Skip to Content



View full screen / Print PDF » Download PDF ⇩
Pregnancy and breast feeding
Please let the doctor know if you are pregnant, think
you might be pregnant, are planning to become
pregnant or are breast-feeding. Bisoprolol and
Aspirin capsules are not recommended during
pregnancy unless absolutely necessary, as the
possible risks to the baby are not known. Your
doctor will be able to advise you.
It is unknown if bisoprolol is excreted in the breast
milk, however, acetylsalicylic acid may be present
in breast milk. Breast-feeding during the use of this
medicinal product is therefore not recommended.
Ask your doctor or pharmacist for advice before
taking any medicine.

Driving and using machines
Bisoprolol and Aspirin capsule should not usually
affect your ability to drive or use machines. If they
make you feel tired or dizzy wait until the symptoms
have worn off before driving or using machines.

3. How to take Bisoprolol and
Aspirin capsules
Bisoprolol and Aspirin capsules should be
swallowed whole with water.

The normal dose for adults is one daily taken at
about the same time each day. Your doctor will
decide on the most suitable dose for you.
Bisoprolol and Aspirin capsules are not suitable for
Older patients
In general an adjustment of the dose is not needed.
It is recommended to start with the lowest possible
Patients with a severely reduced kidney & liver
Patients should not take this product if they suffer
from severe kidney or liver disease. For patients
with mild or moderate kidney or liver function,
special care should be taken.
Treatment with bisoprolol is usually long-term. If
you have to stop treatment entirely, your doctor will
usually advise you to reduce the dose gradually, as
otherwise your condition may become worse.

If you take more Bisoprolol and Aspirin
capsules than you should
If you have accidentally taken more than the
prescribed dose, tell your doctor/pharmacist
immediately. Take any remaining tablets or this
leaflet with you so the medical staff know exactly
what you have taken. The likely signs of an
overdose are a sudden drop in pulse rate and/or
blood pressure which may make you feel dizzy,
light-headed, confused, sick or even be sick, cause
buzzing in the ears and breathlessness. Other
symptoms could include a feeling of spinning
(vertigo), headache, ringing in the ears, confusion,
nausea, vomiting and abdominal pain. A large
overdose could cause breathing more quickly
than normal (hyperventilation), difficulty breathing,
heat stroke, sweating, restlessness, fits, seeing
things, low blood sugar and eventually loss of
consciousness or coma. Patients with heart failure
may be more sensitive to these effects.

Common (affects less than 1 person in 10) :
• stomach pain
• feeling of coldness or numbness in hands or feet
• nausea (feeling sick), vomiting (being sick)
• diarrhoea, or constipation
• increased risk of bleeding
• tiredness, dizziness, headache (these side
effects occur especially at the beginning of the
treatment and are generally mild in nature and
often disappear within 1-2 weeks)

Uncommon (affects less than 1 person in 100) :
• slow heart beat
• low blood pressure
• feeling weak
• irregular heart beat; worsening of existing heart
• stomach bleeding, stomach ulcers and
perforation, brain haemorrhage
• breathing problems in patients with asthma or
chronic lung disease
• sleep disturbances
• depression
• Light-headedness
• muscle weakness, muscle cramps.
Rare (affects less than 1 person in 1,000) :
• increase in liver enzymes
• inflammation of the liver (hepatitis), causing
abdominal pain, loss of appetite and sometimes
jaundice with yellowing of the whites of the eyes
and skin and dark urine
• changes in blood test results (e.g increase
in a type of fat found in the blood (triglycerides)
increased chemicals from the liver)
• nightmares, hallucinations
• hearing problems
• allergic runny nose
• reduced tear flow (important if you use contact
• reduced sexual potency
• fainting
• nose bleeds, bleeding from the gums, increased
menstrual bleeding
• Ringing in the ears (tinnitus), headaches,
dizziness: these signs usually reflect an
overdose of acetylsalicylic acid
Very rare (affects less than 1 person in 10,000) :
• Anaphylactic shock or worsening symptoms of
food allergy.
• severe skin reactions (e.g. erythema
exsudativum multiforme)
• cause or worsen psoriasis or a skin rash similar
to psoriasis
• irritation and redness of the eye (conjunctivitis)
• hair loss
• low blood sugar
• liver and kidney disorders
• high levels of uric acid in your blood
Please tell your doctor as soon as possible if any of
these have occurred.
Reporting of side effects
If any of the side effects gets serious, or if you
notice any side effects not listed in this leaflet,
please tell your doctor or pharmacist.
You can also report side effects directly via
the Yellow Card Scheme at
yellowcard. By repoting side effects, you can
help provide more information on the safety of
this medicine.

