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Pronunciation: pir-IL-a-meen TAN-nate
- Suspension 12 mg per 5 mL
Suppresses symptoms of allergic rhinitis.
Indications and Usage
Symptomatic relief of acute rhinitis and nasal congestion associated with the common cold, seasonal and perennial allergic rhinitis, sinusitis, and other respiratory tract conditions.
Newborns; breast-feeding women; hypersensitivity.
Dosage and AdministrationAdults and Children 12 yr of age and older
PO 12 to 24 mg (5 to 10 mL) every 12 h (max, 48 mg per 24 h).Children 6 to 12 yr of age
PO 12 mg (5 mL) every 12 h (max, 24 mg per 24 h).Children 2 to 6 yr of age
PO 6 mg (2.5 mL) every 12 h (max, 12 mg per 24 h).
- Shake well before using.
Store at 59° to 86°F. Protect from light and freezing.
Drug InteractionsAlcohol, CNS depressants (eg, hypnotics, sedatives, tranquilizers)
May have additive CNS effects (eg, increased drowsiness).Antihypertensives (eg, mecamylamine, methyldopa, reserpine, veratrum alkaloids)
Antihypertensive effects may be reduced.Beta-blockers (eg, propranolol)
Effects of pyrilamine may be increased.MAOIs
Do not use with or within 14 days after stopping MAOI therapy.Sympathomimetics
Increased risk of mild sedation or stimulation.
Laboratory Test Interactions
None well documented.
CNS depression, drowsiness, sedation.
Dryness of mucous membranes.
Urinary retention in patients with prostatic hypertrophy.
Monitor renal function in elderly patients.
Category C .
Safety and efficacy not established in children younger than 2 yr of age.
Use with caution because of increased likelihood of decreased renal function, increasing the risk of dizziness, hypertension, and sedation.
Risk of toxicity may be increased in patients with renal function impairment.
Special Risk Patients
Use with caution in patients with CV disease, diabetes, hypertension, hyperthyroidism, narrow-angle glaucoma, or prostatic hypertrophy.
May cause excitation, particularly in children.
Atropine-like signs and symptoms, CNS stimulation or depression. CNS depression, convulsions, death, diminished mental alertness, excitation, hallucinations, or respiratory or cardiac arrest in infants and children.
- Caution patients to avoid drinking alcoholic beverages and using other depressants.
- Advise patients that drug may cause drowsiness and to use caution while driving or performing other tasks requiring mental alertness or coordination.
Copyright © 2009 Wolters Kluwer Health.