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Class: Anti-infective agent
- Powder for injection 400 mg (as hydrochloride) per mL when reconstituted
Inhibits protein synthesis in bacterial cells (30S ribosomal subunit).
Rapid after IM injection. Following a 2 g dose, C max is about 100 mcg/mL at approximately 1 h; and 160 mcg/mL 2 h after a 4 g dose. Eight hours after a 2 or 4 g dose, average serum levels are 15 and 31 mcg/mL, respectively.
Indications and Usage
Treatment of acute gonorrheal urethritis and proctitis in men and acute gonorrheal cervicitis and proctitis in women.
Dosage and AdministrationAdults
IM 2 g deep into upper outer quadrant of the gluteal muscle. In geographic locations where antibiotic resistance is known to be prevalent, treat with 4 g divided between 2 gluteal injection sites.
Store unopened vials at controlled room temperature (68° to 77°F). Store reconstituted suspension at controlled room temperature and use within 24 h. Discard any unused solution. Do not save unused solution for later administration.
None well documented.
Laboratory Test Interactions
None well documented.
Soreness at injection site; urticaria.
Decreased urine output.
Anaphylaxis or anaphylactoid reactions.
Decreased hemoglobin, hematocrit, and Ccr; elevated alkaline phosphatase, BUN, and ALT.
Category B .
Safety and efficacy not established.
Contains benzyl alcohol, which has been associated with fatal gasping syndrome in premature infants and increased incidence of neurologic and other complications.
Monitor to detect evidence of Neisseria gonorrhoeae resistance.
Spectinomycin is not effective in treating syphilis, and high doses for short periods of time to treat gonorrhea may mask or delay symptoms of incubating syphilis.
- Advise patient or caregiver that medication will be prepared and administered by a health care provider in a health care setting.
- Advise patient to report injection-site pain or redness.
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