Skip to Content

Guanidine Hydrochloride Side Effects

Generic Name: guanidine

Note: This document contains side effect information about guanidine. Some of the dosage forms listed on this page may not apply to the brand name Guanidine Hydrochloride.

Applies to guanidine: oral tablet

Along with its needed effects, guanidine (the active ingredient contained in Guanidine Hydrochloride) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking guanidine:

Incidence Not Known

  • Ammonia-like breath odor
  • black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in frequency or amount of urine
  • chest pain
  • chills
  • cloudy urine
  • cold sensations in the hands and feet
  • confusion
  • cough
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever
  • increased thirst
  • loss of appetite
  • nausea or vomiting
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • shakiness in the legs, arms, hands, or feet
  • shortness of breath, especially with exercise
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • sweating
  • swollen glands
  • unsteadiness, trembling, or problems with muscle control
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • weight loss

Some side effects of guanidine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence Not Known

  • Abdominal or stomach cramps
  • burning, itching, and pain in hairy areas
  • crying for no reason
  • dry mouth
  • dryness and scaling of the skin
  • false or unusual sense of well-being
  • feeling irritated
  • feeling of warmth
  • feeling paranoid
  • jitteriness
  • large, flat, blue or purplish patches in the skin
  • mood or mental changes
  • pinpoint red or purple spots on the skin
  • quick to react or overreact emotionally
  • rash
  • redness of the face, neck, arms, and occasionally, upper chest
  • restlessness
  • seeing or hearing things that are not there

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

More about Guanidine Hydrochloride (guanidine)

Consumer resources

Professional resources