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Active substance(s): NEFOPAM HYDROCHLORIDE

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Acupan® 30mg Tablets
(nefopam hydrochloride)
Patient Information Leaflet
Read all of this leaflet carefully before you start taking this medicine
because it contains important information for you.
− Keep this leaflet. You may need to read it again
− If you have any further questions, ask your doctor or pharmacist.
− This medicine has been prescribed for you only. Do not pass it on to
others. It may harm them, even if their signs of illness are the same as
− If you get any side effects, talk to your doctor or pharmacist. This
includes any possible side effects not listed in this leaflet. See section 4.
In this leaflet:
1) What Acupan is and what it is used for
2) What you need to know before you take Acupan
3) How to take Acupan
4) Possible side effects
5) How to store Acupan
6) Contents of the pack and other information

1) What Acupan is and what it is used for
The name of your medicine is Acupan 30mg Tablets (referred to as Acupan
throughout this leaflet).
Acupan belongs to a group of medicines called analgesics, commonly known
as pain killers or pain relievers. The active substance, nefopam hydrochloride,
interrupts the pain messages being sent to your brain, and it also acts in your
brain to stop pain messages being felt. This means that Acupan does not stop
the pain from happening, but you will not be able to feel the pain as much.
Acupan is used to relieve of acute and chronic pain (for example pain after an
operation, dental pain, joint or muscle pain, after an injury, or pain caused by
cancer). Acupan should not be used to treat the pain from a heart attack.

2) What you need to know before you take Acupan
Do not take Acupan if:
• you are a child under 12 years old
• you have ever had an allergic reaction to nefopam hydrochloride or any of
the ingredients resulting in a skin rash, swelling of the face or difficulty in
breathing (see section 6. Contents of the pack and other information)
• you are taking monoamine oxidase inhibitors (MAOIs) to treat your
• you have, or have ever had, epilepsy (fits).
Take special care with Acupan
If the answer to any of the following is ‘yes’, you must tell your doctor –
your doctor may decide to alter your treatment.
− Are you pregnant or breast feeding?

Do you have severe problems with your liver or kidneys?
Do you have, or have you had in the past difficulty passing urine?
Are you taking other medicines?
Have you previously been diagnosed with glaucoma (increased pressure in
the eye)?

Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently
taken any other medicines, including those obtained without prescription and
medicines listed below:
• Monoamine oxidase inhibitors (known as MAOIs) for depression. You must
tell your doctor if you are taking this medicine.
• Tricyclic antidepressants for depression
• Anticholinergics
• Sympathomimetics
Tell your doctor or dentist if you are taking any of these medicines.
Pregnancy and breast-feeding
Acupan should not be taken during pregnancy or while breast-feeding.
Ask your doctor or pharmacist for advice before taking any medicine. Please
contact your doctor if you become pregnant during your treatment.
Driving and using machines
Acupan can cause drowsiness. Do not drive or operate heavy machinery
unless you know how Acupan affects you.

3) How to take Acupan
Dosage for adults:
Always take Acupan exactly as your doctor has told you.
The usual initial dose is two tablets taken three times a day. Your doctor may
increase this dose up to a maximum of three tablets taken three times a day
according to your needs.
Ask your doctor or pharmacist if:
• you are not sure how many tablets to take or when to take them
• you think the effect is too strong or too weak
Swallow your tablets with water.
Dosage for children:
Over 12 years - as per adults (see above).
Under 12 years - Acupan 30mg Tablets should not be taken by children
under 12.
Dosage for older patients:
In older patients the doctor may reduce the number of tablets that are taken.
Dosage for patients with kidney and/or liver problems:
Your doctor may adjust the dose of Acupan depending upon your condition.

If you take more Acupan than you should
If you accidentally take more tablets than your prescribed dose, tell your
doctor or pharmacist immediately and if necessary contact your nearest
hospital casualty department. Remember to take the pack and any remaining
medicines with you.

By reporting side effects you can help provide more information on the safety
of this medicine.

5) How to store Acupan

If you stop taking Acupan
Do not stop taking Acupan without first checking with your doctor.
If you have any further questions on the use of this product, ask your doctor
or pharmacist.

• Do not use after the expiry date printed on the carton label or blister strip.
• Do not store above 30ºC. Protect from light. Store in the original package
• If your doctor tells you to stop taking the tablets, please take them back to
the pharmacist for safe disposal. Only keep the tablets if your doctor tells
you to.
• If the tablets become discoloured or show any other signs of deterioration,
you should seek the advice of your pharmacist who will tell you what to do.

4) Possible side effects

6) Contents of the pack and other information

If you forget to take Acupan
If you forget to take Acupan, take it as soon as you remember. Do not take
more than one dose at the same time to make up for the forgotten dose.

Like all medicines Acupan can cause side effects, although not everybody
gets them.

What Acupan contains
Each tablet contains 30mg nefopam hydrochloride.

Please stop taking this medicine and contact your doctor as soon as
possible if you experience the following rare reactions:
• swelling of the skin and soft tissue around the eyes, nose and throat
(angioedema), or allergic reactions (anaphylaxis).

The tablets also contain the following inactive ingredients: Calcium phosphate
dibasic dihydrate, microcrystalline cellulose, maize starch, magnesium
stearate,hydrogenated vegetable oil, colloidal silicon dioxide, hypromellose
2910 (15cps), titanium dioxide.

Side-effects which may occur most frequently include:
• feeling sick
• feeling light-headed, dizzy or nervous, or fainting
• a decrease in blood pressure
• numbness or tingling in the extremities
• a dry mouth
• having difficulty passing urine
• convulsions, tremor
• confusion
• hallucinations (seeing things that aren’t there).

What Acupan looks like and contents of the pack
The tablets are round, white and marked 'APN' on one side and plain on the

Other side-effects which may occur less frequently include:
• being sick
• abdominal pain or diarrhoea
• blurred vision
• drowsiness
• sweating
• trouble sleeping
• headaches
• awareness of your heartbeat (palpitations), or a
• coma

Each pack contains 30 tablets.
PL 10383/1752

Acupan 30mg Tablets


Who makes and repackages your medicine:
Your medicine is manufactured by 3M Health Care Ltd, 3M House, 1 Morley
Street, Loughborough, Leicestershire, LE11 1EP, UK. Procured from within
the EU and repackaged by the Product Licence Holder: Primecrown Ltd., 4/5
Northolt Trading Estate, Belvue Road, Northolt, Middlesex, UB5 5QS.
Leaflet date: 25.07.2017
Acupan is a registered trademark of Meda AB, Sweden.



Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This
includes any possible side effects not listed in this leaflet. You can also report
side effects directly via Yellow Card Scheme

Blind or partially sighted?
Is this leaflet hard to see or read?
Call 020 8839 3000 to obtain the
leaflet in a format suitable for you.

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Further information

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