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ADALAT 10MG CAPSULES

Active substance(s): NIFEDIPINE

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Patient information leaflet - information for the user
®

Adalat 10mg capsules
(nifedipine)
Read all of this leaflet carefully before you start
taking this medicine because it contains important
information for you.
Keep this leaflet. You may need to read it again.
If you have any further questions, ask your doctor or pharmacist.
This medicine has been prescribed for you only.
Do not pass it on to others. It may harm them, even if their signs of illness
are the same as yours.
If you get any side effects, talk to your doctor or pharmacist. This includes
any possible side effects not listed in this leaflet. See section 4.
The name of your medicine is Adalat 10mg capsules but it will be referred
to as Adalat capsules throughout this leaflet.

What is in this leaflet
1. What Adalat capsules are and what they
are used for
2. What you need to know before you take
Adalat capsules
3. How to take Adalat capsules
4. Possible side effects
5. How to store Adalat capsules
6. Contents of the pack and other information

1. What Adalat capsules are and what they are
used for
Adalat capsules contain nifedipine, which belongs to a group of medicines
called calcium antagonists.
Adalat capsules are used to treat high blood pressure, angina (chest
pain) or a condition called Raynaud’s phenomenon which causes
discolouration (often whitening) of the fingers and toes.
For high blood pressure: Adalat capsules work by relaxing and expanding
the blood vessels. This makes the blood flow more easily and lowers
blood pressure. Lower blood pressure reduces the strain on your heart.
For angina: Adalat capsules work by relaxing and expanding the arteries
supplying the heart. This allows more blood and oxygen to reach the heart
and decreases the strain on it. Your angina attacks will be less severe and
less frequent if there is less strain on the heart.
Adalat capsules can increase the risk of serious heart problems in patients
with high blood pressure or angina. Because of this, Adalat capsules are
only used in these patients if no other treatments are appropriate.
For Raynaud’s phenomenon: Adalat capsules work by relaxing and
expanding the blood vessels in the fingers and toes. This helps ensure a
good blood supply.

2. What you need to know before you take Adalat
capsules
Do not take Adalat capsules:
If you have had a heart attack within the last month.
If you get a sudden angina attack. Adalat capsules will not help
relieve symptoms of angina quickly.
If you have unstable angina.
If you are allergic to nifedipine, any other similar medicines (known
as dihydropyridines) or any of the other ingredients of this medicine
(listed in section 6).
If you are taking rifampicin, an antibiotic.
If you have been told that you have a narrowing of the aortic
heart valve (stenosis).
If you have ever had a collapse caused by a heart problem
(cardiogenic shock), during which you became breathless, pale and
had a cold sweat and dry mouth.
If your blood pressure continues to rise despite treatment
(malignant hypertension).
 Tell your doctor and do not take Adalat capsules if any of these
apply to you.

Warnings and precautions
Talk to your doctor before taking Adalat capsules.
If you have low blood pressure. Your blood pressure may be
decreased further by this treatment.
If you have a heart condition where your heart cannot cope with
increased strain (poor cardiac reserve).
If you are pregnant.
If you are breast-feeding.
If you are a diabetic. The treatment for your diabetes may need to be
adjusted. If you have any questions about this, ask your doctor.

If you are on kidney dialysis. If you have a very high blood pressure
and a low blood volume, you might experience a sudden drop in blood
pressure when you take Adalat capsules.
If your liver is not working properly. Your doctor may need to do
some blood tests. You may also be given a lower dose of Adalat
capsules.
 Talk to your doctor before you take Adalat capsules if any of
these apply to you.

Tell your doctor:
If your chest pain (angina) gets worse (comes on more often or
more severely) over a matter of hours or days. You may be advised
not to take Adalat capsules.
If you have chest pains after taking your first dose of Adalat
capsules. Your doctor may wish to change your treatment.
If you notice increased breathlessness.
If you notice swelling of the ankles.
 Tell your doctor before you take the next dose if any of these apply
to you.

Also tell your doctor:
If you are giving a urine sample. Adalat capsules may interfere with
the results of certain urine tests.
If you are a man who has been unable to father a child by in vitro
fertilisation. Drugs like Adalat capsules have been shown to impair
sperm function.

