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Oxiconazole

Medically reviewed by Drugs.com. Last updated on Sep 2, 2020.

Pronunciation

(oks i KON a zole)

Index Terms

  • Oxiconazole Nitrate

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Cream, External:

Oxistat: 1% (30 g, 60 g, 90 g) [contains benzoic acid, cetyl alcohol, propylene glycol]

Generic: 1% (30 g, 60 g, 90 g)

Lotion, External:

Oxistat: 1% (30 mL, 60 mL) [contains benzoic acid, cetyl alcohol, propylene glycol]

Brand Names: U.S.

  • Oxistat

Pharmacologic Category

  • Antifungal Agent, Imidazole Derivative
  • Antifungal Agent, Topical

Pharmacology

The cytoplasmic membrane integrity of fungi is destroyed by oxiconazole which exerts a fungicidal activity through inhibition of ergosterol synthesis. Effective for treatment of tinea pedis, tinea cruris, tinea corporis, and tinea versicolor. Active against Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton violaceum, Microsporum canis, Microsporum audouinii, Microsporum gypseum, Epidermophyton floccosum, Candida albicans, and Malassezia furfur.

Absorption

In each layer of the dermis; very little systemically after one topical dose

Distribution

To each layer of the dermis

Excretion

Urine (<0.3%)

Use: Labeled Indications

Cream: Topical treatment of tinea pedis (athlete's foot); tinea cruris (jock itch); tinea corporis (ringworm) due to Trichophyton rubrum, Trichophyton mentagrophytes, or Epidermophyton floccosum; and tinea (pityriasis) versicolor due to Malassezia furfur

Lotion: Treatment of tinea pedis (athlete's foot); tinea cruris (jock itch); tinea corporis (ringworm) due to Trichophyton rubrum, Trichophyton mentagrophytes, or Epidermophyton floccosum

Contraindications

Hypersensitivity to oxiconazole or any component of the formulation

Dosing: Adult

Tinea corporis/tinea cruris: Topical: Cream, lotion: Apply to affected areas 1 to 2 times daily for 2 weeks

Tinea pedis: Topical: Cream, lotion: Apply to affected areas 1 to 2 times daily for 1 month

Tinea versicolor: Topical: Cream: Apply to affected areas once daily for 2 weeks

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Tinea corporis, tinea cruris, tinea pedis, tinea versicolor: Children ≥12 years and Adolescents: Topical: Cream: Refer to adult dosing.

Administration

For external use only; avoid contact with eyes, nose, mouth, or other mucous membranes. Avoid occlusive dressings. Wash hands before and after use.

Storage

Store between 15°C to 30°C (59°F to 86°F). Shake lotion well before use.

Drug Interactions

There are no known significant interactions.

Adverse Reactions

1% to 10%:

Central nervous system: Localized burning (≤1%)

Dermatologic: Pruritus (<2%)

<1%, postmarketing, and/or case reports: Allergic contact dermatitis, dyshidrotic eczema, erythema, exfoliation of skin, folliculitis, maceration of the skin, nodule, pain, papule, skin fissure, skin irritation, skin rash, stinging of the skin, tingling of skin

Warnings/Precautions

Concerns related to adverse effects:

• Irritation: Discontinue if sensitivity or irritation occurs

Other warnings/precautions:

• Appropriate use: For topical use only; not for ophthalmologic, oral, or vaginal use.

Pregnancy Risk Factor

B

Pregnancy Considerations

When administered orally, teratogenic effects were not observed in animal reproduction studies.

Patient Education

What is this drug used for?

• It is used to treat fungal infections of the skin.

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Severe application site irritation, blistering, swelling, burning, oozing, or bleeding

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.

Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.