Skip to Content

Gammagard Side Effects

Generic Name: immune globulin intravenous and subcutaneous

Note: This page contains information about the side effects of immune globulin intravenous and subcutaneous. Some of the dosage forms included on this document may not apply to the brand name Gammagard.

For the Consumer

Applies to immune globulin intravenous and subcutaneous: injectable solution

Get emergency medical help if you have any of these signs of an allergic reaction while taking immune globulin intravenous and subcutaneous (the active ingredient contained in Gammagard) hives; wheezing, difficulty breathing; dizziness, feeling like you might pass out; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • signs of a blood clot in the brain--sudden numbness or weakness (especially on one side of the body), slurred speech, problems with vision or balance;

  • signs of a blood clot in the heart or lung--chest pain, rapid heart rate, sudden cough, wheezing, rapid breathing, coughing up blood;

  • signs of a blood clot in your leg--pain, swelling, warmth, or redness in one or both legs;

  • signs of a kidney problem--swelling, rapid weight gain, and little or no urinating;

  • liver problems--fast heart rate, dark urine, jaundice (yellowing of the skin or eyes);

  • lung problems--chest pain, trouble breathing, blue lips, pale or blue colored appearance in your fingers or toes; or

  • signs of new infection--high fever, flu symptoms, mouth sores, severe headache, neck stiffness, increased sensitivity to light, nausea and vomiting.

Common side effects may include:

  • dizziness, tired feeling;

  • sore throat;

  • joint or muscle pain;

  • diarrhea; or

  • mild itching or rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to immune globulin intravenous and subcutaneous: injectable solution


The most common adverse events were headache and injection/infusion site reactions.[Ref]


Very common (10% or more): Infusion site reaction (75%)
Common (1% to 10%): Injection site reaction
Frequency not reported: Hives/urticaria, itching

Nervous system

Very common (10% or more): Headache (58%)
Common (1% to 10%): Dizziness
Postmarketing reports: Aseptic meningitis, coma, loss of consciousness, seizures/convulsions, tremor[Ref]


Very common (10% or more): Ecchymosis/purpura (40%), petechiae (21%), rash (10%)
Common (1% to 10%): Pruritus, urticaria
Frequency not reported: Hives
Postmarketing reports: Stevens-Johnson syndrome, epidermolysis, erythema multiforme, bullous dermatitis[Ref]


Very common (10% or more): Hemorrhage (all systems) (29%), thrombocytopenia (15%)
Common (1% to 10%): Anemia
Uncommon (0.1% to 1%): Coombs negative hypochromic anemia, autoimmune pure red cell aplasia, exacerbation of autoimmune pure red cell aplasia
Postmarketing reports: Hemolytic anemia, pancytopenia, leukopenia, hemolysis, positive direct antiglobulin (Coombs test)[Ref]


Very common (10% or more): Diarrhea (28%), nausea (21%), vomiting (21%)
Common (1% to 10%): Abdominal pain, dyspepsia[Ref]


Very common (10% or more): Cough increased (54%), rhinitis (51%), pharyngitis (41%), asthma (29%), epistaxis (23%)
Common (1% to 10%): Influenza, flu syndrome, sinusitis
Postmarketing reports: Apnea, acute respiratory distress syndrome (ARDS), transfusion related acute lung injury (TRALI), cyanosis, hypoxemia, pulmonary edema, dyspnea, bronchospasm[Ref]


Common (1% to 10%): Hypertension
Frequency not reported: Myocarditis
Postmarketing reports: Cardiac arrest, thromboembolism, vascular collapse, hypotension[Ref]


Very common (10% or more): Elevated ALT (18%), alkaline phosphatase elevated (13%)
Common (1% to 10%): AST elevated, low alkaline phosphatase
Postmarketing reports: Hepatic dysfunction[Ref]


Very common (10% or more): Fever (28%), ear pain (18%), accidental injury (13%), asthenia (10%)
Common (1% to 10%): Fatigue
Postmarketing reports: Rigors


Common (1% to 10%): Arthralgia, back pain, neck pain
Uncommon (0.1% to 1%): Severe chills[Ref]


Frequency not reported: Anxiety


1. "Product Information. Gamunex-C (immune globulin intravenous and subcutaneous)." Talecris Biotherapeutics, Research Triangle Park, NC.

Not all side effects for Gammagard may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.