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AMPITRIN 125MG/5ML ORAL SUSPENSION

Active substance(s): AMPICILLIN TRIHYDRATE

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CP.AMP.JNT.Su.AT.V2P3
Co 97

PACKAGE LEAFLET - INFORMATION FOR THE PATIENT

AMPICILLIN 125mg/5ml AND
250mg/5ml ORAL SUSPENSION
Please read all of this leaflet carefully before you start taking this medicine because it contains
important information for you.
• Keep this leaflet. You may need to read it again.
• If you have further questions, please ask your doctor or pharmacist (chemist).
• This medicine has been prescribed for you only. Do not pass it on to others. It may harm
them, even if their symptoms are the same as yours.
• If you get any side effects, talk to your doctor or pharmacist. This includes any side effects
not listed in this leaflet. See section 4.
WHAT IS IN THIS LEAFLET
1. What Ampicillin Oral Suspension is and what it is used for
2. What you need to know before you take Ampicillin Oral Suspension
3. How to take Ampicillin Oral Suspension
4. Possible side effects
5. How to store Ampicillin Oral Suspension
6. Contents of the pack and other information

1.

WHAT AMPICILLIN ORAL SUSPENSION
IS AND WHAT IT IS USED FOR

The name of your medicine is Ampicillin Oral
Suspension. It belongs to a group of medicines
called broad spectrum antibiotics. It is used to kill
bacteria that cause infections in your body.
These infections include:
• Respiratory tract infections (e.g. infections of
the nose and throat, pneumonia and
bronchitis)
• Infections of the ear
• Urinary tract infections (e.g. infections of the
bladder and urethra)
• Gastro-intestinal infections (e.g. infections of
the intestines)
• Enteric/Typhoid fever (infectious disease
contracted by eating food or drinking water
contaminated with Salmonella)
• Gynaecological infections and Gonorrhoea (a
sexually transmitted disease)
• Infections of the blood (Septicaemia)
• Skin and soft tissue (e.g. Acne)
• To prevent endocarditis (inflammation of the
lining of the heart and its valves) after surgery
or a dental procedure
• Peritonitis (an inflammation of the peritoneum,
the tissue that lines the inner wall of the
abdomen)
• Meningitis (inflammation of the protective
membranes covering the brain and spinal cord)

2.

WHAT YOU NEED TO KNOW BEFORE
YOU TAKE AMPICILLIN ORAL
SUSPENSION

Do not take this medicine if:
• You have ever had an allergic reaction to
Ampicillin, beta lactam antibiotics or any other
penicillin or cephalosporin-type antibiotics (see
symptoms in Section 4, Possible side effects)
• You have ever had an allergic reaction to any
of the other ingredients of this medicine (see
list of ingredients in Section 6, Contents of the
pack and other information).
Warnings and precautions
Talk to your doctor or pharmacist before taking
your medicine if:
• You suffer from kidney problems as you may
require a lower dose than normal
• You are suffering from glandular fever or
cytomegalovirus (CMV) infection
• You are suffering from lymphatic leukaemia,
HIV or syphilis.
Other medicines and Ampicillin Oral
Suspension
Your medicine may affect the way other
medicines work. Please inform your doctor or
your pharmacist if you are taking or have
recently taken any other medicines, including
medicines obtained without prescription,
especially the following:
• Allopurinol, sulfinpyrazone or probenecid
(used to treat gout)
• Tetracycline, erythromycin and
chloramphenicol (other types of antibiotics)
• Anticoagulants e.g. warfarin or phenindione

• Cytotoxic drugs e.g. methotrexate (used to
treat rheumatoid arthritis, psoriasis, or
malignant diseases such as lymphatic
leukaemia)
• Chloroquine (used for prevention and
treatment of malaria)
• Oral typhoid vaccine (used to prevent typhoid)
• The oral contraceptive pill, Ampicillin may
interfere with the action of the contraceptive
pill. Therefore additional contraceptive
measures should be taken during and for 7
days after taking this medicine.
Tests
While you are taking Ampicillin, the results of
certain medical tests could be affected. If you are
having blood or urine tests, please tell your
doctor that you are taking Ampicillin.
Pregnancy and breastfeeding
If you are pregnant or breastfeeding, think you
may be pregnant or are planning to have a baby,
ask your doctor or pharmacist for advice before
taking any medicine.
Important information about some of the
ingredients in your medicine
This medicine contains up to 1.937g of sucrose
(sugar) per 5ml dose. If you have been told by
your doctor that you have an intolerance to some
sugars, contact your doctor before taking this
medicinal product.
Ponceau 4R (E124) can cause allergic-type
reactions including asthma. Allergy is more
common in patients who are allergic to aspirin.

3.

