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Levoleucovorin calcium Side Effects

In Summary

More frequently reported side effects include: diarrhea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to levoleucovorin calcium: intravenous powder for solution, intravenous solution

In addition to its needed effects, some unwanted effects may be caused by levoleucovorin calcium. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking levoleucovorin calcium, check with your doctor or nurse immediately:

More common:
  • Cloudy urine
  • decrease in urine output or decrease in urine-concentrating ability
  • difficult or labored breathing
  • fever
  • general feeling of discomfort or illness
  • lack or loss of strength
  • shortness of breath
  • stomach cramps, tenderness, or pain
  • tightness in the chest
  • unusual tiredness or weakness
  • watery or bloody diarrhea
  • wheezing
Incidence not known:
  • Feeling unusually cold
  • shivering

Minor Side Effects

Some of the side effects that can occur with levoleucovorin calcium may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Acid or sour stomach
  • bad, unusual, or unpleasant (after) taste
  • belching
  • blistering, crusting, irritation, itching, reddening, or swelling of the skin
  • burning, tingling, numbness, or pain in the hands, arms, feet, or legs
  • change in taste
  • cracked, dry, or scaly skin
  • decreased appetite
  • diarrhea
  • hair loss or thinning of the hair
  • heartburn
  • indigestion
  • loss of appetite
  • mood or mental changes
  • nausea
  • sensation of pins and needles
  • stabbing pain
  • stomach discomfort or upset
  • swelling or inflammation of the mouth
  • vomiting
  • weight loss
Incidence not known:
  • Rash

For Healthcare Professionals

Applies to levoleucovorin calcium: intravenous powder for injection, intravenous solution


Gastrointestinal side effects including stomatitis (37.5%), vomiting (37.5%), nausea (18.8%), diarrhea (6.3%), dyspepsia (6.3%), and typhlitis (6.3%) have been reported.[Ref]


Respiratory side effects including dyspnea (6.3%) have been reported.[Ref]


Dermatologic side effects including dermatitis (6.3%), pruritus, and rash have been reported.[Ref]


Other side effects including confusion (6.3%), taste perversion (6.3), temperature change, and rigors have been reported.[Ref]

Nervous system

Nervous system side effects including neuropathy (6.3%) have been reported.[Ref]


Renal side effects including abnormal renal function (6.3%) have been reported.[Ref]


Other side effects including confusion (6.3%), taste perversion (6.3), temperature change, and rigors have been reported.


1. "Product Information. Levoleucovorin (levoleucovorin)." Spectrum Chemical, Gardena, CA.

Not all side effects for levoleucovorin calcium may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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