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ATOVAQUONE/PROGUANIL HYDROCHLORIDE 250 MG/ 100 MG FILM-COATED TABLETS

Active substance(s): ATOVAQUONE / PROGUANIL HYDROCHLORIDE

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Package leaflet: information for the patient
Malarone® 250 mg/ 100 mg film-coated tablets
atovaquone/proguanil hydrochloride
Read all of this leaflet carefully before you start taking this
medicine because it contains important information for you.
- Keep this leaflet. You may need to read it again.
- If you have any further questions, ask your doctor or pharmacist.
- This medicine has been prescribed for you only. Do not pass it
on to others. It may harm them, even if their signs of illness are
the same as yours.
- If you get any side effects, talk to your doctor or pharmacist. This
includes any possible side effects not listed in this leaflet. See
section 4.
The name of your medicine is Malarone 250 mg/ 100 mg Filmcoated Tablets but will be referred to as Malarone throughout the
remainder of this leaflet.
What is in this leaflet:
1. What Malarone is and what it is used for
2. What you need to know before you take Malarone
3. How to take Malarone
4. Possible side effects
5. How to store Malarone
6. Contents of the pack and other information
1. What Malarone is and what it is used for
Malarone belongs to a group of medicines called antimalarials. It
contains two active ingredients, atovaquone and proguanil
hydrochloride.
What Malarone is used for
Malarone has two uses:
• to prevent malaria
• to treat malaria
Dosage instructions for each use are in Section 3, How to take
Malarone.
Malaria is spread by the bite of an infected mosquito, which passes
the malaria parasite (Plasmodium falciparum) into the bloodstream.
Malarone prevents malaria by killing this parasite. For people who
are already infected with malaria, Malarone also kills these
parasites.
Protect yourself from catching malaria
People of any age can get malaria. It is a serious disease, but is
preventable.
As well as taking Malarone, it is very important that you also take
steps to avoid being bitten by mosquitoes.



Use insect repellent on exposed areas of the skin
Wear light coloured clothing that covers most of the body,
especially after sunset as this is the time when mosquitoes are
most active
• Sleep in a screened room or under a mosquito net
impregnated with insecticide
• Close windows and doors at sunset, if they are not screened
• Consider using an insecticide (mats, spray, plug-ins) to clear
a room of insects or to deter mosquitoes from entering the room.
 If you need further advice, talk to your doctor or pharmacist.
It is still possible to get malaria after taking the necessary
precautions. Some types of malaria infection take a long time to
cause symptoms, so the illness may not start until several days,
weeks or even months after returning from abroad.
 See a doctor immediately if you get symptoms such as high
temperature, headache, shivering and tiredness after returning
home.
2. What you need to know before you take Malarone
Do not take Malarone:


if you are allergic to atovaquone, proguanil hydrochloride or
any of the ingredients of this medicine listed in section 6.
• for preventing malaria, if you have severe kidney disease.
 Tell your doctor if either of these apply to you.
Take special care with Malarone
Talk to your doctor or pharmacist before taking Malarone if:



you have severe kidney disease
your child is being treated for Malaria and weighs less than 11
kg. There is another tablet strength to treat children who weigh
less than 11 kg (see section 3).
 Tell your doctor or pharmacist if any of these applies to you.

Other medicines and Malarone
Tell your doctor or pharmacist if you are taking, have recently
taken, or might take any other medicines, including medicines
you’ve bought without a prescription.
Some medicines can affect the way Malarone works, or Malarone
itself can strengthen or weaken the effectiveness of other medicines
taken at the same time. These include:




