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Generic name: chloramphenicol
Dosage form: ophthalmic solution and ointment
Drug class: Ophthalmic anti-infectives

Medically reviewed by Last updated on Jun 21, 2021.

Bone marrow hypoplasia, including aplastic anemia and death has been reported following local application of chloramphenicol. Chloramphenicol should not be used when less potentially dangerous agents would be expected to provide effective treatment.


Econochlor® (Chloramphenicol) is a sterile topical ophthalmic antibacterial prepared in solution and ointment forms. The active ingredient is represented by the chemical structure:

Established name:


Chemical name:

Acetamide, 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2- (4-nitrophenyl) ethyl]-, [R-(R*,R)]-

Each ml of solution contains: Active: Chloramphenicol 0.5% (5mg/ml). Preservative: Thimerosal 0.01%. Vehicle: Hydroxypropyl Methylcellulose: Inactive: Boric Acid, Sodium Borate (to adjust pH), Purified Water.


Each gram of ointment contains: Active: Chloramphenicol 1.0% (10 mg/g). Inactive: Mineral Oil, Anhydrous Liquid Lanolin, White Petrolatum.



Chloramphenicol is a broad-spectrum antibiotic originally isolated from Streptomyces venezuelae. It is primarily bacteriostatic and acts by inhibition of protein synthesis by interfering with the transfer of activated amino acids from soluble RNA to ribosomes. Development of resistance to chloramphenicol can be regarded as minimal for staphylococci and many other species of bacteria.


Chloramphenicol should be used only in those serious infections for which less potentially dangerous drugs are ineffective or contraindicated. Bacteriological studies should be performed to determine the causative organisms and their sensitivity to chloramphenicol (See Box Warning). For treatment of ocular infections involving the conjunctiva and/or cornea caused by chloramphenicol-susceptible organisms.

Chloramphenicol has a wide spectrum of antimicrobial activity and is effective against many gram negative and gram positive bacteria, including the following common eye pathogens:

Staphylococcus aureus

Streptococci, including Streptococcus pneumoniae

Escherichia coli

Haemophilus influenzae

Klebsiella/Enterobacter species

Neisseria species

Moraxella lacunata (Morax-Axenfeld bacillus)

The product does not provide adequate coverage against:

Pseudomonas aeruginosa

Serratia marcescens


This product is contraindicated in those persons who have shown hypersensitivity to any of its components.



Ophthalmic ointment may retard corneal wound healing.


Prolonged use of antibiotics may occasionally result in overgrowth of non-susceptible organisms, including fungi. If new infections appear during treatment, the therapy should be altered. In all serious infections, the topical use of chloramphenicol should be supplemented by appropriate systemic medication.


Blood dyscrasias may be associated with the systemic use of chloramphenicol. One case of bone-marrow hypoplasia following the prolonged (23 month) topical use of chloramphenicol ophthalmic solution has been reported.


Solution: In severe disease, instill two drops on the eye(s) hourly until improvement, following which treatment should be diminished prior to discontinuation. In mild disease, drops may be used four times daily. Ointment: Apply a small amount to the lower conjunctival sac(s) at bedtime as a supplement to the drops.


Solution in 5ml (2.5ml fill) and 15ml plastic Drop-Tainer® dispensers. Ointment in 3.5 gram ophthalmic tube. Rx only.

2.5ml NDC 0065-0642-25

15ml NDC 0065-0642-15

3.5 g NDC 0065-0641-35


Solution: Refrigerate until dispensed. Ointment: Store between 46° and 80°F.

June, 1984
Printed in USA

Alcon Laboratories, Inc.
Fort Worth, Texas 76134 USA

chloramphenicol solution
Product Information
Product Type HUMAN PRESCRIPTION DRUG LABEL Item Code (Source) NDC:0065-0642
Route of Administration OPHTHALMIC DEA Schedule
Active Ingredient/Active Moiety
Ingredient Name Basis of Strength Strength
chloramphenicol (chloramphenicol) chloramphenicol 5 mg in 1 mL
Inactive Ingredients
Ingredient Name Strength
hydroxypropyl methylcellulose
boric acid
sodium borate
# Item Code Package Description
1 NDC:0065-0642-25 2.5 mL (2.5 MILLILITER) in 1 BOTTLE, PLASTIC
2 NDC:0065-0642-15 15 mL (15 MILLILITER) in 1 BOTTLE, PLASTIC
chloramphenicol ointment
Product Information
Product Type HUMAN PRESCRIPTION DRUG LABEL Item Code (Source) NDC:0065-0641
Route of Administration OPHTHALMIC DEA Schedule
Active Ingredient/Active Moiety
Ingredient Name Basis of Strength Strength
chloramphenicol (chloramphenicol) chloramphenicol 10 mg in 1 g
Inactive Ingredients
Ingredient Name Strength
mineral oil
anhydrous liquid lanolin
white petrolatum
# Item Code Package Description
1 NDC:0065-0641-35 3.5 g (3.5 GRAM) in 1 TUBE
Labeler - Alcon Laboratories, Inc.
Alcon Laboratories, Inc.

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