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143 LEAFLET Cardura 20170508


(doxazosin mesilate)
Your medicine is known by the above names but will be referred to
as Cardura throughout the following leaflet.
Information for other strength of Cardura tablets (1mg) also may be
present in this leaflet.
Read all of this leaflet carefully before you start taking this
medicine because it contains important information for you.

Keep this leaflet. You may need to read it again.


If you have any further questions, ask your doctor or pharmacist.

Cardura is a treatment for high blood pressure, or the
symptoms caused by enlargement of the prostate gland in men.

This medicine has been prescribed for you only. Do not pass it
on to others. It may harm them, even if their signs of illness are
the same as yours.

You should take Cardura regularly to get the maximum benefit,
even if you are feeling well.

Most people do not have serious problems when taking
Cardura but side effects can occur. If you experience swelling
of the face, tongue or windpipe, see your doctor immediately. If
you get any side effects, talk to your doctor, pharmacist or
nurse. This includes any possible side effects not listed in this
leaflet. See section 4.

Taking other medicines may sometimes cause problems.
Check with your doctor or pharmacist before taking this or any
other medicines.

If you are, or are trying to become pregnant, do not take
Cardura and tell your doctor or pharmacist.

Warnings and precautions
Talk to your doctor or pharmacist before taking Cardura if:

you are pregnant or trying to become pregnant


you have liver disease


you are also taking other medicines


you have heart disease

If you are undergoing eye surgery because of cataract (cloudiness
of the lens) please inform your eye specialist before the operation
that you are using or have previously used Cardura. This is
because Cardura may cause complications during the surgery
which can be managed if your specialist is prepared in advance.
Before starting treatment with Cardura your doctor may perform
tests to rule out other conditions such as prostate cancer that may
cause the same symptoms as benign prostatic hyperplasia
(enlargement of the prostate gland).
Persistent painful erections may occur very rarely. If this happens
you should contact a doctor immediately.
When you start to take Cardura you may experience faintness or
dizziness caused by low blood pressure, when getting up from
sitting or lying down. If you feel faint or dizzy, you should sit or lie
down until you feel better and avoid situations where you might fall
or hurt yourself. Your doctor may want to measure your blood
pressure regularly at the start of therapy to reduce the possibility of
these effects happening.
Other medicines and Cardura
Tell your doctor or pharmacist if you are taking, have recently taken
or might take any other medicines.
There are some medicines that may interact with Cardura

Some patients who take alpha-blocker therapy for the treatment
of high blood pressure or prostate enlargement may experience
dizziness or light-headedness, which may be caused by low
blood pressure upon sitting or standing up quickly. Certain
patients have experienced these symptoms when taking drugs
for erectile dysfunction (impotence) with alpha-blockers. In
order to reduce the likelihood that these symptoms occur, you
should be on a regular daily dose of your alpha blocker before
you start drugs for erectile dysfunction.


Cardura may lower your blood pressure even more if you are
already taking other medicines to treat high blood pressure.

What is in this leaflet
1. What Cardura is and what it is used for
2. What you need to know before you take Cardura
3. How to take Cardura

Cardura with food and drink

4. Possible side effects

Please refer to section 3.

5. How to store Cardura

Pregnancy, breast-feeding and fertility

6. Contents of the pack and other information

The safety of using Cardura during pregnancy has not been
established. If you are pregnant or planning to have a baby, ask
your doctor or pharmacist for advice before taking this medicine.

Cardura is one of a group of medicines called alpha-blockers. It is
used to treat high blood pressure, or the symptoms caused by
enlargement of the prostate gland in men.
Cardura can be used to treat high blood pressure (hypertension), by
relaxing blood vessels so that blood passes through them more
easily. This helps to lower blood pressure.

Do not take Cardura if you are breast-feeding.
Driving and using machines
Take care if you drive or operate machinery. Your tablets may affect
your ability to drive or operate machinery safely, particularly when
you first start to take them. They may make you feel weak or dizzy.
If you are affected, do not drive or operate machinery and contact
your doctor immediately.

