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Trypsin / Balsam Peru / Castor Oil

Pronunciation: TRIP-sin/BOLL-sam peh-RUH/KASS-ter oil
Class: Enzyme combination, topical

Trade Names

- Aerosol 0.12 mg trypsin/87 mg balsam Peru/788 mg castor oil per g

- Gel 0.12 mg tyrpsin/87 mg balsam Peru/788 mg castor oil per g


Physiologically debrides tissue; improves epithelization by reducing premature epithelial desiccation and cornification.

Indications and Usage

In acute and chronic conditions such as varicose ulcers, decubital ulcers, eschar, dehiscent wounds and sunburn, relieves pain and promotes healing; debrides eschar and necrotic tissue; stimulates vascular bed; improves epithelization; reduces odor from necrotic wounds.


None well documented.

Dosage and Administration


Apply a minimum of twice daily or as often as necessary.

General Advice

  • For external use only. Avoid contact with eyes.
  • Shake aerosol can well and hold upright approximately 12 inches from the area to be treated.
  • Do not apply to fresh arterial clots.
  • The wound may be left unbandaged or appropriate dressing applied.
  • To remove, wash gently.


Store between 59° and 86°F. Avoid freezing. Do not expose aerosol can to temperatures above 120°F. Do not expose aerosol can to fire or open flame.

Drug Interactions

None well documented.

Adverse Reactions


Stinging or burning sensation; irritation.



Category undetermined.



Patient Information

  • Advise patient, family, or caregiver that medication will usually be prepared and applied by a health care provider in a medical setting but may also be used in a home environment.
  • Review prescribed dosing schedule and application process with patient, parent, or caregiver.
  • Advise patient, parent, or caregiver that spray may produce a temporary stinging sensation when applied to sensitive skin, but that this should be tolerable. If it persists or is intolerable, notify health care provider.

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