metoclopramide, used to treat nausea and vomiting
the antibiotics, tetracycline, rifampicin and rifabutin
efavirenz or certain highly active protease-inhibitors used to
treat HIV
• warfarin and other medicines that stop blood clotting
• etoposide used to treat cancer.
 Tell your doctor if you are taking any of these. Your doctor may
decide that Malarone isn’t suitable for you, or that you need
extra check-ups while you’re taking it.
 Remember to tell your doctor if you start taking any other
medicines while you’re taking Malarone.
Malarone with food and drink
Take Malarone with food or a milky drink, where possible. This
will increase the amount of Malarone your body can absorb, and
make your treatment more effective.
Pregnancy and breast-feeding
If you are pregnant, do not take Malarone unless your doctor
recommends it.
 Ask your doctor or pharmacist for advice before taking Malarone
Do not breast-feed while taking Malarone, as the ingredients of
Malarone may pass into breast milk and may harm your baby.
Driving and using machines
If you feel dizzy, do not drive.
Malarone makes some people feel dizzy. If this happens to you, do
not drive, use machines or take part in activities where you may put
yourself or others at risk.
3. How to take Malarone
Always take this medicine exactly as your doctor or pharmacist
has told you. Check with your doctor or pharmacist if you are not
sure.
Take Malarone with food or a milky drink, where possible.
It is best to take Malarone at the same time each day.
If you are sick (vomit)
For preventing malaria:


if you are sick (vomit) within 1 hour of taking your Malarone
tablet, take another dose straight away
• it is important to take the full course of Malarone. If you have
to take extra tablets due to sickness, you may need another
prescription.
• if you have been vomiting, it is especially important to use
extra protection, such as repellents and bed nets. Malarone may
not be as effective, as the amount absorbed will be reduced.
For treating malaria


if you have vomiting and diarrhoea tell your doctor, you will
need regular blood tests. Malarone will not be as effective, as
the amount absorbed will be reduced. The tests will check
whether the malaria parasite is being cleared from your blood.
To prevent malaria:
The recommended usual dose for adults is 1 tablet once a day,
taken as below.
Not recommended for preventing malaria in children, or in adults
who weigh less than 40 kgs. Malarone paediatric tablets are
recommended for preventing malaria in adults and children who
weigh less than 40 kgs.
To prevent malaria in adults:





start taking Malarone 1 to 2 days before travelling to an area
which has malaria
continue taking it every day during your stay
continue taking it for another 7 days after your return to a
malaria-free area.

To treat malaria
The recommended dose for adults is 4 tablets once a day for 3
days.
For children the dose depends on their bodyweight:
• 11-20 kg – 1 tablet once a day for 3 days
• 21-30 kg – 2 tablets once a day for 3 days
• 31-40 kg – 3 tablets once a day for 3 days
• over 40 kg – dose as for adults.
Not recommended for treating malaria in children who weigh
less than 11 kgs.
For children who weigh less than 11 kgs talk to your doctor. There
may be a different type of Malarone tablet available in your country.
If you take more Malarone than you should
Contact a doctor or pharmacist for advice. If possible show them the
Malarone pack.
If you forget to take Malarone
It is very important that you take the full course of Malarone.
If you forget to take a dose, don’t worry. Just take your next dose as
soon as you remember. Then continue your treatment as before.
Don’t take extra tablets to make up for a missed dose. Just take
your next dose at the usual time.
Don’t stop taking Malarone without advice
Keep taking Malarone for 7 days after you return to a malariafree area. Take the full course of Malarone for maximum protection.
Stopping early puts you at risk of getting malaria, as it takes 7 days
to ensure that any parasites that may be in your blood following a
bite from an infected mosquito are killed.
If you have any further questions on the use of this medicine, ask
your doctor or pharmacist.
4. Possible side effects
Like all medicines, this medicine can cause side effects, although
not everybody gets them.
Look out for the following severe reactions. They have occurred in a
small number of people, but their exact frequency is unknown.
Severe allergic reactions – signs include:



rash and itching
sudden wheezing, tightness of the chest or throat, or difficulty
breathing
• swollen eyelids, face, lips, tongue or other part of the body.
 Contact a doctor immediately if you get any of these
symptoms. Stop taking Malarone.
Severe skin reactions


skin rash, which may blister and looks like small targets (central
dark spots, surrounded by paler area with a dark ring around the
edge) (erythema multiforme)
• severe widespread rash with blisters and peeling skin,
particularly occurring around the mouth, nose, eyes and genitals
(Stevens-Johnson syndrome).
 If you notice any of these symptoms contact a doctor
urgently.
Most of the other side effects reported have been mild and have not
lasted very long.
Very common side effects
These may affect more than 1 in 10 people:
• headache
• feeling sick and being sick (nausea and vomiting)
• stomach pain
• diarrhoea.
Common side effects
These may affect up to 1 in 10 people:
• dizziness
• sleeping problems (insomnia)
• strange dreams
• depression
• loss of appetite
• fever
• rash which may be itchy
• cough
Common side effects, which may show up in your blood tests are:





reduced numbers of red blood cells (anaemia) which can cause
tiredness, headaches and shortness of breath
reduced numbers of white blood cells (neutropenia) which may
make you more likely to catch infections
low levels of sodium in the blood (hyponatraemia)
an increase in liver enzymes.