Other medicines and Adalat capsules
Tell your doctor if you are taking, have recently taken or might take any
other medicines.
Some medicines may affect the way Adalat capsules work. Tell your
doctor if you are taking:
Other medicines to treat high blood pressure.
Rifampicin (an antibiotic).
Cimetidine (to treat stomach ulcers).
Digoxin, diltiazem, quinidine or beta-blockers (to treat heart
conditions).
Quinupristin/dalfopristin (a combination antibiotic).
Phenytoin, carbamazepine or valproic acid (to treat epilepsy).
Cisapride (to treat reduced movements of the gullet and stomach).
Magnesium sulphate injections during pregnancy (may cause a
severe fall in blood pressure).
Erythromycin (an antibiotic).
Ketoconazole, itraconazole or fluconazole (anti-fungal medicines).
Indinavir, nelfinavir, ritonavir, saquinavir or amprenavir (to treat
HIV).
Fluoxetine or nefazodone (to treat depression).
Tacrolimus (to prevent the rejection of transplanted organs).
Phenobarbital (usually used to treat insomnia or anxiety).

Adalat capsules with food and drink
You can take Adalat capsules either with or without food.
Do not drink grapefruit juice or eat grapefruit while taking Adalat
capsules.
Do not start taking Adalat capsules within 3 days of drinking grapefruit
juice or eating grapefruit. Tell your doctor if you have had grapefruit or
grapefruit juice in this time. Also, do not drink grapefruit juice or eat
grapefruit whilst taking Adalat capsules. Grapefruit juice is known to
increase the blood levels of the active ingredient, nifedipine. This effect
can last for at least 3 days.

Pregnancy and breast-feeding
If you are pregnant, think you may be pregnant or are planning to have a
baby, ask your doctor for advice before taking this medicine.
You may be able to use Adalat capsules, but only after special
consideration and agreement by your doctor.
Do not take Adalat capsules if you are breast-feeding. If you need to
take Adalat capsules while breast-feeding, tell your doctor before taking
this medicine.

Driving and using machines
Adalat capsules may make you feel dizzy, faint, extremely tired or have
visual disturbances. Do not drive or operate machinery if you are affected
in this way.
This may be more likely when you first start treatment, if you change
tablets, or if you have drunk alcohol.
Adalat capsules contain Yellow orange S (E110)
May cause allergic reactions.

3. How to take Adalat capsules
Always take this medicine exactly as your doctor has told you. Check with
your doctor if you are not sure.

To start with, you may be given a lower strength (5mg) capsule every
8 hours. This allows your doctor to monitor how you are responding so
that the best long-term dose can be identified.
The dose can be increased to a maximum of 20mg every 8 hours.
Lower doses may be prescribed for older patients or for patients
who have liver problems.
Swallow the capsules whole with a little water.
Continue to take the capsules for as long as your doctor has told
you to.
Do not take them with grapefruit juice.
You can take Adalat capsules either with or without food.
Use in children and adolescents: Adalat capsules are not
recommended for use in children and adolescents below 18 years of age,
because there are only limited data on the safety and efficacy in this
population.

If you take more Adalat capsules than you should

feeling sick (nausea)
muscle cramps
joint swelling
sleep disorders
anxiety or nervousness
reddening of the skin
nose bleeds
nasal congestion
sensation of spinning or whirling motion (vertigo)
migraine
dizziness
trembling
increase in the need to pass water (urinate)
painful or difficult urination
inability to achieve or maintain an erection (impotence)
blurred vision
temporary increase in certain liver enzymes

 Get medical help immediately. If possible, take your capsules or the
box with you to show the doctor.

Rare side effects

Taking too many capsules may cause your blood pressure to become too
low and your heart beats to speed up or slow down. It may also lead to an
increase in your blood sugar level or an increase in the acidity of your
blood, swelling in the lungs, low blood oxygen levels and disturbances in
consciousness, possibly leading to unconsciousness.

Other side effects

If you forget to take Adalat capsules
Take your normal dose immediately and continue taking your capsules as
prescribed, waiting 8 hours before taking your next dose.
Do not take a double dose to make up for a forgotten dose.
If you have any further questions on the use of this medicine, ask your
doctor.

