Prednisolone Acetate / Neomycin Sulfate / Polymyxin B Sulfate
Pronunciation: pred-NISS-oh-lone ASS-uh-TATE/NEE-oh-MY-sin SULL-fate/pahl-ee-MIX-in BEE SULL-fate
Class: Corticosteroid, Antibacterial
- Ophthalmic Suspension prednisolone acetate 0.5%/neomycin sulfate equiv. to 0.35% neomycin base/polymyxin B sulfate 10,000 units per mL
Suppresses the inflammatory response to a variety of agents; may delay or slow healing.Neomycin
Inhibits protein synthesis by binding to ribosomal RNA, causing bacterial genetic code misreading.Polymyxin B
Interacts with phospholipid components of bacterial cell membrane, increasing cell wall permeability.
Indications and Usage
Treatment of steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where bacterial infection or a risk of bacterial ocular infection exists; inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe where the inherent risk of steroid use in certain infective conjunctivitis is accepted to obtain a diminution in edema and inflammation; chronic anterior uveitis and corneal injury from chemical, radiation, or thermal burns or penetration of foreign bodies; when risk of infection is high or where there is expectation that potentially dangerous numbers of bacteria will be present in the eye.
Epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, varicella, and many other viral diseases of the corneal and conjunctiva; mycobacterial eye infections; fungal diseases of the ocular structures; uncomplicated removal of a corneal foreign body; hypersensitivity to any component of the product.
Dosage and AdministrationEye
Ophthalmic Instill 1 or 2 drops in the eye(s) every 3 or 4 h or more frequently as required. Acute infections may require administration every 30 min, with decreasing frequency as the infection is brought under control.Lids
Ophthalmic Instill 1 or 2 drops in the eye(s) every 3 to 4 h, close the eye, and rub the excess on the lids and lid margins.
- For ophthalmic use only. Not for use in the ears or on the skin.
- Shake well before instilling drops.
- Do not allow tip of dropper bottle to touch eye, eyelid, fingers, or any other surface.
- If using other topical ophthalmic medications, instill drops first, wait at least 5 min, and instill ointment last.
Store at controlled room temperature (less than 77°F). Keep bottle tightly capped and protect from freezing.
None well documented.
Acute anterior uveitis and perforation of the globe, conjunctival hyperemia, conjunctivitis, corneal ulcers, delayed wound healing, elevated IOP with possible development of glaucoma, infrequent optic nerve damage, keratitis, posterior subcapsular cataract formation.
Allergic sensitizations, including itching, swelling, and conjunctival swelling; rarely, anaphylaxis.
Fungal infection, secondary infection.
Category C .
Excreted in breast milk.
Safety and efficacy have not been established.
Prolonged use may result in bacterial or fungal overgrowth of nonsusceptible microorganisms.
Allergic cross-sensitivity to kanamycin, paromomycin, streptomycin, and, possibly, gentamicin may occur.
Prolonged use may result in glaucoma with damage to the optic nerve, defects in visual acuity and fields of vision, and posterior subcapsular cataract formation.
Bacterial resistance may develop.
Secondary bacterial ocular infection following suppression of host responses may occur.
- Review prescribed dosing schedule with patient, family, or caregiver.
- Remind patient, family, or caregiver that suspension is for use in the eye only.
- Teach patient, family, or caregiver proper technique for instilling suspension: wash hands; do not allow tip of dropper bottle to touch eye, eyelid, fingers, or any other surface. Tilt head back, look up; pull lower eyelid down to form pocket; place prescribed number of drops in the pocket. Look downward before closing eye. Do not rub eye.
- Advise patient, family, or caregiver that if more than 1 topical ophthalmic drug is being used, instill eye drops first, wait at least 5 min and then instill ointment last.
- Inform patient that temporary blurred vision and stinging of the eye are the most common side effects and to contact health care provider if these symptoms occur and are bothersome.
- Advise patient to contact eye doctor if eye or eyelid inflammation is noted or if eye symptoms do not improve or worsen.
- Advise patient that the entire course of therapy must be completed to ensure maximal benefit and to complete full course of therapy even if symptoms have resolved.
- Instruct patient not to wear contact lenses during treatment.
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