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AMPITRIN 500MG CAPSULES
Active substance(s): AMPICILLIN TRIHYDRATE
PACKAGE LEAFLET - INFORMATION FOR THE PATIENT
AMPICILLIN 250mg AND 500mg CAPSULES
Please read this leaflet carefully before you start taking this medicine because it contains
important information for you.
• Keep this leaflet. You may need to read it again.
• If you have further questions, please ask your doctor or your pharmacist.
• This medicine has been prescribed for you only. Do not pass it on to others. It may harm
them, even if their symptoms are the same as yours.
• If you get any side effects, talk to your doctor or pharmacist. This includes any side effects
not listed in this leaflet. See section 4.
WHAT IS IN THIS LEAFLET
1. What Ampicillin Capsules are and what they are used for
2. What you need to know before you take Ampicillin Capsules
3. How to take Ampicillin Capsules
4. Possible side effects
5. How to store Ampicillin Capsules
6. Contents of the pack and other information
WHAT AMPICILLIN CAPSULES ARE
AND WHAT THEY ARE USED FOR
The name of your medicine is Ampicillin
Capsules. It belongs to a group of medicines
called broad spectrum antibiotics. It is used to kill
bacteria that cause infections in your body.
These infections include:
• Respiratory tract infections (e.g. infections of
the nose and throat, pneumonia, bronchitis)
• Infections of the ear
• Urinary tract infections (e.g. infections of the
bladder and urethra)
• Gastro-intestinal infections (e.g. infections of
• Enteric/Typhoid fever (an infectious disease
contracted by eating food or drinking water
contaminated with Salmonella)
• Gynaecological infections and Gonorrhoea (a
sexually transmitted disease).
• Infections of the blood (Septicaemia)
• Skin and soft tissue (e.g. Acne)
• To prevent endocarditis (inflammation of the
lining of the heart and its valves) after surgery
or a dental procedure
• Peritonitis (an inflammation of the peritoneum,
the thin tissue that lines the inner wall of the
• Meningitis (inflammation of the protective
membranes covering the brain and spinal cord)
WHAT YOU NEED TO KNOW BEFORE
YOU TAKE AMPICILLIN CAPSULES
Do not take this medicine if you:
• have ever had an allergic reaction to
Ampicillin, beta lactam antibiotics or any other
penicillin or cephalosporin-type antibiotics (see
symptoms in section 4, Possible side effects)
• have ever had an allergic reaction to any of
the other ingredients of this medicine (see list
of ingredients in section 6, Contents of the
pack and other information).
Warnings and precautions
Talk to your doctor or pharmacist before taking
your medicine if you:
• suffer from kidney problems as you may
require a lower dose than normal
• are suffering from glandular fever or
cytomegalovirus (CMV) infection
• are suffering from lymphatic leukaemia
Other medicines and Ampicillin Capsules
Your medicine may interfere with other
medicines you are taking. Please inform your
doctor or your pharmacist if you are taking, or
have recently taken, any other medicines even
those not prescribed - especially any of the
• Allopurinol, sulfinpyrazone or probenecid
(used to treat gout)
• Tetracycline, erythromycin and
chloramphenicol (other types of antibiotics)
• Anticoagulants e.g. warfarin or phenindione
• Cytotoxic drugs e.g. methotrexate (used to
treat rheumatoid arthritis, psoriasis, or
malignant diseases such as lymphatic
• Chloroquine (used for prevention and
treatment of malaria)
• Oral typhoid vaccine (used to prevent typhoid)
• The oral contraceptive pill, Ampicillin may
interfere with the action of the contraceptive
pill. Therefore additional contraceptive
measures should be taken during and for 7
days after taking this medicine.
While you are taking Ampicillin, the results of
certain medical tests could be affected. If you are
having blood or urine tests, please tell your
doctor that you are taking Ampicillin.
Pregnancy and breastfeeding
If you are pregnant or breastfeeding, think you
may be pregnant or are planning to have a baby
ask your doctor or pharmacist for advice before
taking any medicine.
HOW TO TAKE AMPICILLIN CAPSULES
Always take this medicine exactly as described
in this leaflet or as your doctor or pharmacist has
told you. Check with your doctor or pharmacist if
you are not sure. The capsules should be taken
orally on an empty stomach, at least thirty
minutes to one hour before meals/food. It is
important that you take your medicine at the right
The dose will depend on the patient and will be
decided by your doctor. However, the usual
doses for each illness are:
Adults (including the elderly)
• Ear, nose and throat
- 250mg four times daily
- 250mg four times daily. This may be
increased to 1 gram four times daily in
- 500mg four times daily
• Urinary tract infections
- 500mg three times daily
• Gastro-intestinal infections
- 500 - 750mg three to four times daily.