4. Possible side effects
Like all medicines, this medicine can cause side effects, although not
everybody gets them.

Serious side effects
If you notice:
severe, sudden generalised allergic reaction including very rarely
life- threatening shock (e.g. difficulty in breathing, drop of blood
pressure, fast pulse) or swelling (including potentially life-threatening
swelling of the airway)
other allergic reactions causing swelling under the skin (possibly
severe and including swelling of the larynx that may result in a
life- threatening outcome)
fast heart beat (tachycardia)
shortness of breath or difficulty breathing
mild to moderate allergic reactions
itching (possibly severe), a rash or hives
 Contact your doctor immediately and do not take the next dose
as these may be the first signs of allergic reaction which may become
severe.

(These may affect up to 1 in 1,000 people)
pins and needles
inflammation of the gums, tender or swollen gums, bleeding gums
(Frequency not known: frequency cannot be estimated from the available
data)
vomiting
a reduction in the number of white blood cells (leucopenia)
a more severe decrease in a specific class of white blood cell
(agranulocytosis)
increased blood sugar (hyperglycaemia)
decreased skin sensitivity (hypoaesthesia)
drowsiness (somnolence)
eye pain
chest pain (angina pectoris)
heartburn or indigestion (gastroesophageal sphincter insufficiency)
yellowing of the whites of the eyes or skin (jaundice)
sensitivity to light (photosensitivity allergic reaction)
small, raised areas of bleeding in the skin (palpable purpura)
joint pain
muscle pain
All of these symptoms usually go away when treatment with Adalat
capsules is stopped.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This
includes any possible side effects not listed in this leaflet. You can also
report side effects directly via the Yellow Card Scheme at:
www.mhra.gov.uk/yellowcard
By reporting side effects, you can help provide more information on the
safety of this medicine.

5. How to store Adalat capsules

Apart from the side effects listed above, these are the other side effects of
Adalat capsules, starting with the more common ones:

Keep out of the sight and reach of children.
Do not take your capsules after the expiry date which is stated on the
carton/blister label after ‘Exp’. The expiry date refers to the last day of that
month.
Do not store above 25ºC.
Store in the original package in order to protect from light.
If your capsules become discoloured or show any signs of deterioration,
you should seek the advice of your pharmacist.
The capsules should not be disposed of via wastewater or household
waste. If they are out of date, or no longer suitable for you, return them to
your pharmacist.

Common side effects

6. Further information

If you develop:
a skin reaction or blistering/peeling of the skin and/or mucosal
reactions (in the mouth/nose or at the penis/vagina) (Toxic Epidermal
Necrolysis)
 Contact your doctor immediately before you continue treatment
as these may be signs of a severe reaction.

Less serious side effects

(These may affect up to 1 in 10 people)
headache
flushing
general feeling of being unwell
constipation
swelling, particularly of the ankles and legs

Uncommon side effects
(These may affect up to 1 in 100 people)
stomach pain (abdominal pain)
unspecific pain
chills
low blood pressure when standing up (symptoms include fainting,
dizziness, light headedness, occasional palpitations, blurred vision
and sometimes confusion)
fainting
irregular heart beat (palpitations)
dry mouth
indigestion or upset stomach
wind (flatulence)

What Adalat capsules contain
Adalat capsules contain the active ingredient nifedipine.
Each capsule contains 10mg nifedipine.
Other ingredients are gelatin, glycerol, polyethylene glycol 400,
peppermint oil, purified water, saccharin sodium, sunset yellow FCF
(E110) and titanium dioxide (E171).

What Adalat capsules look like and content of the pack
Adalat capsules are orange, oblong, soft gel capsules containing a yellow
viscous fluid.
Adalat capsules come in blister packs containing 50 capsules.
Manufactured by: Meda Manufacturing GmbH, Cologne, Germany.
Procured from within the EU and repackaged by the Product Licence
holder: B&S Healthcare, Unit 4, Bradfield Road, Ruislip, Middlesex,
HA4 0NU, UK.
POM
Adalat® 10mg capsules,
PL No: 18799/2402
Leaflet date: 16.11.2015
Adalat is a registered trademark of Bayer.