If you miss a dose of Bisoprolol and
Aspirin capsules

5. How to store Bisoprolol and
Aspirin capsules

If you forget a capsule, take it if you remember
within 12 hours. If more than 12 hours have passed
wait until your next dose. Do not take a double dose
to catch up.

Keep out of the reach and sight of children.
Do not store above 25°C. Do not use Bisoprolol
and Aspirin capsules after the expiry date which
is stated on the carton and blister after EXP. The
expiry date refers to the last day of that month.

If you have any further questions on the use of this
product ask your doctor or pharmacist.

If you stop taking Bisoprolol and
Aspirin capsules
Treatment with Bisoprolol acetylsalicylic acid
capsules must not be stopped abruptly as your
condition may get worse, or your blood pressure
may start to rise again. Instead, the capsules must
be reduced gradually over one or two weeks as
advised by your doctor. If you have any further
questions on the use of this product, ask your
doctor or pharmacist.

4. Possible side effects
Like all medicines Bisoprolol and Aspirin capsules
can sometimes cause side-effects, although not
everybody gets them.
All medicines can cause allergic reactions
although serious allergic reactions are very
rare. If you notice any of the following serious
side effects, stop taking Bisoprolol and Aspirin
capsules and contact a doctor immediately:

worsening of heart failure causing increased
breathlessness and / or retention of fluid
worsening of symptoms of blockage of the
main blood vessels to the legs, especially at
the start of treatment
unusal bleeding, such as coughing up
blood, blood in your vomit or urine, or black
any sudden wheeziness, difficulty in
breathing, swelling of the eyelids, face or
lips, swelling of limbs (oedema)
rash or itching (especially affecting your
whole body)

The following side-effects have also been reported:
Very Common (affects more than 1 person in 10):
• pain or discomfort in your stomach or lower
chest after eating
• nausea

Medicines should not be disposed of via wastewater
or household waste. Ask your pharmacist how to
dispose of medicines no longer required. These
measures will help to protect the environment.

6. Further information
The active substances are bisoprolol fumarate
and acetylsalicylic acid.
The other ingredients are maize starch, cellulose
microcrystalline, magnesium stearate, stearic
acid, polyvinyl alcohol hydrolysed, titanium dioxide
(E171), talc, lecithin (soya) (E322), xanthan gum.
Capsule: gelatin, titanium dioxide (E171)
Printing ink: Shellac, iron oxide black (E172)
propylene glycol, ammonium hydroxide.

What Bisoprolol and Aspirin capsules
look like and contents of pack
The capsules are white with the strength printed on
Bisoprolol and Aspirin 5 mg/75 mg and 10 mg/75
mg capsules are supplied in packs of 14, 28, 30
and 90 capsules.
Bisoprolol and Aspirin 5 mg/100 mg and 10
mg/100 mg capsules are supplied in packs of 10,
14, 28, 30, 56, 60, 90, 98 and 100 capsules.
Not all pack sizes may be marketed
Marketing authorization holder:
ASA Pharma PLC
6 Northbrook Road
Dublin 6, Ireland.
Manufacturer :
Pharmaceutical Works Polpharma S.A
19, Pelplinska Str., 83-200 Starogard,
Gdanski, Poland
This leaflet was last revised in: March 2014

Expand view ⇕

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.