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Active substance(s): FELODIPINE

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567_FR00271_V5_CARDIOPLEN_567_FR00271_V5 23/06/15 15:19 Page1


Cardioplen® XL 2.5 mg, 5 mg & 10 mg
Prolonged Release Tablets
Read all of this leaflet carefully before you start taking this medicine because
it contains important information for you.
- Keep this leaflet. You may need to read it again.
- If you have any further questions, ask your doctor or pharmacist.
- This medicine has been prescribed for you only. Do not pass it on to others. It
may harm them, even if their signs of illness are the same as yours.
- If you get any side effects talk to your doctor or pharmacist. This includes any
possible side effects not listed in this leafet. See section 4.

What is in this leaflet:
1. What Cardioplen is and what it is used for
2. What you need to know before you take Cardioplen
3. How to take Cardioplen
4. Possible side effects
5. How to store Cardioplen
6. Contents of the pack and other information
1. What Cardioplen is and what it is used for
Cardioplen XL Prolonged Release Tablets contain felodipine which belongs to a group of
medicines called calcium-channel blockers that act on the cardiovascular system (the
heart and blood vessels). Cardioplen has been prescribed by your doctor to treat your
high blood pressure or to reduce the frequency of your anginal attacks. They are called
prolonged release tablets because they are manufactured in a way that allows the
felodipine to be released and slowly absorbed by your body over a period of several
In high blood pressure, felodipine works by widening the blood vessels. This creates less
resistance to the blood flow, and results in lower blood pressure, which in turn reduces
the strain on your heart.
In angina, felodipine works by opening up the arteries supplying the heart muscle and
this allows more blood and oxygen to reach the muscle, decreasing the chances of
angina (chest pains) occurring when extra strain is placed upon the heart.

2. What you need to know before you take Cardioplen
Do not take Cardioplen:
‡ if you are allergic to felodipine, other calcium-channel blockers (e.g. amlodipine,
nisoldipine or nifedipine) or any of the other ingredients in Cardioplen
‡ if you are pregnant, likely to become pregnant or are breast-feeding
‡ if you have been told that you have a narrowing of the aortic valve in your heart
‡ if you have experienced a collapse which was caused by a heart problem
‡ if the severity or frequency of your angina has rapidly worsened over a matter of
hours or days
‡ if you have had a heart attack during the last month or have other severe heart
Take special care with Cardioplen and always tell your doctor if:
‡ you suffer from low blood pressure with abnormal rapid heartbeats
‡ you have a poorly functioning left ventricle of your heart
‡ you suffer from liver problems.
Taking other medicines
Before starting treatment, please tell your doctor or pharmacist if you are taking or have
recently taken any other medicines, including medicines obtained without a prescription.
If you have to go to a doctor, dentist or hospital for any reason, tell them that you are
taking Cardioplen. This is especially important if you are likely to have an anaesthetic or
an operation.

particular, tell your doctor if you are taking:
cimetidine, to treat stomach ulcers
the antibiotic erythromycin, to treat bacterial infections
Medicines to treat fungal infections, including itraconazole and Ketoconazole
ritonavir, to treat HIV infection
tacrolimus, used after kidney or liver transplants
Any other medicines to lower blood pressure
phenytoin, carbamazepine or phenobarbital, to treat seizures or epilepsy. If you are
already taking any of these medicines, your doctor may prescribe higher than normal
doses of Cardioplen for you to take.

Taking Cardioplen with food and drink
Do not drink grapefruit juice at the same time or soon after taking Cardioplen
because grapefruit juice can increase the blood levels of felodipine and affect the way it
works. It is best to take your tablets on an empty stomach or after a light meal.
Pregnancy, breast-feeding and fertility
Do not take Cardioplen if you are pregnant, trying to become pregnant or are breastfeeding.
Driving and using machines:
If you feel dizzy or extremely tired after taking Cardioplen, then do not drive or
operate machinery.
Important information about some of the ingredients of Cardioplen
Cardioplen contains lactose monohydrate. If you have been told by your doctor that you
have an intolerance to some sugars, contact your doctor before taking this medicinal

