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- Tablets, chewable 500 mg
Inhibits helminth-specific enzyme fumarate reductase; suppresses egg or larval production and may inhibit subsequent development of eggs or larvae that are passed in the stool.
Thiabendazole is rapidly absorbed. T max is within 1 to 2 h.
Thiabendazole is almost completely metabolized to the 5-hydroxy form, which appears in the urine as glucuronide or sulfate conjugates.
In 48 h, about 5% of a thiabendazole dose is recovered from feces and 90% from urine.
Indications and Usage
Treatment of strongyloidiasis (threadworm infection), cutaneous larva migrans (creeping eruption), and visceral larva migrans alone or in conjunction with enterobiasis (pinworm). Secondary therapy for uncinariasis (hookworm: Necator americanus and Ancylostoma duodenale ), trichuriasis (whipworm), and ascariasis (large roundworm); alleviation of symptoms of trichinosis during invasive phase.
Dosage and AdministrationAdults at least 150 lb (68 kg)
PO 1.5 g/dose twice daily (max, 3 g/day).Adults and Children 30 to 150 lb (13.6 to 68 kg)
PO 10 mg/lb/dose (22 mg/kg/dose) (max, 3 g/day).Strongyloidiasis, Ascariasis, Uncinariasis, Trichuriasis, Cutaneous larva migrans
Two doses daily for 2 successive days (may repeat for some indications).Trichinosis
Two doses daily for 2 to 4 successive days.Visceral larva migrans
Two doses daily for 7 successive days.
Store at room temperature.
Thiabendazole may increase serum concentrations of theophylline to potentially toxic levels.
Laboratory Test Interactions
None well documented.
Dizziness; fatigue; drowsiness; giddiness; headache; numbness; hyperirritability; seizures; collapse.
Tinnitus; abnormal sensation in eyes; xanthopsia; blurring of vision; drying of mucous membranes; appearance of live ascaris in mouth and nose.
Anorexia; nausea; vomiting; diarrhea; epigastric distress.
Hematuria; enuresis; malodor of urine; crystalluria.
Jaundice; cholestasis; parenchymal liver damage, transient rise in cephalin flocculation and AST.
Hypersensitivity reaction (pruritus, fever, facial flush, chills, conjunctival injection (red eye), angioedema, anaphylaxis, skin rashes, erythema multiforme, lymphadenopathy).
Category C .
Safety and efficacy in children weighing less than 13.6 kg (30 lb) not established.
Mixed infections with Ascaris lumbricoides
Thiabendazole may cause these worms to migrate. Drug should not be used prophylactically.
Anemic, dehydrated, or malnourished patients may need concomitant therapy to reverse these conditions.
Transient visual disturbances, psychic alterations.
- Instruct patient to take medicine with food. No special diets are needed.
- Advise patient that all family members should be treated and that treatment may need to be repeated in 7 days to prevent reinfection.
- Instruct patient to bathe daily and to launder bed linens, clothes, and towels daily. Instruct patient on proper technique for hygiene and hand-washing.
- Advise patient to avoid consuming excessive amounts of caffeine-containing beverages, such as coffee.
- Instruct patient to inform health care provider immediately of any symptoms of hypersensitivity or overdosage.
- Advise patient that drug can cause drowsiness and dizziness and to use caution while driving or performing other tasks requiring mental alertness.
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