Patient information leaflet - information for the user

Nifedipine 10mg capsules
Read all of this leaflet carefully before you start
taking this medicine because it contains important
information for you.
Keep this leaflet. You may need to read it again.
If you have any further questions, ask your doctor or pharmacist.
This medicine has been prescribed for you only.
Do not pass it on to others. It may harm them, even if their signs of illness
are the same as yours.
If you get any side effects, talk to your doctor or pharmacist. This includes
any possible side effects not listed in this leaflet. See section 4.
The name of your medicine is Nifedipine 10mg capsules but it will be
referred to as Nifedipine capsules throughout this leaflet.

What is in this leaflet
1. What Nifedipine capsules are and what
they are used for
2. What you need to know before you take
Nifedipine capsules
3. How to take Nifedipine capsules
4. Possible side effects
5. How to store Nifedipine capsules
6. Contents of the pack and other information

If you are a diabetic. The treatment for your diabetes may need to be
adjusted. If you have any questions about this, ask your doctor.
If you are on kidney dialysis. If you have a very high blood pressure
and a low blood volume, you might experience a sudden drop in blood
pressure when you take Nifedipine capsules.
If your liver is not working properly. Your doctor may need to do
some blood tests. You may also be given a lower dose of Nifedipine
capsules.
 Talk to your doctor before you take Nifedipine capsules if any of
these apply to you.

Tell your doctor:
If your chest pain (angina) gets worse (comes on more often or
more severely) over a matter of hours or days. You may be advised
not to take Nifedipine capsules.
If you have chest pains after taking your first dose of Nifedipine
capsules. Your doctor may wish to change your treatment.
If you notice increased breathlessness.
If you notice swelling of the ankles.
 Tell your doctor before you take the next dose if any of these apply
to you.

Also tell your doctor:
If you are giving a urine sample. Nifedipine capsules may interfere
with the results of certain urine tests.
If you are a man who has been unable to father a child by in vitro
fertilisation. Drugs like Nifedipine capsules have been shown to impair
sperm function.

Other medicines and Nifedipine capsules

1. What Nifedipine capsules are and what they are
used for
Nifedipine capsules contain nifedipine, which belongs to a group of
medicines called calcium antagonists.
Nifedipine capsules are used to treat high blood pressure, angina
(chest pain) or a condition called Raynaud’s phenomenon which
causes discolouration (often whitening) of the fingers and toes.
For high blood pressure: Nifedipine capsules work by relaxing and
expanding the blood vessels. This makes the blood flow more easily and
lowers blood pressure. Lower blood pressure reduces the strain on your
heart.
For angina: Nifedipine capsules work by relaxing and expanding the
arteries supplying the heart. This allows more blood and oxygen to reach
the heart and decreases the strain on it. Your angina attacks will be less
severe and less frequent if there is less strain on the heart.
Nifedipine capsules can increase the risk of serious heart problems in
patients with high blood pressure or angina. Because of this, Nifedipine
capsules are only used in these patients if no other treatments are
appropriate.
For Raynaud’s phenomenon: Nifedipine capsules work by relaxing and
expanding the blood vessels in the fingers and toes. This helps ensure a
good blood supply.

2. What you need to know before you take
Nifedipine capsules
Do not take Nifedipine capsules:
If you have had a heart attack within the last month.
If you get a sudden angina attack. Nifedipine capsules will not help
relieve symptoms of angina quickly.
If you have unstable angina.
If you are allergic to nifedipine, any other similar medicines (known
as dihydropyridines) or any of the other ingredients of this medicine
(listed in section 6).
If you are taking rifampicin, an antibiotic.
If you have been told that you have a narrowing of the aortic
heart valve (stenosis).
If you have ever had a collapse caused by a heart problem
(cardiogenic shock), during which you became breathless, pale and
had a cold sweat and dry mouth.
If your blood pressure continues to rise despite treatment
(malignant hypertension).
 Tell your doctor and do not take Nifedipine capsules if any of
these apply to you.

Warnings and precautions
Talk to your doctor before taking Nifedipine capsules.
If you have low blood pressure. Your blood pressure may be
decreased further by this treatment.
If you have a heart condition where your heart cannot cope with
increased strain (poor cardiac reserve).
If you are pregnant.
If you are breast-feeding.