Uncommon side effects
These may affect up to 1 in 100 people:
• anxiety
• an unusual awareness of abnormal beating of the heart
(palpitations)
• swelling and redness of the mouth
• hair loss.
Uncommon side effects that may show up in your blood tests:
• an increase in amylase (an enzyme produced in the pancreas).
Rare side effects
These may affect up to 1 in 1,000 people:
• seeing or hearing things that are not there (hallucinations)
Other side effects


other side effects have occurred in a small number of people but
their exact frequency is unknown.
• inflammation of the liver(hepatitis)
• blockage of the bile ducts (cholestatis)
• increase in heart rate (tachycardia)
• inflammation of the blood vessels (vasculitis) which may be
visible as red or purple raised spots on the skin but can affect
other parts of the body
• fits (seizures)
• panic attacks, crying
• nightmares
• severe mental health problem in which the person loses contact
with reality and is unable to think and judge clearly
• mouth ulcers
• blisters
• peeling skin
• increased sensitivity of the skin to sunlight.
Other side effects that may show up in your blood tests:
• A decrease in all types of blood cells (pancytopenia).
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse.
This includes any possible side effects not listed in this leaflet. You
can also report side effects directly via the Yellow Card Scheme at:
www.mhra.gov.uk/yellowcard.
By reporting side effects you can help provide more information on
the safety of this medicine.

5. How to store Malarone
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date shown on the
carton. The date refers to the last day of the month.
Malarone does not require any special storage conditions.
Do not throw away any medicines via wastewater or household
waste. Ask your pharmacist how to throw away medicines you no
longer use. This will help protect the environment.
If your medicine become discoloured or deteriorates then seek
medical advice from a doctor or pharmacist
6. Contents of the pack and other information
What Malarone contains
Each film-coated tablet contains 250mg of atovaquone and 100 mg
of proguanil hydrochloride.
The other ingredients are:
tablet core: poloxamer 188, microcrystalline cellulose, hydroxypropyl
cellulose (E463), povidone K30 (E1201), sodium starch glycollate
(Type A), magnesium stearate (E470B)
tablet coating: hypromellose, titanium dioxide (E171), iron oxide red
(E172), macrogol 400 and polyethylene glycol 8000
 Tell your doctor, without taking Malarone if you might be
allergic to any of these ingredients.
What Malarone looks like and contents of the pack
Malarone tablets are round, pink film-coated tablets engraved ‘GX
CM3’ on one side. They are supplied in blister packs containing 12
tablets.
Manufacturer
Glaxo Wellcome S.A, Avenue Extremadura, 3, 09400 Aranda de
Duero, Burgos, Spain
Procured from within the E.U. by
Product Licence holder: Ecosse Pharmaceuticals Ltd., 3 Young
Place, East Kilbride, G75 0TD and re-packaged by Munro Wholesale
Medical Supplies Ltd., 3 Young Place, East Kilbride, G75 0TD.
PL 19065/0439
This leaflet was revised: 30/09/2014
POM
E0439L-1
Malarone® is a registered trademark of the GlaxoSmithKline group of companies.

Package leaflet: information for the patient
Atovaquone/Proguanil hydrochloride
250 mg/ 100 mg film-coated tablets
Read all of this leaflet carefully before you start taking this
medicine because it contains important information for you.
- Keep this leaflet. You may need to read it again.
- If you have any further questions, ask your doctor or pharmacist.
- This medicine has been prescribed for you only. Do not pass it
on to others. It may harm them, even if their signs of illness are
the same as yours.
- If you get any side effects, talk to your doctor or pharmacist. This
includes any possible side effects not listed in this leaflet. See
section 4.
The name of your medicine is Atovaquone/ Proguanil Hydrochloride
250 mg /100 mg Film-coated Tablets but will be referred to as
Atovaquone/ Proguanil Hydrochloride throughout the remainder of
this leaflet.
What is in this leaflet:
1. What Atovaquone/proguanil hydrochloride is and what it is
used for
2. What you need to know before you take
Atovaquone/proguanil hydrochloride
3. How to take Atovaquone/proguanil hydrochloride
4. Possible side effects
5. How to store Atovaquone/proguanil hydrochloride
6. Contents of the pack and other information
1. What Atovaquone/proguanil hydrochloride is and what it is
used for
Atovaquone/proguanil hydrochloride belongs to a group of medicines
called antimalarials. It contains two active ingredients, atovaquone
and proguanil hydrochloride.
What Atovaquone/proguanil hydrochloride is used for
Atovaquone/proguanil hydrochloride has two uses:



to prevent malaria
to treat malaria

Dosage instructions for each use are in Section 3, How to take
Atovaquone/proguanil hydrochloride.
Malaria is spread by the bite of an infected mosquito, which passes
the malaria parasite (Plasmodium falciparum) into the bloodstream.
Atovaquone/proguanil hydrochloride prevents malaria by killing this
parasite. For people who are already infected with malaria,
Atovaquone/proguanil hydrochloride also kills these parasites.
Protect yourself from catching malaria
People of any age can get malaria. It is a serious disease, but is
preventable.
As well as taking Atovaquone/proguanil hydrochloride, it is very
important that you also take steps to avoid being bitten by
mosquitoes.



Use insect repellent on exposed areas of the skin
Wear light coloured clothing that covers most of the body,
especially after sunset as this is the time when mosquitoes are
most active
• Sleep in a screened room or under a mosquito net
impregnated with insecticide
• Close windows and doors at sunset, if they are not screened
• Consider using an insecticide (mats, spray, plug-ins) to clear
a room of insects or to deter mosquitoes from entering the room.
 If you need further advice, talk to your doctor or pharmacist.
It is still possible to get malaria after taking the necessary
precautions. Some types of malaria infection take a long time to
cause symptoms, so the illness may not start until several days,
weeks or even months after returning from abroad.
 See a doctor immediately if you get symptoms such as high
temperature, headache, shivering and tiredness after returning
home.
2. What you need to know before you take Atovaquone/
proguanil hydrochloride
Do not take Atovaquone/proguanil hydrochloride:


if you are allergic to atovaquone, proguanil hydrochloride or
any of the ingredients of this medicine listed in section 6.
• for preventing malaria, if you have severe kidney disease.
 Tell your doctor if either of these apply to you.
Take special care with Atovaquone/proguanil hydrochloride
Talk to your doctor or pharmacist before taking
Atovaquone/proguanil hydrochloride if:




you have severe kidney disease
your child is being treated for Malaria and weighs less than 11
kg. There is another tablet strength to treat children who weigh
less than 11 kg (see section 3).

 Tell your doctor or pharmacist if any of these applies to you.
Other medicines and Atovaquone/proguanil hydrochloride
Tell your doctor or pharmacist if you are taking, have recently
taken, or might take any other medicines, including medicines
you’ve bought without a prescription.
Some medicines can affect the way Atovaquone/proguanil
hydrochloride works, or Atovaquone/proguanil hydrochloride itself
can strengthen or weaken the effectiveness of other medicines taken
at the same time. These include:




metoclopramide, used to treat nausea and vomiting
the antibiotics, tetracycline, rifampicin and rifabutin
efavirenz or certain highly active protease-inhibitors used to
treat HIV
• warfarin and other medicines that stop blood clotting
• etoposide used to treat cancer.
 Tell your doctor if you are taking any of these. Your doctor may
decide that Atovaquone/proguanil hydrochloride isn’t suitable for
you, or that you need extra check-ups while you’re taking it.
 Remember to tell your doctor if you start taking any other
medicines while you’re taking Atovaquone/proguanil
hydrochloride.
Atovaquone/proguanil hydrochloride with food and drink
Take Atovaquone/proguanil hydrochloride with food or a milky
drink, where possible. This will increase the amount of
Atovaquone/proguanil hydrochloride your body can absorb, and
make your treatment more effective.
Pregnancy and breast-feeding
If you are pregnant, do not take Atovaquone/proguanil
hydrochloride unless your doctor recommends it.
 Ask your doctor or pharmacist for advice before taking
Atovaquone/proguanil hydrochloride
Do not breast-feed while taking Atovaquone/proguanil
hydrochloride, as the ingredients of Atovaquone/proguanil
hydrochloride may pass into breast milk and may harm your baby.
Driving and using machines
If you feel dizzy, do not drive.
Atovaquone/proguanil hydrochloride makes some people feel dizzy.
If this happens to you, do not drive, use machines or take part in
activities where you may put yourself or others at risk.
3. How to take Atovaquone/proguanil hydrochloride
Always take this medicine exactly as your doctor or pharmacist
has told you. Check with your doctor or pharmacist if you are not
sure.
Take Atovaquone/proguanil hydrochloride with food or a milky drink,
where possible.
It is best to take Atovaquone/proguanil hydrochloride at the same
time each day.
If you are sick (vomit)
For preventing malaria:


if you are sick (vomit) within 1 hour of taking your
Atovaquone/proguanil hydrochloride tablet, take another
dose straight away
• it is important to take the full course of
Atovaquone/proguanil hydrochloride. If you have to take
extra tablets due to sickness, you may need another
prescription.
• if you have been vomiting, it is especially important to use
extra protection, such as repellents and bed nets.
Atovaquone/proguanil hydrochloride may not be as effective, as
the amount absorbed will be reduced.
For treating malaria


if you have vomiting and diarrhoea tell your doctor, you will
need regular blood tests. Atovaquone/proguanil hydrochloride
will not be as effective, as the amount absorbed will be reduced.
The tests will check whether the malaria parasite is being
cleared from your blood.
To prevent malaria:
The recommended usual dose for adults is 1 tablet once a day,
taken as below.
Not recommended for preventing malaria in children, or in adults
who weigh less than 40 kgs. Atovaquone/proguanil hydrochloride
paediatric tablets are recommended for preventing malaria in adults
and children who weigh less than 40 kgs.
To prevent malaria in adults:




start taking Atovaquone/proguanil hydrochloride 1 to 2 days
before travelling to an area which has malaria
continue taking it every day during your stay
continue taking it for another 7 days after your return to a
malaria-free area.

To treat malaria
The recommended dose for adults is 4 tablets once a day for 3
days.
For children the dose depends on their bodyweight:
• 11-20 kg – 1 tablet once a day for 3 days
• 21-30 kg – 2 tablets once a day for 3 days
• 31-40 kg – 3 tablets once a day for 3 days
• over 40 kg – dose as for adults.
Not recommended for treating malaria in children who weigh
less than 11 kgs.
For children who weigh less than 11 kgs talk to your doctor. There
may be a different type of Atovaquone/proguanil hydrochloride tablet
available in your country.
If you take more Atovaquone/proguanil hydrochloride than you
should
Contact a doctor or pharmacist for advice. If possible show them the
Atovaquone/proguanil hydrochloride pack.
If you forget to take Atovaquone/proguanil hydrochloride
It is very important that you take the full course of
Atovaquone/proguanil hydrochloride.
If you forget to take a dose, don’t worry. Just take your next dose as
soon as you remember. Then continue your treatment as before.
Don’t take extra tablets to make up for a missed dose. Just take
your next dose at the usual time.
Don’t stop taking Atovaquone/proguanil hydrochloride without
advice
Keep taking Atovaquone/proguanil hydrochloride for 7 days
after you return to a malaria-free area. Take the full course of
Atovaquone/proguanil hydrochloride for maximum protection.
Stopping early puts you at risk of getting malaria, as it takes 7 days
to ensure that any parasites that may be in your blood following a
bite from an infected mosquito are killed.
If you have any further questions on the use of this medicine, ask
your doctor or pharmacist.
4. Possible side effects
Like all medicines, this medicine can cause side effects, although
not everybody gets them.
Look out for the following severe reactions. They have occurred in a
small number of people, but their exact frequency is unknown.
Severe allergic reactions – signs include:



rash and itching
sudden wheezing, tightness of the chest or throat, or difficulty
breathing
• swollen eyelids, face, lips, tongue or other part of the body.
 Contact a doctor immediately if you get any of these
symptoms. Stop taking Atovaquone/proguanil hydrochloride.
Severe skin reactions


