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Lyme disease vaccine Side Effects

Applies to lyme disease vaccine: intramuscular suspension

Along with its needed effects, lyme disease vaccine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking lyme disease vaccine:

More common

  • Numbness
  • tingling
  • unusual tiredness or weakness

Less common

  • Bone pain
  • chills
  • cough
  • fever
  • muscle aches
  • runny or stuffy nose
  • shivering
  • skin rash, itching, redness, swelling, or other sign of irritation not present before vaccination
  • sneezing
  • sore throat
  • sweating


  • Difficulty swallowing
  • dizziness
  • fast heartbeat
  • headache, severe
  • puffiness or swelling around eyelids
  • shortness of breath

Some side effects of lyme disease vaccine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Back pain
  • pain in joints and/or muscles

Less common

  • Depression
  • diarrhea
  • dizziness
  • feeling unusually cold

Medically reviewed by Last updated on May 28, 2021.

More about lyme disease vaccine

Consumer resources

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.