Please read the back of this leaflet →

567_FR00271_V5_CARDIOPLEN_567_FR00271_V5 23/06/15 15:19 Page2

3. How to take Cardioplen
Always take Cardioplen exactly as your doctor has told you to. You should check with
your doctor or pharmacist if you are not sure.
The label on the carton will tell you how many tablets you should take and when. It is
very important that you take your tablets regularly. Do not stop treatment even if you
feel better unless told to do so by your doctor.
Cardioplen is formulated so that you only have to take your tablets once a day. It is
important that you take your tablets at the same time each day, preferably in the
morning on an empty stomach or after a light meal. Your tablets must be swallowed
whole with a glass of water and not with grapefruit juice. Do not break or chew your
High blood pressure
Adults and the elderly: the usual dose is 5 mg once a day. Your doctor may decide
to increase your dose to a maximum of 20 mg of Cardioplen once a day or prescribe
another medicine to treat your high blood pressure for you to also take whilst you are
taking Cardioplen.
If you are elderly, your doctor may prescribe a lower starting dose of 2.5 mg for you to
take once a day.
Adults: the usual dose is 5 mg once a day. Your doctor may decide to increase your
dose to a maximum of 10 mg of Cardioplen once a day.
Do not stop taking your medicine until your doctor tells you.
Children must not take this medicine.
If you take more Cardioplen than you should
If you accidentally take more Cardioplen than you should, contact your nearest casualty
department or tell your doctor or pharmacist immediately. Remember to take the pack
and any remaining tablets with you.
If you forget to take Cardioplen
Do not worry. Simply leave out that dose completely and then take your next dose at the
right time. Do not take a double dose to make up for a missed dose.
If you have any further questions on the use of this product, ask your doctor or

4. Possible side effects
Like all medicines, Cardioplen can cause side effects, although not everyone gets them.
Allergic reactions, although serious, have been reported in isolated cases. If you
experience any of the following, contact your doctor or casualty department immediately:
• swelling of the face and throat
• itchy red rash
If you experience chest pains when you first start taking Cardioplen, contact your
doctor immediately.
The following side effects do not usually last long and are most likely to occur when you
first start to take your medicine or if your dose has been increased. If they continue or if
you are worried, contact your doctor or pharmacist immediately:
• headache
• palpitations
Also, some people experience:

• dizziness and tiredness
• reddening of the skin

swelling of the ankles
swollen gums
skin inflammation, rash or itching
skin sensitive to light
pain in joints and muscle aches
pins and needles in your toes and

feeling sick
abnormal liver blood test
rapid heartbeat
swelling of the hands or feet caused by
fluid build up under the skin
• worsening of swollen gums. This can be
prevented by careful dental hygiene.

If any of the side effects get serious, or if you notice any side effects not listed
in this leaflet, please tell your doctor or pharmacist.
Reporting of side effects
If you get any side effects talk to your doctor, pharmacist, or nurse. This includes any
possible side effects not listed in this leaflet. You can also report side effects directly via
the YellowCard Scheme at By reporting side effects you
can help provide more information on the safety of this medicine.

5. How to store Cardioplen
• Keep this medicine out of the sight and reach of children.
• Do not store above 25°C. Store in the original packaging.
• Do not use Cardioplen after the expiry date which is stated on the blister and carton.
The expiry date refers to the last day of that month.
• Medicines should not be disposed of via wastewater or household waste. Ask your
pharmacist how to dispose of medicines no longer required. These measures will help
protect the environment.

6. Contents of the pack and other information
What Cardioplen contains:
‡ The active substance in your tablets is felodipine. Each tablet contains 2.5 mg, 5 mg or 10 mg
of felodipine.
‡ The other ingredients are lactose monohydrate, cellulose microcrystalline, talc,
hypromellose, povidone, propyl gallate, silica colloidal anhydrous, magnesium
stearate, ferric oxide yellow (E172), ferric oxide red (E172), titanium dioxide (E171)
and propylene glycol.
What Cardioplen looks like and the contents of the pack:
Cardioplen XL Tablets are round and biconvex in shape and are available in blister packs of 28
tablets. Each strength can be identified by its colour and marking.
2.5 mg tablets are yellow and marked with “2.5”
5 mg tablets are light pink and marked with “5”
10 mg tablets are reddish brown and marked with “10”
Marketing Authorisation Holder and Manufacturer:
The Marketing Authorisation holder and manufacturer is Chiesi Limited, 333 Styal Road, Manchester,
M22 5LG, UK.

Is this leaflet hard to see or read? Phone 0161 488 5555 for help.
This leaflet was last approved in 07/2015

FR00271.V5 / CP0025/5

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.