Tell your doctor if you are taking, have recently taken or might take any
other medicines.
Some medicines may affect the way Nifedipine capsules work. Tell your
doctor if you are taking:
Other medicines to treat high blood pressure.
Rifampicin (an antibiotic).
Cimetidine (to treat stomach ulcers).
Digoxin, diltiazem, quinidine or beta-blockers (to treat heart
conditions).
Quinupristin/dalfopristin (a combination antibiotic).
Phenytoin, carbamazepine or valproic acid (to treat epilepsy).
Cisapride (to treat reduced movements of the gullet and stomach).
Magnesium sulphate injections during pregnancy (may cause a
severe fall in blood pressure).
Erythromycin (an antibiotic).
Ketoconazole, itraconazole or fluconazole (anti-fungal medicines).
Indinavir, nelfinavir, ritonavir, saquinavir or amprenavir (to treat
HIV).
Fluoxetine or nefazodone (to treat depression).
Tacrolimus (to prevent the rejection of transplanted organs).
Phenobarbital (usually used to treat insomnia or anxiety).

Nifedipine capsules with food and drink
You can take Nifedipine capsules either with or without food.
Do not drink grapefruit juice or eat grapefruit while taking Nifedipine
capsules.
Do not start taking Nifedipine capsules within 3 days of drinking grapefruit
juice or eating grapefruit. Tell your doctor if you have had grapefruit or
grapefruit juice in this time. Also, do not drink grapefruit juice or eat
grapefruit whilst taking Nifedipine capsules. Grapefruit juice is known to
increase the blood levels of the active ingredient, nifedipine. This effect
can last for at least 3 days.

Pregnancy and breast-feeding
If you are pregnant, think you may be pregnant or are planning to have a
baby, ask your doctor for advice before taking this medicine.
You may be able to use Nifedipine capsules, but only after special
consideration and agreement by your doctor.
Do not take Nifedipine capsules if you are breast-feeding. If you need
to take Nifedipine capsules while breast-feeding, tell your doctor before
taking this medicine.

Driving and using machines
Nifedipine capsules may make you feel dizzy, faint, extremely tired or
have visual disturbances. Do not drive or operate machinery if you are
affected in this way.
This may be more likely when you first start treatment, if you change
tablets, or if you have drunk alcohol.
Nifedipine capsules contain Yellow orange S (E110)
May cause allergic reactions.

3. How to take Nifedipine capsules
Always take this medicine exactly as your doctor has told you. Check with
your doctor if you are not sure.

To start with, you may be given a lower strength (5mg) capsule every
8 hours. This allows your doctor to monitor how you are responding so
that the best long-term dose can be identified.
The dose can be increased to a maximum of 20mg every 8 hours.
Lower doses may be prescribed for older patients or for patients
who have liver problems.
Swallow the capsules whole with a little water.
Continue to take the capsules for as long as your doctor has told
you to.
Do not take them with grapefruit juice.
You can take Nifedipine capsules either with or without food.
Use in children and adolescents: Nifedipine capsules are not
recommended for use in children and adolescents below 18 years of age,
because there are only limited data on the safety and efficacy in this
population.

If you take more Nifedipine capsules than you should

feeling sick (nausea)
muscle cramps
joint swelling
sleep disorders
anxiety or nervousness
reddening of the skin
nose bleeds
nasal congestion
sensation of spinning or whirling motion (vertigo)
migraine
dizziness
trembling
increase in the need to pass water (urinate)
painful or difficult urination
inability to achieve or maintain an erection (impotence)
blurred vision
temporary increase in certain liver enzymes

 Get medical help immediately. If possible, take your capsules or the
box with you to show the doctor.

Rare side effects

Taking too many capsules may cause your blood pressure to become too
low and your heart beats to speed up or slow down. It may also lead to an
increase in your blood sugar level or an increase in the acidity of your
blood, swelling in the lungs, low blood oxygen levels and disturbances in
consciousness, possibly leading to unconsciousness.

Other side effects

If you forget to take Nifedipine capsules
Take your normal dose immediately and continue taking your capsules as
prescribed, waiting 8 hours before taking your next dose.
Do not take a double dose to make up for a forgotten dose.
If you have any further questions on the use of this medicine, ask your
doctor.