• Typhoid fevers
- Acute: 1 - 2 grams four times daily for 2
- Carriers: 1 - 2 grams four times daily for 4 to
- 2 grams orally with 1 gram of probenecid as
a single dose. A repeated dose may be
necessary in females.
The dosage may be reduced in patients with
severe kidney failure.
Children under 10 years
Children usually take half the adult dose.
Customer: AT Originated by: AWG
Product: Ampicillin JNT Capsules
Dimensions: 148mm x 335mm
Item Code: CP.AMP.JNT.C.AT.V2P2
Proof No and Date: 2 21/07/14
ARTWORK FOR SUBMISSION
If you take more of your medicine than you
If you (or somebody else) accidentally takes too
much of your medicine, speak to your doctor or
If you forget to take your medicine
If you forget to take a dose, take it as soon as
you remember, then carry on as before. Do not
take a double dose to make up for the dose you
If you stop taking your medicine
Keep taking your medicine until your doctor tells
you to stop. Do not stop taking it just because
you feel better. If you stop taking the medicine,
your infection may return or get worse. If you are
still unwell after taking all the medicine, go and
see your doctor.
POSSIBLE SIDE EFFECTS
Like all medicines, Ampicillin can cause side
effects, although not everybody gets them. If
they occur, they are likely to be temporary, and
not serious. However, some may be serious and
need medical attention.
If you experience any of the following events
STOP taking your medicine and tell your
doctor or go to your nearest hospital
• Hypersensitivity or severe allergic reaction
called anaphylaxis, which causes difficulty
• Swelling of the lips, cheeks, tongue and
• Skin rash, itching or any other skin trouble,
such as blisters and swollen red patches or
hives. These reactions may occur if you have
glandular fever, cytomegalovirus (CMV)
infection or lymphatic leukaemia and are also
• Yellowing of the whites of the eyes and skin
• Difficulty or discomfort in passing urine, having
blood in the urine or lower back pain (may be
a sign of kidney inflammation)
• Pseudomembranous colitis (severe
diarrhoea which may contain blood or
The following events are less serious but you
may wish to discuss them with your doctor or
pharmacist if they become troublesome or
last a long time
wastewater or household waste. Ask your
pharmacist how to throw away medicines you no
longer use. These measures will help protect the
CONTENTS OF THE PACK AND
What Ampicillin Capsules contain
Active ingredient: ampicillin as ampicillin
Other ingredients: magnesium stearate and
gelatin (black iron oxide (E172), quinoline yellow
(E104), titanium dioxide (E171), patent blue V
(E131) and erythrosine (E127) as colouring
What Ampicillin Capsules look like and
contents of the pack
250mg Capsule - red and grey capsule with
‘AMP 250’ printed on it.
500mg Capsule - red and grey capsule with
‘AMP 500’ printed on it.
Both strengths are available in the following
Tubs are available in pack sizes of 15, 18, 20,
21, 28, 30, 50, 100 & 500 capsules.
Blister packs are available in pack sizes of 15,
18, 20, 21, 28, 30, 50, 100 & 500 capsules.
The 250mg capsule is also available in pack size
The 500mg capsule is also available in pack size
16 in blisters.
Not all pack sizes may be marketed.
The manufacturer and licence holder
Athlone Laboratories Limited,
Telephone: 00 353 (0) 90 666 1109
Fax: 00 353 (0) 90 666 1921
Kent Pharmaceuticals Limited,
DE12 7DT, U.K.
This leaflet was last revised July 2014.
Common side effects (i.e. have been reported
in more than 1 in 100 people) include:
• Nausea and vomiting (feeling and being sick).
Very rare side effects (i.e. have been reported
in less than 1 in 10,000 people) include:
• Temporary blood disorders that could cause
you to have more infections such as fever,
severe chills, sore throat, mouth ulcers or
bruising more easily. It can also cause
anaemia, this can make your skin pale, cause
weakness, breathlessness and tiredness.
Reporting of side effects
If you get any side effects, talk to your doctor or
pharmacist. This includes any possible side
effects not listed in this leaflet. You can also
report side effects directly via the yellow card
scheme at www.mhra.gov.uk/yellowcard. By
reporting side effects you can help provide more
information on the safety of this medicine.
HOW TO STORE AMPICILLIN
Store below 25°C. Protect from light and
moisture. Store in the original package.
KEEP THIS MEDICINE OUT OF THE SIGHT
AND REACH OF CHILDREN.
Do not use this medicine after the expiry date
shown on the label.
Return any left-over medicine to the pharmacist.
Do not throw away any medicines via