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Nedocromil (Ophthalmic)

Medically reviewed by Drugs.com. Last updated on Jul 20, 2020.

Pronunciation

(ne doe KROE mil)

Index Terms

  • Nedocromil Sodium

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution, Ophthalmic, as sodium:

Alocril: 2% (5 mL) [contains benzalkonium chloride, disodium edta]

Brand Names: U.S.

  • Alocril

Pharmacologic Category

  • Mast Cell Stabilizer

Pharmacology

Inhibits the activation of and mediator release from a variety of inflammatory cell types associated with hypersensitivity reactions including eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets; it inhibits the release of histamine, leukotrienes, and slow-reacting substance of anaphylaxis.

Absorption

Low (<4%)

Excretion

Urine 70% (as unchanged drug); feces 30% (as unchanged drug)

Use: Labeled Indications

Allergic conjunctivitis: Treatment of itching associated with allergic conjunctivitis

Contraindications

Hypersensitivity to nedocromil or any component of the formulation

Dosing: Adult

Allergic conjunctivitis: Ophthalmic: 1 to 2 drops in each eye twice daily throughout the period of exposure to allergen

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Allergic conjunctivitis: Children ≥3 years and Adolescents: Ophthalmic: 1 to 2 drops in each eye twice daily throughout the period of exposure to allergen

Administration

For ophthalmic use only; do not allow tip of container to touch eye, surrounding structures, fingers, or other surfaces to avoid bacterial contamination. Use of contact lenses not recommended during periods of symptomatic allergic conjunctivitis.

Storage

Store at 2°C to 25°C (36°F to 77°F).

Drug Interactions

There are no known significant interactions.

Adverse Reactions

>10%:

Central nervous system: Headache (40%)

Gastrointestinal: Unpleasant taste

Ophthalmic: Burning sensation of eyes, eye irritation, stinging of eyes

Respiratory: Nasal congestion

1% to 10%:

Ophthalmic: Conjunctivitis, eye redness, photophobia

Respiratory: Asthma, rhinitis

Warnings/Precautions

Dosage form specific issues:

• Ophthalmic solution: Contains benzalkonium chloride, which may be absorbed by contact lenses; users of contact lenses should not wear them during periods of symptomatic allergic conjunctivitis.

Pregnancy Considerations

Nedocromil has minimal systemic absorption.

Patient Education

What is this drug used for?

• It is used to treat eye irritation.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Headache

• Burning

• Stinging

• Stuffy nose

• Bad taste

• Sensitivity to light

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Vision changes

• Eye pain

• Severe eye irritation

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.

Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.