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Probenecid / Colchicine
Class: Agents for gout
Probenecid and Colchicine
- Tablets 500 mg probenecid and 0.5 mg colchicine
Inhibits tubular reabsorption of urate, thus increasing urinary excretion of uric acid.Colchicine
Inhibits inflammation and reduces pain and swelling associated with gouty arthritis.
Indications and Usage
Treatment of chronic gouty arthritis when complicated by frequent, recurrent, acute attacks of gout.
Hypersensitivity to any component of product; children younger than 2 yr of age; known blood dyscrasias; uric acid kidney stones; current acute gouty attack.
Dosage and AdministrationAdults
PO 1 tablet/day for 7 days, then 1 tablet twice daily thereafter. If necessary, the daily dosage may be increased by 1 tablet at 4-wk intervals as tolerated (usually not more than 4 tablets/day).
Administer without regard to meals. Administer with food if GI upset occurs.
Store tablets at controlled room temperature (59° to 86°F).
Drug InteractionsAcetaminophen, indomethacin, ketoprofen, lorazepam, meclofenamate, naproxen, rifampin
Plasma levels of these agents may be increased.Beta-lactam antibiotics, penicillins
Psychic disturbances may occur.Induction anesthesia (eg, thiopental)
Less anesthetic may be required.Methotrexate
Probenecid increases plasma levels; methotrexate dose may need to be reduced.Pyrazinamide, salicylates
Uricosuric action of probenecid may be antagonized.Sulfonamides
Total sulfonamide (drug plus metabolite) levels may be increased.Sulfonylureas
Risk of hypoglycemia may be increased.
Laboratory Test Interactions
Falsely high reading for theophylline may occur when measured by the Schack and Waxler technique.
Urticaria; pruritus; dermatitis; alopecia; flushing.Colchicine
Urticaria; purpura; alopecia; dermatitis.
Vomiting; nausea; anorexia; sore gums.Colchicine
Nausea; vomiting; abdominal pain; diarrhea.
Nephrotic syndrome; uric acid stones with or without hematuria; renal colic; costovertebral pain; urinary frequency.
Aplastic anemia; leukopenia; hemolytic anemia.Colchicine
Aplastic anemia; agranulocytosis.
Precipitation of acute gouty arthritis.
Category C .
Safety and efficacy not established; contraindicated in children younger than 2 yr of age.
May not be effective in patients with chronic renal function impairment (30 mL/min or less); dose may need to be increased.
Alkalinization of urine
May be needed to prevent hematuria, renal colic, costovertebral pain, formation of uric acid stones.
Exacerbation of gout
Use with caution in patients with history of peptic ulcer disease.
Diarrhea, generalized vascular damage, renal damage, hematuria, oliguria.
- Advise patient to take tablets as prescribed by health care provider.
- Advise patient to take without regard to meals but to take with food if GI upset occurs.
- Inform patient that dose will be slowly increased until max benefit is obtained.
- Advise patient to maintain adequate fluid intake (at least eight 8 oz glasses of water/day) and to carefully follow any instructions regarding alkalinizing the urine that were provided by health care provider.
- Caution patient to not increase the dose of this medication if gout symptoms should recur. Instruct patient to discuss other treatments for acute gout while continuing this medication.
- Caution patient to avoid concurrent use of aspirin or aspirin-containing products. Advise patient to use acetaminophen for management of mild to moderate pain.
- Advise patient to stop taking the drug and notify health care provider if persistent diarrhea or other GI symptoms occur, or if a rash or other signs of an allergic reaction develop.
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