4. Possible side effects
Like all medicines, this medicine can cause side effects, although not
everybody gets them.

Serious side effects
If you notice:
severe, sudden generalised allergic reaction including very rarely
life- threatening shock (e.g. difficulty in breathing, drop of blood
pressure, fast pulse) or swelling (including potentially life-threatening
swelling of the airway)
other allergic reactions causing swelling under the skin (possibly
severe and including swelling of the larynx that may result in a
life- threatening outcome)
fast heart beat (tachycardia)
shortness of breath or difficulty breathing
mild to moderate allergic reactions
itching (possibly severe), a rash or hives
 Contact your doctor immediately and do not take the next dose
as these may be the first signs of allergic reaction which may become
severe.
If you develop:
a skin reaction or blistering/peeling of the skin and/or mucosal
reactions (in the mouth/nose or at the penis/vagina) (Toxic Epidermal
Necrolysis)
 Contact your doctor immediately before you continue treatment
as these may be signs of a severe reaction.

Less serious side effects
Apart from the side effects listed above, these are the other side effects of
Nifedipine capsules, starting with the more common ones:

Common side effects
(These may affect up to 1 in 10 people)
headache
flushing
general feeling of being unwell
constipation
swelling, particularly of the ankles and legs

Uncommon side effects
(These may affect up to 1 in 100 people)
stomach pain (abdominal pain)
unspecific pain
chills
low blood pressure when standing up (symptoms include fainting,
dizziness, light headedness, occasional palpitations, blurred vision
and sometimes confusion)
fainting
irregular heart beat (palpitations)
dry mouth
indigestion or upset stomach
wind (flatulence)

(These may affect up to 1 in 1,000 people)
pins and needles
inflammation of the gums, tender or swollen gums, bleeding gums
(Frequency not known: frequency cannot be estimated from the available
data)
vomiting
a reduction in the number of white blood cells (leucopenia)
a more severe decrease in a specific class of white blood cell
(agranulocytosis)
increased blood sugar (hyperglycaemia)
decreased skin sensitivity (hypoaesthesia)
drowsiness (somnolence)
eye pain
chest pain (angina pectoris)
heartburn or indigestion (gastroesophageal sphincter insufficiency)
yellowing of the whites of the eyes or skin (jaundice)
sensitivity to light (photosensitivity allergic reaction)
small, raised areas of bleeding in the skin (palpable purpura)
joint pain
muscle pain
All of these symptoms usually go away when treatment with Nifedipine
capsules is stopped.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This
includes any possible side effects not listed in this leaflet. You can also
report side effects directly via the Yellow Card Scheme at:
www.mhra.gov.uk/yellowcard
By reporting side effects, you can help provide more information on the
safety of this medicine.

5. How to store Nifedipine capsules
Keep out of the sight and reach of children.
Do not take your capsules after the expiry date which is stated on the
carton/blister label after ‘Exp’. The expiry date refers to the last day of that
month.
Do not store above 25ºC.
Store in the original package in order to protect from light.
If your capsules become discoloured or show any signs of deterioration,
you should seek the advice of your pharmacist.
The capsules should not be disposed of via wastewater or household
waste. If they are out of date, or no longer suitable for you, return them to
your pharmacist.

6. Contents of the pack and other information
What Nifedipine capsules contain
Nifedipine capsules contain the active ingredient nifedipine.
Each capsule contains 10mg nifedipine.
Other ingredients are gelatin, glycerol, polyethylene glycol 400,
peppermint oil, purified water, saccharin sodium, sunset yellow FCF
(E110) and titanium dioxide (E171).

What Nifedipine capsules look like and content of the pack
Nifedipine capsules are orange, oblong, soft gel capsules containing a
yellow viscous fluid.
Nifedipine capsules come in blister packs containing 50 capsules.
Manufactured by: Meda Manufacturing GmbH, Cologne, Germany.
Procured from within the EU and repackaged by the Product Licence
holder: B&S Healthcare, Unit 4, Bradfield Road, Ruislip, Middlesex,
HA4 0NU, UK.
POM
Nifedipine 10mg capsules
PL 18799/2402
Leaflet date: 16.11.2015

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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