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ACETAZOLAMIDE TABLETS BP 250MG

Active substance(s): ACETAZOLAMIDE

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PATIENT INFORMATION LEAFLET

ACETAZOLAMIDE

Tablets 250mg
Please read all of this leaflet carefully before you start taking this medicine.
Keep the leaflet; you may need to read it again. If you have any questions
or are not sure about anything, ask your doctor or pharmacist.
This medicine has been prescribed for you. Do not pass it on to others.
It may harm them, even if their symptoms are the same as yours. If any of
the side effects gets serious, or if you notice any side effects not
listed in this leaflet tell your doctor or pharmacist.
In this leaflet:
1. What Acetazolamide Tablets are and what they are used for
2. Before you take Acetazolamide Tablets
3. How to take Acetazolamide Tablets
4. Possible side effects
5. How to store Acetazolamide Tablets
6. Further information

1. What Acetazolamide Tablets are and what they are used for
These tablets contain the active ingredient Acetazolamide, which is one of the group of
medicines called carbonic anhydrase inhibitors.
These are used in the treatment of abnormal retention of fluids and epilepsy.
They are also used to treat chronic simple glaucoma, secondary glaucoma and before an
operation in acute angle closure glaucoma.

2. Before you take Acetazolamide Tablets
Do not take these tablets if:
• you are allergic to Acetazolamide, sulphonamides or any of the ingredients in the tablets
• you have low blood levels of sodium or potassium
• you have kidney disease or kidney problems
• you have liver disease including cirrhosis, or liver problems
• you have an underactive adrenal gland
• you have hyperchloremic acidosis (high levels of chloride in the blood).
Do not take these tablets for a long term if:
• you suffer from chronic congestive angle-closure glaucoma.
Check with your doctor before taking these tablets if:
• you have lung problems such as bronchitis, asthma, wheezing or emphysema
• you have a history of kidney stones as this medicine may cause further kidney stones
• you are pregnant, think you may be pregnant or are breast-feeding.
Taking other medicines:
Check with your doctor or pharmacist before taking these tablets if you are taking other
medicines, including any that you can buy without a prescription.
This is particularly important if you are taking:
• medicines used for heart problems, e.g. digoxin
• medicines used to control high blood pressure
• medicines to treat blood clotting such as warfarin
• medicines to lower blood sugar levels
• folic acid antagonists such as methotrexate
• aspirin
• phenytoin, carbamazepine, primidone (for epilepsy)
• ciclosporin used to prevent organ rejection following a transplant
• lithium used to treat mental illness
• methanamine used to treat urinary tract infections
• medicines containing sodium bicarbonate.
Other special warnings:
If you are taking this medicine for a long time your doctor may want to do some tests to
check your blood cell count and electrolyte levels.
Some medicines used for treating epilepsy have been reported to cause some people to think
about harming themselves; you must tell your doctor if you start to have any thoughts about
harming yourself whilst you are taking this medicine.
Driving and using machinery:
This medicine may cause drowsiness, dizziness and confusion and may affect your
eyesight. Do not drive or operate machinery if this medicine has this effect on you.

3. How to take Acetazolamide Tablets
The tablets should be swallowed with a drink of water.
Your doctor will decide the dose that is best for you. The pharmacist’s label will also tell
you how many tablets to take and how often. If you are not sure about anything, ask your
doctor or pharmacist.
Adults
Glaucoma and epilepsy: 1 - 4 tablets daily in divided doses.
Abnormal retention of fluids (for example in heart failure): 1-1½ tablets daily,
in the morning for 2 days, rest a day and then repeat, or every other day.
In premenstrual tension: Half to 1½ tablets daily.
P0272T

Measure bar should be 150mm at 100% scale

Warning! We cannot accept responsibility for any errors
in this proof after approval. Whilst we take extreme care
at all times to ensure accuracy to our clientʼs brief,
the final responsibility must be taken by our client.
IF YOU SIGN THIS PROOF YOU ARE SIGNIFYING
FULL APPROVAL OF DESIGN AND TEXT.

Customer

Crescent Pharma

Colours Used

Description

Acetazolamide 250mg Leaflet

Process Black

Item Code

P0272T

Profile

N/A

Size

148 x 315mm

Min. Point Size

8.5pt (Body) 6.25pt (Item code)

Market

UK

Language

English

Proof By

neil.everitt

Proof No.

7

Date

09/09/2014

Artwork No.

532079

Keyline - does not print

Pharma
Code

72

Children
Epilepsy: 8 to 30mg/kg body weight daily in divided doses.
The maximum daily dose is 750mg.
Elderly: Caution should be exercised in older patients.
If you forget to take a dose: take your dose as soon as you remember and then
your next dose at the usual time. However, if it is almost time for your next dose, skip
the missed dose and continue with your normal dosing schedule.
DO NOT DOUBLE THE DOSES.
If you have taken too many tablets:
Contact your doctor straight away or go to the nearest hospital casualty department.
Take with you any remaining tablets and the pack so that the medicine can be identified.

