidney inflammation, which could cause reduced urine output, cloudy or
bloody urine, swelling and pain
temporary liver problems which can cause dark urine, pale stools, fever,
yellowing of your eyes and skin
temporary blood disorders which could cause you to have more infections than
usual and can also make your skin pale and cause weakness, breathlessness
and tiredness.

If you notice any side effects not mentioned in this leaflet, or if you suffer from any of the
side effects listed please inform your doctor or pharmacist.

Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any
possible side effects not listed in this leaflet. You can also report side effects directly
via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard
By reporting side effects you can help provide more information on the safety of this
medicine.
5.

HOW TO STORE NICEF CAPSULES

Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the carton and blister
foil. The expiry date refers to the last day of that month.
Store below 25oC. Store in the original packaging in order to protect the capsules
from light and moisture.
Do not use this medicine if you notice that the pack or any of the capsules are
damaged.
Do not throw away any medicines via wastewater or household waste. Ask your
pharmacist how to throw away medicines you no longer use. These measures will
help protect the environment.

6.

CONTENTS OF THE PACK AND OTHER INFORMATION

What Nicef Capsules contain
The active substance in Nicef Capsules is cefradine. Each capsule contains either
250mg or 500mg of cefradine. The other ingredients are sodium lauryl sulphate,
povidone, colloidal silicon dioxide, magnesium stearate and lactose monohydrate.
The 250mg capsule shells are made of gelatin and contain sunset yellow (E110), FD
& C Blue 2 (E132) and titanium dioxide (E171) as colouring agents. The 500mg
capsule shells are made of gelatin and contain FD & C Blue 2 (E132) and titanium
dioxide (E171) as colouring agents. The printing ink on the capsule shells contains
shellac, black iron oxide (E172) and propylene glycol.
What Nicef Capsules look like and the contents of the pack

Nicef Capsules 250mg are blue and orange hard gelatin capsules with ‘CEPHR 250’
printed in black ink.
Nicef Capsules 500mg are blue hard gelatin capsules with ‘CEPHR 500’ printed in
black ink.
Nicef Capsules 250mg and 500mg are available in packs containing 2, 4, 10, 14, 20,
28, 30, 50, 56, 60, 84, 100, 500 and 1000 capsules. Not all pack sizes may be
marketed. (Delete this section as appropriate.)
Marketing Authorisation Holder
Co-pharma
Unit 4, Metro Centre
Tolpits Lane
Watford
Herts
UK, WD18 9SS
Manufacturer
Almac Pharma Services Limited
Almac House
20 Seagoe Industrial Estate
Craigavon
BT63 5QD
UK
This leaflet was last revised in May 2017.

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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