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BENDROFLUMETHIAZIDE 2.5MG TABLETS

Active substance(s): BENDROFLUAZIDE / BENDROFLUMETHIAZIDE

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daily as a single dose or in two divided daily doses, adjusted according to
response.

5 015915 902023

For oral administration,
as directed by the
doctor.
For further information,
see Patient Information
Leaflet.

Bendroflumethiazide

KEEP OUT OF THE
REACH AND SIGHT
OF CHILDREN

2.5mg Tablets

Do not store above
25°C. Keep container
tightly closed.

Each tablet contains:
Bendroflumethiazide
2.5mg.
Also contains lactose.

PL 04416/0529
Sandoz Ltd,
Woolmer Way, Bordon,
Hants, GU35 9QE.

500 tablets





AFTER TAKING THIS MEDICINE
POM

SZ90203LL01A

Page 1



Elderly:
The dosage may need to be reduced, particularly when the patient is suffering from
kidney disease.
Your doctor will decide the dose that is best for you. The pharmacist’s label will
also tell you how many tablets to take and how often. If you are not sure about
anything ask your doctor or pharmacist.
Do not stop taking this medicine without consulting your doctor.
Try to take your medicine at the same time every day. If you miss a dose of this
medicine, take it as soon as possible. However, if it is almost time for your next
dose, skip the missed dose and continue with the regular dosing schedule. DO NOT
DOUBLE THE DOSES.
If you think you have taken too many tablets, contact your doctor straight away or
go to the nearest hospital casualty department. Take with you any remaining
tablets and the container so that the medicine can be identified.

with the needed effects, this medicine may cause side effects in certain
• Along
patients. The more common side effects are impotence
(difficulty in maintaining an erection); mild loss of appetite and

Page 6



indigestion may also occur but these can be reduced by taking the tablets during a
meal or immediately after eating. Other side effects include hypersensitivity
reactions such as pneumonitis (inflammation of the lungs), skin sensitive to light,
joint pain, lower back or side pain, disturbances of electrolyte and acid/base balance,
lipids, uric acid levels, nausea, vomiting, diarrhoea, constipation, thirst and excretion
of excessive amounts of urine, dark urine, light-coloured stools; difficult, noisy, fast
breathing, sometimes with wheezing; blue lips and fingernails, pale skin, increased
sweating, dry mouth, increased thirst, irregular heartbeat, mood or mental changes,
muscle pain, weak pulse, convulsions, swollen glands, itching, weakness, dizziness,
muscle cramps, decreased sexual ability, gout, light-headedness and, in patients
with liver disease, hepatic encephalopathy (disorder of the nervous system
characterised by tremor and musty odour of breath) may occur. Rare side effects
are skin reactions, pancreatitis (inflammation of the pancreas causing abdominal
pain, back pain, fever and rapid pulse rate) and changes to blood cells. If you get a
bad sore throat or high temperature or become more tired and pale, or you bruise or
have nose bleeds more frequently, contact your doctor immediately.
As with all thiazides, Bendroflumethiazide increases the loss of potassium in the
urine which can cause a variety of symptoms such as weakness and confusion.
This imbalance can be corrected by taking potassium supplements or potassium
sparing diuretics. A diet that is rich in potassium (fresh fruit and vegetables) may
be helpful.

Page 7

will need to have regular blood tests to check your levels of potassium
• You
and other electrolytes while you are taking Bendroflumethiazide.
your doctor if any of these symptoms persist or become troublesome.
• Consult
your doctor straight away if you get a rash for the first time after taking the
• Tell
medicine as it may be a sign of allergy.
your doctor or pharmacist if you notice any other unusual or unexpected
• Tell
symptoms.

STORING THIS MEDICINE

• Do not store above 25°C. Keep container tightly closed.
ALL MEDICINES OUT OF THE REACH AND SIGHT OF CHILDREN.
• KEEP
your doctor tells you to, do not keep any tablets that you no longer
• Unless
need. Return them to the pharmacist.
this medicine is for YOU. Do not give it to anyone else, even if
• Remember
their symptoms are the same as yours. This medicine may harm them.
• Do not take the tablets if the expiry date on the label has passed.
Date of revised leaflet: June 2006

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PATIENT INFORMATION LEAFLET

Bendroflumethiazide 2.5mg Tablets
Please read this leaflet carefully before you start taking your tablets. If
you have any questions or are not sure about anything, ask your doctor
or pharmacist.

WHAT YOU SHOULD KNOW ABOUT THIS MEDICINE
The active ingredient in this medicine is bendroflumethiazide. This is the new name
for bendrofluazide. The ingredient has not changed.

alone or in combination with other drugs which lower blood pressure.