skin rash, which may blister and looks like small targets (central
dark spots, surrounded by paler area with a dark ring around the
edge) (erythema multiforme)
• severe widespread rash with blisters and peeling skin,
particularly occurring around the mouth, nose, eyes and genitals
(Stevens-Johnson syndrome).
 If you notice any of these symptoms contact a doctor
urgently.
Most of the other side effects reported have been mild and have not
lasted very long.
Very common side effects
These may affect more than 1 in 10 people:
• headache
• feeling sick and being sick (nausea and vomiting)
• stomach pain
• diarrhoea.
Common side effects
These may affect up to 1 in 10 people:
• dizziness
• sleeping problems (insomnia)
• strange dreams
• depression
• loss of appetite
• fever
• rash which may be itchy
• cough
Common side effects, which may show up in your blood tests are:





reduced numbers of red blood cells (anaemia) which can cause
tiredness, headaches and shortness of breath
reduced numbers of white blood cells (neutropenia) which may
make you more likely to catch infections
low levels of sodium in the blood (hyponatraemia)
an increase in liver enzymes.

Uncommon side effects
These may affect up to 1 in 100 people:
• anxiety
• an unusual awareness of abnormal beating of the heart
(palpitations)
• swelling and redness of the mouth
• hair loss.
Uncommon side effects that may show up in your blood tests:
• an increase in amylase (an enzyme produced in the pancreas).
Rare side effects
These may affect up to 1 in 1,000 people:
• seeing or hearing things that are not there (hallucinations)
Other side effects


other side effects have occurred in a small number of people but
their exact frequency is unknown.
• inflammation of the liver(hepatitis)
• blockage of the bile ducts (cholestatis)
• increase in heart rate (tachycardia)
• inflammation of the blood vessels (vasculitis) which may be
visible as red or purple raised spots on the skin but can affect
other parts of the body
• fits (seizures)
• panic attacks, crying
• nightmares
• severe mental health problem in which the person loses contact
with reality and is unable to think and judge clearly
• mouth ulcers
• blisters
• peeling skin
• increased sensitivity of the skin to sunlight.
Other side effects that may show up in your blood tests:
• A decrease in all types of blood cells (pancytopenia).
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse.
This includes any possible side effects not listed in this leaflet. You
can also report side effects directly via the Yellow Card Scheme at:
www.mhra.gov.uk/yellowcard.
By reporting side effects you can help provide more information on
the safety of this medicine.
5. How to store Atovaquone/proguanil hydrochloride
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date shown on the
carton. The date refers to the last day of the month.
Atovaquone/proguanil hydrochloride does not require any
special storage conditions.
Do not throw away any medicines via wastewater or household
waste. Ask your pharmacist how to throw away medicines you no
longer use. This will help protect the environment.
If your medicine become discoloured or deteriorates then seek
medical advice from a doctor or pharmacist.
6. Contents of the pack and other information
What Atovaquone/proguanil hydrochloride contains
Each film-coated tablet contains 250mg of atovaquone and 100 mg
of proguanil hydrochloride.
The other ingredients are:
tablet core: poloxamer 188, microcrystalline cellulose, hydroxypropyl
cellulose (E463), povidone K30 (E1201), sodium starch glycollate
(Type A), magnesium stearate (E470B)
tablet coating: hypromellose, titanium dioxide (E171), iron oxide red
(E172), macrogol 400 and polyethylene glycol 8000.
 Tell your doctor, without taking Atovaquone/proguanil
hydrochloride if you might be allergic to any of these
ingredients.
What Atovaquone/proguanil hydrochloride looks like and
contents of the pack
Atovaquone/proguanil hydrochloride tablets are round, pink filmcoated tablets engraved ‘GX CM3’ on one side. They are supplied in
blister packs containing 12 tablets.
Manufacturer
Glaxo Wellcome S.A, Avenue Extremadura, 3, 09400 Aranda de
Duero, Burgos, Spain
Procured from within the E.U. by
Product Licence holder: Ecosse Pharmaceuticals Ltd., 3 Young
Place, East Kilbride, G75 0TD.
Re-packaged by Munro Wholesale Medical Supplies Ltd., 3 Young
Place, East Kilbride, G75 0TD.
PL 19065/0439
This leaflet was revised: 30/09/2014
E0439(ap)-1

POM

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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