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Active substance(s): LEUCOVORIN CALCIUM

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Calcium Folinate 15 mg Tablets

Read Direction

Read all of this leaflet carefully before you start taking this medicine.
• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor or pharmacist.
• This medicine has been prescribed for you. Do not pass it on to others. It may harm
them, even if their symptoms are the same as yours.
• If any of the side effects gets serious, or if you notice any side effects not listed in this
leaflet, please tell your doctor or pharmacist.
In this leaflet:
1. What Calcium Folinate is and what it is used for
2. Before you take Calcium Folinate Tablets
3. How to take Calcium Folinate Tablets
4. Possible side effects
5. How to store Calcium Folinate Tablets
6. Further information

Calcium folinate is one of the B group of vitamins.
Calcium folinate is used to reduce the harmful effects of certain types of medicines called
folic acid antagonists, e.g. methotrexate.
Calcium folinate may also be used to treat some types of anaemia (megaloblastic anaemias)
when they occur during pregnancy and infancy or they are caused by liver disease,
inadequate food intake or poor food absorption.

Do not take Calcium Folinate Tablets

• if you have shown signs of hypersensitivity (severe allergy) to calcium folinate or any of
the other ingredients (see section 6) in the past
• if you have a type of anaemia caused by too little vitamin B12
• if you have one of the following hereditary sugar intolerances:
• galactose intolerance
• Lapp lactase deficiency
• glucose-galactose malabsorption
Tell your doctor if any of the above applies to you before this medicine is used.

Taking/using other medicines
Special care is needed if you are taking/using other medicines as some could interact with
calcium folinate, for example:
• taking the anti-cancer medicines capecitabine, fluorouracil, or medicines of the same
family (fluoropyrimidines), and calcium folinate together may be linked to seizures (fits)
and fainting
• the effectiveness of phenobarbitone, phenytoin and primidone (used to treat epilepsy)
may be reduced by calcium folinate. Your doctor may check blood levels of these
medicines and change your dose to prevent increased seizures (fits)
Please tell your doctor if you are taking or have recently taken any other medicines,
including medicines obtained without a prescription.

Pregnancy and breast-feeding
Tell your doctor if you are pregnant, trying to become pregnant or breast-feeding.
Your doctor will advise you whether you should take this medicine whilst pregnant or
Ask your doctor or pharmacist for advice before taking any medicine.

Important information about one of the ingredients of Calcium Folinate Tablets
These tablets contain lactose. If you have been told by your doctor that you have an
intolerance to some sugars, contact your doctor before taking this medicine.


Reduction of harmful effects of folic acid antagonists
If used to reduce the harmful effects of folic acid antagonist medicines such as methotrexate,
treatment with calcium folinate is usually started 24 hours after the folic acid antagonist has
been given. The dose is usually one 15 mg tablet every 6 hours for 2 days. You will probably
also be asked to take another medicine to make your urine alkaline at the same time as this
will also help reduce the toxic effects of the folic acid antagonist.
Where high doses of folic acid antagonists have been used, or where there has been an
overdose of such medicines, calcium folinate treatment is usually given by injection.
Megaloblastic anaemia
In the treatment of megaloblastic anaemia the dose is one 15 mg tablet daily.

If you take more Calcium Folinate Tablets than you should
Tell your doctor or pharmacist immediately.


Read Direction

Always take Calcium Folinate exactly as your doctor has instructed you. You should always
check with your doctor or pharmacist if you are unsure.
The tablets should be swallowed whole with a drink of water.
Your doctor may also ask you to drink more than usual.

If you forget to take Calcium Folinate Tablets
If you forget to take your tablet, take it as soon as you can, but do not take a double dose to
make up for forgotten tablet.

Like all medicines, calcium folinate can cause side effects, although not everybody gets

Read Direction

If the following happens, tell your doctor immediately:

• severe allergic reaction - you may experience a sudden itchy rash (hives), swelling of the
hands, feet, ankles, face, lips, mouth or throat (which may cause difficulty in swallowing or
breathing), and you may feel you are going to faint. This is a serious side effect. You may
need urgent medical attention.
If calcium folinate is given with another drug called fluorouracil (to treat cancer) the following
side effects have been reported:
• decreased white blood cell count or low platelets in the blood. Symptoms may include
bruising, nose bleeds or rash. Your doctor will take regular blood tests to check these.
• sore and inflamed mouth (stomatitis) and/or diarrhoea.
If you have received calcium folinate by injection, prior to receiving the tablets, you can also
get a high temperature.

Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any
possible side effects not listed in this leaflet.
You can also report side effects directly via:

United Kingdom
Yellow Card Scheme
By reporting side effects you can help provide more information on the safety of this

Keep out of the reach and sight of children

This medicine must not be used after the expiry date which is stated on the tablet bottle and
carton after ‘EXP’. Where only a month and year is stated, the expiry date refers to the last
day of that month.

Do not store above 25°C.
Keep tablet bottle in the outer carton.

Medicines should not be disposed of via wastewater or household waste. Ask your
pharmacist how to dispose of medicines no longer required. These measures will help to
protect the environment.

What Calcium Folinate Tablets contain
The active substance is folinic acid. Each tablet contains 15 milligrams (mg) of folinic acid in
the form of calcium folinate.
The other ingredients are microcrystalline cellulose, magnesium stearate and lactose.

What Calcium Folinate Tablets look like and contents of the pack
The tablets are round and light yellow in colour. They are scored and marked “CF” on one
It is supplied in a screw cap, plastic bottle containing 10 tablets.

Marketing Authorisation Holder and Manufacturer
Hospira UK Limited, Horizon, Honey Lane, Hurley, Maidenhead, SL6 6RJ UK
This leaflet was last updated in July 2016.

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.