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ADRENALINE INJECTION BP 1:1000
Active substance(s): ADRENALINE ACID TARTRATE
Adrenaline (Epinephrine) Injection BP 1:1000
Because of your condition it may not be possible for
you to read this leaflet before you are given Adrenaline
(Epinephrine) Injection BP 1:1000.
The leaflet will be kept for you as you may wish to read it
• If you have further questions, please ask your doctor or
• If any of the side effects become serious, or if you notice
any side effects not listed in this leaflet, please tell your
doctor or nurse
In this leaflet:
Pregnancy & breast-feeding
If you are pregnant or are breast-feeding, your doctor will
advise you whether you can be given Adrenaline (Epinephrine)
Injection BP 1:1000 as an emergency treatment.
Effects on the ability to drive and use machines
Using Adrenaline (Epinephrine) Injection BP 1:1000 will not
affect your ability to drive or operate machinery.
Important information about some of the ingredients in
The product also contains Sodium Metabisulphite which may
cause allergic (hypersensitive) type reactions in some people,
which can lead to breathing difficulties or collapse. People
with a history of asthma or allergies (hypersensitivity) are most
likely to experience these problems.
1. What Adrenaline (Epinephrine) Injection BP 1:1000 is and
what it is used for
2. Before Adrenaline (Epinephrine) Injection BP 1:1000 is
3. How Adrenaline (Epinephrine) Injection BP 1:1000 will be
4. Possible side effects.
5. Storing Adrenaline (Epinephrine) Injection BP 1:1000.
6. Further information.
3. How Adrenaline (Epinephrine) Injection BP
1:1000 is given
1. What Adrenaline (Epinephrine) Injection BP
1:1000 is and what it is used for
Your doctor will decide the correct amount for you and when
the injection should be given.
Adrenaline (Epinephrine) belongs to a group of medicines
used for the treatment of serious shock produced by a severe
allergic (hypersensitive) reaction or collapse.
2. Before Adrenaline (Epinephrine) Injection
BP 1:1000 is given
You should not be given Adrenaline (Epinephrine)
Injection BP 1:1000 if you are:
• allergic (hypersensitive) to any of the ingredients in this
• suffering from any form of heart disease.
• in shock (other than that caused by a sudden life
• suffering from brain damage or hardening of the arteries in
• suffering from glaucoma (increased pressure in the eye).
• having or are about to have an operation under general
• in the second stage of labour.
Take special care with Adrenaline (Epinephrine) Injection
BP 1:1000 if you are:
• suffering from high blood pressure.
• pregnant or breastfeeding.
If any of the above apply to you or your child please tell your
doctor before you are given this medicine.
Taking other medicines
Please tell your doctor or nurse if you are taking or have
recently taken any other medicines, including medicines
obtained without a prescription.
Medicines that may interact with Adrenaline (Epinephrine)
Injection BP 1:1000 include:
• antihistamines (drugs used to treat allergic reactions or
• drugs to treat high blood pressure, heart conditions,
depression or thyroid problems.
• ergot alkaloids (drugs used to treat migraine).
• insulin oral hypoglycaemics (drugs used to treat diabetes).
• oxytocin (used in childbirth to stimulate contractions of the
• doxapram (given as an injection in hospitals to help severe
• entacapone (for the treatment of Parkinson’s disease).
• antipsychotics (for the treatment of serious mental
Your doctor will give Adrenaline (Epinephrine) Injection BP
1:1000 to you into a muscle (Intramuscular - IM), though not
usually the buttock, fingers and toes. Your doctor may give you
a diluted injection into your vein (intravenous - IV). If repeated
injections are required your doctor will change the site of
The usual dose is 0.5ml.
There are no specific dose regimens for adrenaline injection
in elderly patients, however adrenaline should be used with
In patients with Parkinson’s disease Adrenaline (Epinephrine)
may increase rigidity (stiffness) and tremors (shaking).
After being given this product, you may experience slight pain,
minor bruising/bleeding or some left over liquid in the place
where you have been injected.
Repeated injection may cause tissue damage in the place
where you have been injected. Tissue damage may also occur
in the extremities (fingers and toes), kidneys and liver.
If any of the side effects get serious or you notice any other
effects not mentioned in this leaflet please tell your doctor or
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist or
nurse. This includes any possible side effects not listed in this
leaflet. You can also report side effects directly via the Yellow
Card Scheme Website: http://www.mhra.gov.uk/yellowcard.
By reporting side effects you can help provide more
information on the safety of this medicine.
5. Storing Adrenaline (Epinephrine) Injection
Keep out of the reach and sight of children.
Your doctor, nurse or paramedic will check that the expiry
date on the label has not been passed before administering
Adrenaline (Epinephrine) Injection BP 1:1000 to you. The
expiry date refers to the last day of the month.
Adrenaline (Epinephrine) is sensitive to light; therefore the
Adrenaline (Epinephrine) Injection BP 1:1000 must always be
kept in the original outer carton.
Do not store above 25ºC and do not freeze.
Over 12 years 0.5mg IM (0.5ml 1:1000 solution)
0.3mg IM (0.3ml 1:1000 solution if the child is small or prepubertal)
You should not be given the Adrenaline (Epinephrine)
Injection BP 1:1000 if you notice it has been used or shows
signs of visible damage.
6 - 12 years 0.3mg IM (0.3ml 1:1000 solution)
6. Further Information
6 months - 6 years 0.15mg IM (0.15ml 1:1000 solution)
What Adrenaline (Epinephrine) Injection BP 1:1000
The active ingredient is Adrenaline (Epinephrine) (as acid
tartrate) 1mg per ml.
The other ingredients are Sodium Chloride, Sodium
Metabisulphite and Water for Injections. Dilute Hydrochloric
acid may be added to adjust the acidity.
Under 6 months 0.01mg/Kg IM (0.01ml/Kg 1:1000 solution)
If necessary, these doses may be repeated several times at 5
- 15 minutes intervals according to blood pressure, pulse and
A small volume syringe should be used
If you take more of Adrenaline (Epinephrine) Injection BP
1:1000 than you should
As this medicine will be given to you whilst you are in hospital,
it is unlikely that you will be given too little or too much,
however, tell your doctor or nurse if you have any concerns.
4. Possible side effects
Like all medicines Adrenaline (Epinephrine) Injection BP
1:1000 can cause side effects, although not everybody gets
Adrenaline (Epinephrine) solutions may be associated with
some unwanted effects although these are normally related to
higher strengths of the drug. The unwanted effects include:
• difficulty in breathing.
• high blood sugar levels.
• high blood pressure.
• palpitations (irregular or faster heart beat)
• tremors (shaking)
• coldness of the fingers and toes
• feeling sick (nausea)
• being sick (vomiting)
• subarachnoid haemorrhage (bleeding in the brain which
can cause very severe headaches, stiff neck, fits and loss of
• hemiplegia (paralysis of one side of the body).
What Adrenaline (Epinephrine) Injection BP 1:1000 looks
like and contents of the pack
The Adrenaline (Epinephrine) Injection BP 1:1000 is a clear,
colourless solution supplied in a pack of 10 glass ampoules
each containing 0.5, 1, 2, 5 or 10ml.
Marketing Authorisation Holder and
Romford, RM3 8UG
This leaflet was last approved in: November 2015
Product License Number: PL 01883/6118R
100mm Measurement Verification Bar