WHAT YOU SHOULD CHECK BEFORE TAKING THIS MEDICINE
not take this medicine if you are allergic to Bendroflumethiazide or any of the
• Do
ingredients listed above.
not take this medicine if you have Addison’s disease (underactive adrenal gland),
• Do
hyponatraemia (low levels of sodium in the blood), refractory hypokalaemia (long-term

Pharma Ltd, Units 3 & 4 Quidhampton Business Units, Polhampton Lane,
Overton, Hants, RG25 3ED.
This medicine belongs to a group of drugs known as thiazide diuretics. These are

problems with low levels of potassium in the blood), hypercalcaemia (high levels of
calcium in the blood), symptomatic hyperuricaemia (high levels of uric acid in the
blood), acute porphyria (blood metabolism disorder) or if you have long-term kidney or
liver problems.
Tell your doctor or pharmacist if you are taking any other medicines, including any
that you can buy without a prescription. This is particularly important if you are
taking medicines known as non-steroidal anti-inflammatory drugs such as
indometacin, ketorolac, ibuprofen, diclofenac or mefenamic acid; sulphonylureas
e.g. chlorpropamide, glipizide and glibenclamide for diabetes; ulcer healing drugs
such as carbenoxolone; pain relieving opiates such as levacetylmethadol; lithium,
calcium salts, vitamin D, amphotericin, triamterene, theophylline, carbamazepine,
terfenadine, pimozide; alprostadil, barbiturates, cisplatin, aminoglutethimide,

Page 2

Page 3

Tablets contain 2.5mg of Bendroflumethiazide as the active
• Bendroflumethiazide
ingredient. They also contain the following other ingredients: lactose, maize
starch and magnesium stearate.
medicine is available in pack sizes of 28, 56, 84, 112 or 500 tablets.
• This
product licence holder of this medicine is: Sandoz Ltd, Woolmer Way,
• The
Bordon, Hants, GU35 9QE. The manufacturer of this medicine is: Crescent



used for increasing water loss through the kidneys; this makes you pass more water.
medicine is used for reducing swelling of any part of the body caused by heart,
• This
liver or kidney conditions and is frequently used to treat high blood pressure, either








toremifene, moxisylyte; medicines for high blood pressure including prazosin; cardiac
glycosides such as digoxin; amiodarone, disopyramide, flecainide, quinidine,
lidocaine and mexiletine; tricyclic antidepressants such as amitriptyline and
reboxetine; beta-blockers such as sotalol; medicines known as calcium-channel
blockers such as verapamil; corticosteroids such as prednisolone; baclofen,
tizanidine and non-depolarising neuromuscular blocking drugs such as
pancuronium and atracurium; oestrogens and combined oral contraceptives;
acetazolamide and loop diuretics such as furosemide; beta2 agonists such as
bambuterol, fenoterol, formoterol, reproterol, ritodrine, salmeterol, tulobuterol, and
salbutamol or terbutaline.
Consult your doctor before taking this medicine if you have diabetes, gout,
porphyria (blood metabolism disorder), pancreatitis (inflammation of the
pancreas), hypercalcaemia (excessive calcium in the blood), systemic lupus
erythematosus (a destructive skin condition), enlarged prostate, hyperlipidaemia
(excessive fat in the blood), alcohol related liver problems, other liver problems,
kidney problems or if you have severe asthma and are also taking beta2 agonist
medicines such as salbutamol or terbutaline, or if you are pregnant or are breast
feeding.
If you are going for an operation you should tell the doctor or dentist that you are taking
this medicine.
Alcohol consumption should be kept low as Bendroflumethiazide increases the

Page 4

likelihood of dehydration and hangover after consumption of alcohol.
the anion-exchange resin medicine colestyramine or colestipol, do
• Ifnotyoutakeareattaking
the same time as your Bendroflumethiazide medicine. Instead, take
them 2 hours apart.
you have been told by your doctor that you have an intolerance to some sugars,
• Ifcontact
your doctor before taking this medicine.

HOW TO TAKE THIS MEDICINE

• Swallow the tablets with water.

DOSE:
Adults:
Diuretic (for swelling of any part of the body): initially 5mg to 10mg in the morning
daily or on alternate days. Maintenance: 2.5 to 5mg two or three times a week.
Antihypertensive (for lowering blood pressure): 2.5mg in the morning, alone or in
conjunction with other blood pressure lowering agents.
Children:
Diuretic (for swelling of any part of the body): dosage in children may be up to
0.4mg per kg of bodyweight daily initially, reducing to 0.05 to 0.1mg per kg of
bodyweight for maintenance.
Antihypertensive (for lowering blood pressure): 0.05 to 0.4mg per kg of bodyweight

Page 5

Each tablet contains:
Bendroflumethiazide
2.5mg.
Also contains lactose.

500 tablets

KEEP OUT OF THE
REACH AND SIGHT
OF CHILDREN
Do not store above
25°C. Keep container
tightly closed.
PL 04416/0529
Sandoz Ltd,
Woolmer Way, Bordon,
Hants, GU35 9QE.

POM

SZ90203LL01A

Expiry Date:

2.5mg Tablets

For further information,
see Patient Information
Leaflet.

Batch No.:

Bendroflumethiazide

5 015915 902023

Peel here to open but do not remove ▲

For oral administration,
as directed by the
doctor.

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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