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Chymopapain Side Effects

Applies to chymopapain: injection powder for solution

Along with its needed effects, chymopapain may cause some unwanted effects. Very rarely, use of chymopapain has caused serious side effects, including paralysis of the legs or death. Also, this medicine may cause dangerous allergic reactions, especially in women.

Severity: Moderate

If any of the following side effects occur while taking chymopapain, check with your doctor or nurse as soon as possible:

  • Abdominal or stomach cramps or pain
  • changes in facial skin color
  • constipation (severe)
  • convulsions (seizures)
  • decreased or uncontrolled urination
  • fast or irregular breathing
  • headache (sudden, severe, and continuing)
  • hot skin
  • pain, tenderness, swelling and/or skin color changes of the leg or foot
  • puffiness or swelling of the eyelids or around the eyes
  • runny nose
  • shortness of breath, troubled breathing, tightness in chest, or wheezing
  • skin rash, redness, hives, or itching
  • swelling of abdomen or stomach
  • uncontrolled bowel movements
  • vomiting
  • weakness in legs (severe) or problems with moving legs

Other side effects may occur that usually do not need medical attention. Pain and muscle spasms in the lower back may last for several days after you have received this medicine. Stiffness or soreness in the back may last for several months. Other side effects may go away after a short time. However, check with your doctor if any of the following side effects continue or are bothersome:

More common:
  • Back pain, stiffness, or soreness
  • muscle spasms in lower back
Less common or rare:
  • Cramps, pain, or mild weakness in legs
  • decreased sensitivity to pain
  • dizziness
  • feeling of burning in lower back
  • foot drop
  • headache
  • nausea
  • numbness or tingling in legs or toes

Severity: Moderate

If any of the following side effects occur while taking chymopapain, check with your doctor or nurse as soon as possible:

  • Back pain or muscle weakness (sudden and severe)
  • skin rash, hives, or itching

Not all side effects for chymopapain may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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