In patients with an enlarged prostate gland, Cardura is taken to
treat poor and/or frequent passing of urine. This is common in
patients with an enlarged prostate gland. Cardura works by relaxing
muscle around the bladder exit and prostate gland so urine is
passed more easily.

Cardura contains lactose



Do not take Cardura

Always take this medicine exactly as described in this leaflet or as
your doctor has told you. Check with your doctor, pharmacist or
nurse if you are not sure.


If you are allergic to doxazosin, other types of quinazolines
(such as prazosin or terazosin), or any of the other ingredients
of this medicine (listed in section 6). This may have been
itching, reddening of the skin or difficulty in breathing.


The recommended dose of Cardura is one tablet taken once a


If you are taking Cardura for the first time the normal dose is
1mg daily. Your doctor may increase this after a couple of
weeks to the usual dose of 2mg or 4mg daily. In some
circumstances this may be increased to a maximum of 8mg
daily if you are being treated for prostate enlargement, or to a
maximum of 16mg if you are being treated for high blood


Cardura may be taken in the morning or the evening.


If you have an enlarged prostate gland with one of the following:
any kind of congestion or blockage in your urinary tract, a
longstanding infection of the urinary tract or you have bladder

It is best to take your tablets at about the same time each day
with a drink of water.


Cardura can be taken with or without food.


If you have overflow incontinence (you do not feel the urge to
urinate), or anuria (your body is not producing any urine) with or
without kidney problems.

Take your tablet as your doctor told you or by following the days
and arrows on the blister foil.


It is important to keep taking your tablets. They help to control
your blood pressure.


Do not change the dose or stop taking the tablets without first
checking with your doctor.


Do not wait until your tablets are finished before seeing your


If you are breast-feeding.


If you are under 18 years of age.


If you have an enlarged prostate gland (benign prostatic
hyperplasia) and have low blood pressure.


If you have a history of a condition known as ‘orthostatic
hypotension’ which is a form of low blood pressure that causes
you to feel dizzy or light-headed when you stand up from sitting
or lying down.



Cardura contains lactose. If you have been told by your doctor that
you have an intolerance to some sugars contact your doctor before
taking this medicinal product.

Use in children

The safety and efficacy of Cardura in children have not been

Liver enzyme increases which may have an effect on some
medical tests


If you take more Cardura than you should

Rare: may affect up to 1 in 1,000 people

Too many tablets at once may make you unwell. If several tablets
are taken it may be dangerous. Tell your doctor immediately or go
to your nearest hospital casualty department.

Increased number of times of passing urine

Muscle cramps, muscle weakness

If you forget to take Cardura

Very Rare: may affect up to 1 in 10,000 people

Faintness or dizziness caused by low blood pressure when
getting up from a sitting or lying position

Hepatitis (liver inflammation) or bile disorder

Hives, hair loss, red or purple patches on the skin, bleeding
under the skin

Tingling or numbness of the hands and feet

Tiredness, generally feeling unwell

STOP taking Cardura and call an ambulance immediately if you
experience any of the following:

Aggravated wheezing

Blurred vision

Heart attack

Hot flushes

Weakness of arms, legs or problems speaking which may be
symptoms of a stroke

Disorder in passing urine, needing to pass urine at night,
increased volume of urine passed

Swelling of the face, tongue or throat which may be the result of
an allergic reaction to this medicine

Discomfort or enlargement of the breasts in men

Do not worry. If you forget to take a tablet, leave that dose out
completely. Then go on as before. Do not take a double dose to
make up for a forgotten tablet.
Like all medicines, this medicine can cause side effects although
not everybody gets them.

