Kefurox Side Effects

Generic name: cefuroxime

Medically reviewed by Drugs.com. Last updated on Dec 22, 2024.

Note: This document contains side effect information about cefuroxime. Some dosage forms listed on this page may not apply to the brand name Kefurox.

For healthcare professionals

Applies to cefuroxime: injectable powder for injection, intravenous solution, oral powder for reconstitution, oral tablet.

General adverse events

This drug was generally well tolerated. The side effects most commonly reported with the parenteral formulation have included neutropenia, eosinophilia, transient liver enzyme/bilirubin elevations, and injection site reactions. The side effects most commonly reported with the oral formulations have included Candida overgrowth, eosinophilia, headache, dizziness, gastrointestinal disturbances, and transient liver enzyme elevations.^[Ref]

Gastrointestinal

• Common (1% to 10%): Diarrhea/loose stools, nausea/vomiting, abdominal pain, nausea
• Uncommon (0.1% to 1%): Abdominal cramps, flatulence, indigestion, mouth ulcers, swollen tongue, dyspepsia, gastrointestinal (GI) infection, ptyalism/excess salivation, GI disturbance, vomiting
• Frequency not reported: Abdominal discomfort, dry mouth, Clostridioides difficile-associated diarrhea
• Postmarketing reports: GI disturbances (including diarrhea, nausea, vomiting, abdominal pain), pseudomembranous colitis

Cephalosporin-class:

• Frequency not reported: Vomiting, abdominal pain, colitis^[Ref]

The onset of pseudomembranous colitis symptoms has been reported during or after antibacterial therapy.^[Ref]

Hepatic

• Common (1% to 10%): Transient increase in AST, transient increase in ALT, transient increase in liver enzyme levels
• Uncommon (0.1% to 1%): Transient increase in bilirubin
• Postmarketing reports: Hepatic dysfunction, hepatitis, cholestasis, jaundice (mainly cholestatic)

Cephalosporin-class:

• Frequency not reported: Hepatic dysfunction (including cholestasis)^[Ref]

Nervous system

• Common (1% to 10%): Headache, dizziness
• Uncommon (0.1% to 1%): Sleepiness, somnolence, hyperactivity
• Postmarketing reports: Seizures, encephalopathy^[Ref]

Cephalosporin-class antibiotics (including this drug) have been associated with seizures, especially in patients with renal dysfunction when the dose was not reduced.^[Ref]

Hypersensitivity

• Common (1% to 10%): Delayed hypersensitivity reaction
• Uncommon (0.1% to 1%): Hypersensitivity reactions (including rash, pruritus, urticaria)
• Rare (0.01% to 0.1%): Severe hypersensitivity reactions
• Frequency not reported: Serum sickness
• Postmarketing reports: Anaphylaxis, serum sickness-like reaction^[Ref]

Delayed hypersensitivity reaction to this drug has been reported in 2.9% of patients with history of delayed hypersensitivity to penicillin (but not a cephalosporin).

Rare cases of severe hypersensitivity reactions (including erythema multiforme, toxic epidermal necrolysis [exanthematic necrolysis], drug fever, serum sickness-like reaction, anaphylaxis, Stevens-Johnson syndrome) have been reported.^[Ref]

Hematologic

• Common (1% to 10%): Eosinophilia, decreased hemoglobin and hematocrit, neutropenia, decreased hemoglobin concentration
• Uncommon (0.1% to 1%): Positive Coombs test, leukopenia, thrombocytopenia
• Frequency not reported: Autoimmune granulocytopenia, increased coagulation time
• Postmarketing reports: Hemolytic anemia, pancytopenia, increased prothrombin time

Cephalosporin-class:

• Frequency not reported: Aplastic anemia, hemolytic anemia, hemorrhage, prolonged prothrombin time, pancytopenia, agranulocytosis, positive Coombs test^[Ref]

Profound leukopenia has sometimes been profound with oral therapy.^[Ref]

Renal

• Frequency not reported: Increased BUN, increased creatinine, decreased CrCl, acute renal failure
• Postmarketing reports: Renal dysfunction, interstitial nephritis (including reversible fever, azotemia, pyuria, eosinophilia)

Cephalosporin-class:

• Frequency not reported: Toxic nephropathy^[Ref]

Acute renal failure has been reported. Renal function improved after this drug was stopped, and deteriorated upon rechallenge.^[Ref]

Genitourinary

• Common (1% to 10%): Vaginitis
• Uncommon (0.1% to 1%): Vulvar itch, dysuria, vaginal candidiasis, vaginal discharge, vaginal itch, urethral pain/bleeding, kidney pain, urinary tract infection, vaginal irritation

Cephalosporin-class:

• Frequency not reported: Vaginitis (including vaginal candidiasis)^[Ref]

Dermatologic

• Common (1% to 10%): Diaper/nappy rash
• Uncommon (0.1% to 1%): Rash, urticaria/hives, pruritus, erythema
• Rare (0.01% to 0.1%): Erythema multiforme, toxic epidermal necrolysis (exanthematic necrolysis), Stevens-Johnson syndrome
• Frequency not reported: Acute generalized exanthematous pustulosis
• Postmarketing reports: Angioedema/angioneurotic edema, urticaria, toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme, cutaneous vasculitis

Beta-lactam antibiotics:

• Frequency not reported: Severe cutaneous adverse reactions (including Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms [DRESS], acute generalized exanthematous pustulosis)^[Ref]

A case of occupational contact dermatitis due to cephalosporin allergy has been reported in a nurse who prepared cephalosporin solutions for administration to patients. The dermatitis resolved after the nurse stopped preparing the solutions.^[Ref]

Metabolic

• Uncommon (0.1% to 1%): Anorexia

Cephalosporin-class:

• Frequency not reported: Urine glucose false positive^[Ref]

Other

• Common (1% to 10%): Transient increase in LDH, transient increase in alkaline phosphatase, Candida overgrowth, dislike of taste
• Uncommon (0.1% to 1%): Chest pain/tightness, chills, thirst, viral illness, candidiasis, fever
• Rare (0.01% to 0.1%): Drug fever
• Frequency not reported: C difficile overgrowth, disulfiram reaction^[Ref]

Respiratory

• Uncommon (0.1% to 1%): Shortness of breath, sinusitis, cough, upper respiratory infection^[Ref]

Musculoskeletal

• Uncommon (0.1% to 1%): Muscle cramps, muscle stiffness, muscle spasm of the neck, lockjaw-type reaction, joint swelling, arthralgia^[Ref]

Cardiovascular

• Uncommon (0.1% to 1%): Tachycardia
• Frequency not reported: Kounis syndrome type I variant
• Postmarketing reports: Acute myocardial ischemia (with or without myocardial infarction)^[Ref]

A 90-year-old man, with no history of coronary artery disease, diabetes mellitus, hypertension, or hyperlipidemia, was administered 750 mg cefuroxime axetil IM for urinary tract infection. About 10 minutes after the injection, the patient developed chest pain and pruritic skin rashes. Kounis syndrome type I variant was diagnosed secondary to the drug. Five days after stopping the drug, the patient's symptoms had resolved.

Acute myocardial ischemia (with or without myocardial infarction) has occurred as part of an allergic reaction.^[Ref]

Local

• Common (1% to 10%): Injection site reactions (including pain, thrombophlebitis), thrombophlebitis with IV administration, phlebitis, transient pain at injection site
• Frequency not reported: Pain at IM injection site^[Ref]

Immunologic

• Common (1% to 10%): Jarisch-Herxheimer reaction^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Irritable behavior

See also:

Further information

Kefurox side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

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