HOW TO TAKE AMPICILLIN ORAL
SUSPENSION

Always take this medicine exactly as described
in this leaflet or as your doctor or pharmacist has
told you. Check with your doctor or pharmacist if
you are not sure. Take your medicine on an
empty stomach, at least thirty minutes to one
hour before meals/food. It is important that you
take your medicine at the right times.
The dose will depend on the patient and will be
decided by your doctor. However, the usual
doses for each illness are:
Adults (including the elderly)
• Ear, nose and throat
- 250mg four times daily
• Bronchitis
- 250mg four times daily. This may be increased
to 1 gram four times daily in certain cases.
• Pneumonia
- 500mg four times daily
• Urinary tract infections
- 500mg three times daily
• Gastro-intestinal infections
- 500-750 mg three to four times daily
• Typhoid fevers
- Acute: 1-2 grams four times daily for 2 weeks
- Carriers: 1-2 grams four times daily for 4 to
12 weeks

• Gonorrhoea
- 2 grams orally with 1 gram of probenecid as
a single dose. A repeated dose may be
necessary in females.
The dosage may be reduced in patients with
severe kidney failure.
Children under 10 years
Children usually take half the adult dose.
If you take more of your medicine than you
should
If you (or somebody else) accidentally takes too
much of your medicine, speak to your doctor or
pharmacist immediately.
If you forget to take your medicine
If you forget to take a dose, take it as soon as
you remember, then carry on as before. Do not
take a double dose to make up for the dose you
have missed.
If you stop taking your medicine
Keep taking your medicine until your doctor tells
you to stop. Do not stop taking it just because
you feel better. If you stop taking the medicine,
your infection may return or get worse. If you are
still unwell after taking all the medicine, go and
see your doctor.

4.

POSSIBLE SIDE EFFECTS

Like all medicines, ampicillin can cause side
effects, although not everybody gets them. If
they occur, they are likely to be temporary, and
not serious. However, some may be serious and
need medical attention.
If you experience any of the following events
STOP taking your medicine and tell your
doctor or go to your nearest hospital
immediately:
• Hypersensitivity or severe allergic reaction
called anaphylaxis, which causes difficulty
breathing
• Swelling of the lips, cheeks, tongue and
eyelids
• Skin rash, itching or any other skin trouble,
such as blisters and swollen red patches or
hives. These reactions may occur if you have
glandular fever, cytomegalovirus (CMV)
infection, lymphatic leukaemia or HIV infection
• Yellowing of the whites of the eyes and skin
• Difficulty or discomfort in passing urine, having
blood in the urine or lower back pain (may be
a sign of kidney inflammation)
• Pseudomembranous colitis (severe
diarrhoea which may contain blood or
mucous).
The following symptoms are less serious but
you may wish to discuss them with your
doctor or pharmacist if they last a long time.
Common side effects (i.e. have been reported
in more than 1 in 100 people taking it) include:
• Diarrhoea
• Nausea and vomiting (feeling and being sick).

5.

HOW TO STORE AMPICILLIN ORAL
SUSPENSION

Do not use this medicine after the expiry date
shown on the label.
KEEP THIS MEDICINE OUT OF THE SIGHT
AND REACH OF CHILDREN.
Store in its original container and keep the bottle
tightly closed in order to protect from light and
moisture.
Dry powder: Store below 25°C.
Reconstituted suspension: Store for 7 days at
2°C - 8°C in a refrigerator.
Return any left-over medicine to the pharmacist.
Do not throw away any medicines via
wastewater or household waste. Ask your
pharmacist how to throw away medicines you no
longer use. These measures will help to protect
the environment.

6.

CONTENTS OF THE PACK AND OTHER
INFORMATION

What Ampicillin Oral Suspension contains
Ampicillin Oral Suspension is available in two
strengths containing either 125mg/5ml or
250mg/5ml of the active ingredient ampicillin as
ampicillin trihydrate.
The suspensions also contain colloidal
anhydrous silica, sodium benzoate (E211),
croscarmellose sodium, sodium citrate
anhydrous, ponceau 4R (E124), cherry flavour
and sucrose. Please see further information on
ingredients in section 2.
What Ampicillin Oral Suspension looks like
and contents of the pack
Dry powder: an off white granular powder with a
characteristic odour of cherry.
Reconstituted suspension: a light pink coloured
suspension with a characteristic odour of cherry.
The 125mg strength medicine is available in
bottles containing 60ml or 100ml of oral
suspension while the 250mg strength medicine is
available only in packs containing 100ml of oral
suspension.
The licence holder and manufacturer
Athlone Laboratories Limited,
Ballymurray,
Co. Roscommon,
Ireland.
Telephone: 00 353 (0) 90 666 1109
Fax: 00 353 (0) 90 666 1921
Distributed by:
Kent Pharmaceuticals Limited,
Repton Road,
Measham,
DE12 7DT, U.K.
Ampicillin 125mg/5ml Oral Suspension
PL 06453/0004
Ampicillin 250mg/5ml Oral Suspension
PL 06453/0005
This leaflet was last revised April 2014.

Very rare side effects (i.e. have been reported
in less than 1 in 10,000 people) include:
• Fever
• Joint and muscle pain
• Temporary blood disorders that could cause
you to have more infections such as fever,
severe chills, sore throat, mouth ulcers or
bruising more easily. It can also cause
anaemia, this can make your skin pale, cause
weakness, breathlessness and tiredness.
Reporting of side effects
If you get any side effects, talk to your doctor or
pharmacist. This includes any possible side
effects not listed in this leaflet. You can also
report side effects directly via the yellow card
scheme at www.mhra.gov.uk/yellowcard. By
reporting side effects you can help provide more
information on the safety of this medicine.
CP.AMP.JNT.Su.AT.V2P3
Co 97

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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