Tell your doctor immediately if you experience any of the following
symptoms after taking Cardura:

Shortness of breath, difficulty breathing (common: may affect up
to 1 in 10 people)

Increased or decreased heartbeat (common: may affect up to 1
in 10 people)

Feeling your heartbeat (palpitations) (common: may affect up to
1 in 10 people)

Chest pain, angina (uncommon: may affect up to 1 in 100

Irregular heartbeat (very rare: may affect up to 1 in 10,000

Yellowing of the skin or the eyes (jaundice) (very rare: may
affect up to 1 in 10,000 people)

Low numbers of white blood cells or blood platelets, which may
result in bruising or easy bleeding (very rare: may affect up to 1
in 10,000 people)

Persistent painful erection of the penis. Seek urgent medical
advice (very rare: may affect up to 1 in 10,000 people)

The following events have been reported in patients being treated
with Cardura. If any of these side effects get serious, or if you notice
any side effects not listed in this leaflet, please tell your doctor.

Not known: frequency cannot be estimated from the available

Little or no semen ejaculated at sexual climax, cloudy urine
following sexual climax

Eye problems may occur during eye surgery for cataract
(cloudiness of the lens of the eye). See section “Warnings and

Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This
includes any possible side effects not listed in this leaflet. You can
also report side effects directly via the relevant national reporting
system detailed below:
Yellow Card Scheme at:
By reporting side effects you can help provide more information on
the safety of this medicine.


Do not store your tablets above 30°C.

Do not use Cardura after the expiry date which is stated on the
carton and blister strip. The expiry date refers to the last day of
that month.

Tablets should not be thrown in your bin or put down the drain.
If they are out of date, or no longer suitable for you, return them
to your pharmacist.

Common: may affect up to 1 in 10 people

Dizziness, feeling of spinning or rotation of surroundings
(vertigo), headache

Low blood pressure

Swelling of feet, ankles or fingers


Chest cold, coughing, respiratory tract (nose, throat, lungs)

What Cardura contains

Nasal stuffiness, sneezing and/or runny nose caused by
inflammation of the lining of the nose (rhinitis)

Stomach/abdominal pains, feeling/being sick

Urinary tract infection, urinary incontinence (inability to control
passing urine), inflammation of bladder (cystitis)

What Cardura looks like and contents of the pack

Sleepiness, general weakness

Indigestion, heartburn, dry mouth

Cardura are white, capsule-shaped and marked ‘Pfizer’ on one side
and ‘CN 2’ with a breakline on the other.


Back pain, painful muscles

Flu-like symptoms

Cardura contains 2mg of doxazosin (as mesilate) as the active

The other ingredients are: lactose, microcrystalline cellulose,
magnesium stearate, sodium starch glycollate and sodium
lauryl sulphate.

Cardura are available in blister packs of 30 tablets.
Product Licence holder

Uncommon: may affect up to 1 in 100 people

Procured from within the EU and repackaged by the Parallel Import
Product Licence holder: Chemilines Ltd, Chemilines House,
Alperton Lane, Wembley, HA0 1DX.

Constipation, wind, inflammation of the stomach and intestines
(gastroenteritis) which can cause diarrhoea and vomiting


Pain or discomfort on passing urine, increased frequency in
passing urine, blood in urine

Inflammation of the joints (gout), painful joints, general pain

Leaflet revision date: 08 May 2017

Swelling of the face

Sleeplessness, agitation, anxiety, depression or nervousness

Reduced or altered sense of touch or sensation of the hands
and feet

Increased appetite or loss of appetite, weight gain

Nose bleeds

Skin rash

Ringing or noise in the ears, tremor

Blind or partially sighted? Is
this leaflet hard to see or read?
Call 02087997607 to obtain the
leaflet in large print, tape, CD
or Braille.

Failure/ inability to achieve penile erection

Cardura is a registered trade mark of Pfizer Ltd, UK.

This product is manufactured by R-Pharm Germany GmbH,
Heinrich Mack Strasse 35, D-89257 Illertissen, Germany.

PL: 08747/0143

143 LEAFLET Cardura 20170508

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.