4. Possible side effects
Like all medicines, acetazolamide can cause side effects, although not everybody gets them.
If any of the following occur STOP TAKING the tablets IMMEDIATELY and
contact your doctor:
• Difficulty breathing or dizziness; a rash, itching or hives (raised red weals) on the skin;
or sudden swelling of the face, throat or lips. These are signs of a serious
allergic reaction
• Other serious skin reactions including blistering, swelling, or Stevens-Johnson
syndrome (symptoms are blisters on the skin, eyes, mouth and genitals).
Tell your doctor or pharmacist if you notice any of the following effects:
• Yellowing of the skin or whites of the eyes, pale or dark tarry stools, dark urine, loss of appetite,
confusion, feeling sick, itching, fever, trembling, weight loss. These may be symptoms of liver
problems or failure, liver disease, or a type of jaundice due to bile in the blood
• Light-headedness, muscle twitching or cramps, feeling or being sick, rapid breathing,
confusion or tiredness. These may be symptoms of changes in your body’s electrolyte levels
or metabolic acidosis (a condition where your blood contains too much acid) and may occur
following a long course of this medicine.
The following side effects have also been reported:
• Passing large volumes of urine
• Excessive thirst, loss of appetite, taste disturbances, feeling or being sick, diarrhoea
• Tingling, numbness or burning sensation in the hands and feet
• Flushing, headache, dizziness, tiredness, irritability, depression
• Short-sightedness which lasts only a short time and which usually subsides when
the medicine is withdrawn or the dose reduced
• Severe lower back or groin pain caused by stones in the kidney or ureter (the tube
through which urine passes), or crystals in the urine or kidney tissue damage
• Decreased sex drive.
Uncommon effects (that may happen to less than 1 in 100 people):
• Blood disorders which may cause symptoms such as fever, tiredness, bruising and
sometimes abnormal bleeding or makes infections more likely
• Black tarry stools, blood or excess sugar in the urine
• Kidney failure (symptoms include difficulty in passing urine or no urine output)
• Paralysis with loss of muscle tone
• Convulsions (fits)
• Drowsiness, confusion, fever
• Ringing in the ears or difficulty in hearing.
Rare effects (that may happen to less than 1 in 1000 people):
• Increased skin sensitivity to sunlight.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible
side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card
Scheme at: www.mhra.gov.uk/yellowcard. By reporting side effects you can help provide more
information on the safety of this medicine.

5. How to store Acetazolamide Tablets
Keep the tablets in the pack provided and protect from heat, light and moisture.
KEEP ALL MEDICINES OUT OF THE SIGHT AND REACH OF CHILDREN
Do not take the tablets if the expiry date on the pack has passed. If you have any
medicines that are out of date, return them to your pharmacist for safe disposal.

6. Further information
Ingredients:
Acetazolamide Tablets 250mg contain 250mg of Acetazolamide as the active ingredient.
Other ingredients are: dicalcium phosphate, maize starch, pregelatinised maize starch,
sodium starch glycolate and magnesium stearate.
What the medicine looks like:
Acetazolamide Tablets are white, round tablets engraved with R and crescent moon logo on
one side and A303 on the other. They are supplied to your pharmacist in packs containing
28, 30, 42, 50, 56, 60, 84, 90, 100, 112, 250, 500 and 1000 tablets. Not all pack sizes may be
available.
Who makes this medicine and holds the product licence:
The Product Licence Holder is Crescent Pharma Limited, Units 3 & 4, Quidhampton Business
Units, Polhampton Lane, Overton, Hants, RG25 3ED and the Manufacturer is
Surepharm Services Ltd., Bretby, Burton upon Trent, Staffs, DE15 OYZ, UK.
Date leaflet revised: August 2014
If you would like this leaflet in a different format please contact the licence holder at
the above address.
P0272T

Measure bar should be 150mm at 100% scale

Warning! We cannot accept responsibility for any errors
in this proof after approval. Whilst we take extreme care
at all times to ensure accuracy to our clientʼs brief,
the final responsibility must be taken by our client.
IF YOU SIGN THIS PROOF YOU ARE SIGNIFYING
FULL APPROVAL OF DESIGN AND TEXT.

Customer

Crescent Pharma

Colours Used

Description

Acetazolamide 250mg Leaflet

Process Black

Item Code

P0272T

Profile

N/A

Size

148 x 315mm

Min. Point Size

8.5pt (Body) 6.25pt (Item code)

Market

UK

Language

English

Proof By

neil.everitt

Proof No.

7

Date

09/09/2014

Artwork No.

532079

Keyline - does not print

Pharma
Code

72

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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