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(ne doe KROE mil)

Index Terms

  • Nedocromil Sodium

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution, Ophthalmic, as sodium:

Alocril: 2% (5 mL) [contains benzalkonium chloride]

Brand Names: U.S.

  • Alocril

Pharmacologic Category

  • Mast Cell Stabilizer


Inhibits the activation of and mediator release from a variety of inflammatory cell types associated with hypersensitivity reactions including eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets; it inhibits the release of histamine, leukotrienes, and slow-reacting substance of anaphylaxis.


Low (<4%)


Urine 70% (as unchanged drug); feces 30% (as unchanged drug)

Use: Labeled Indications

Treatment of itching associated with allergic conjunctivitis


Hypersensitivity to nedocromil or any component of the formulation

Dosing: Adult

Allergic conjunctivitis: Ophthalmic: 1-2 drops in each eye twice daily throughout the period of exposure to allergen

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Allergic conjunctivitis: Ophthalmic: Children ≥3 years: Refer to adult dosing.

Dosing: Renal Impairment

No dosage adjustment provided in manufacturer’s labeling. However, dosage adjustment unlikely due to low systemic absorption.

Dosing: Hepatic Impairment

No dosage adjustment provided in manufacturer’s labeling. However, dosage adjustment unlikely due to low systemic absorption.


For ophthalmic use only; do not allow tip of container to touch eye, surrounding structures, fingers, or other surfaces to avoid bacterial contamination.


Store at 2°C to 25°C (36°F to 77°F).

Drug Interactions

There are no known significant interactions.

Adverse Reactions


Central nervous system: Headache

Gastrointestinal: Unpleasant taste

Ocular: Burning, irritation, stinging

Respiratory: Nasal congestion

1% to 10%:

Ocular: Conjunctivitis, eye redness, photophobia

Respiratory: Asthma, rhinitis


Dosage form specific issues:

• Ophthalmic solution: Contains benzalkonium chloride, which may be absorbed by contact lenses; users of contact lenses should not wear them during periods of symptomatic allergic conjunctivitis.

Pregnancy Risk Factor


Pregnancy Considerations

There are no well-controlled studies in pregnant women. Animal studies show no evidence of teratogenicity or harm to fetus. Additionally, nedocromil has minimal systemic absorption.

Patient Education

• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)

• Patient may experience headache, burning, stinging, rhinitis, bad taste, or sensitivity to light. Have patient report immediately to prescriber vision changes, eye pain, or severe eye irritation (HCAHPS).

• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients.