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Dextromethorphan Hydrobromide / Benzocaine

Pronunciation: DEX-troe-meth-OR-fan HIGH-droe-BROE-mide/BEN-zoe-caine
Class: Nonnarcotic antitussive

Trade Names

Cepacol Dual Relief
- Spray 5 mg dextromethorphan and 5% benzocaine

Cepacol Ultra Sore Throat Plus Cough
- Lozenges 5 mg dextromethorphan and 7.5 mg benzocaine

- Lozenges 10 mg dextromethorphan and 15 mg benzocaine


Suppresses cough by central action on cough center in medulla.

Indications and Usage

Temporary relief of minor sore throat; temporary reduction in cough caused by minor throat and bronchial irritation.


MAOI therapy or for 2 wk after stopping MAOI therapy; allergy to local anesthetics (eg, butacaine, procaine) or any component of this product.

Dosage and Administration

Adults and Children 12 yr of age and older

PO 2 sprays every 4 h (max, 8 sprays/24 h).


Allow 2 lozenges (1 immediately after the other) to dissolve slowly in the mouth; may repeat every 4 h (max, 12 per 24 h).

Children (6 to 12 yr of age)

PO 1 spray every 4 h (max, 4 sprays/24 h).


Allow 1 lozenge to dissolve slowly in the mouth; may repeat every 4 h (max, 6 per 24 h).

Adults and children 6 yr of age and older

PO Dissolve 1 lozenge slowly in the mouth, do not chew. May be repeated every 4 h or as directed by health care provider.

General Advice

  • Cepacol Dual Relief
  • Spray into throat and then swallow.


Store at 59° to 86°F. Protect from moisture. Do not freeze.

Drug Interactions

MAOIs (eg, isocarboxazid)

Dextromethorphan is contraindicated with MAOIs.

Laboratory Test Interactions

None well documented.

Adverse Reactions


Drowsiness; dizziness.





Consult health care provider before use.


Consult health care provider before use.


Do not use Cepacol in children younger than 6 yr of age.

Chronic cough

Do not use in chronic cough such as occurs with smoking, emphysema, or asthma.

Excessive phlegm

Do not use with a cough that is accompanied by excessive phlegm.



Respiratory depression.

Patient Information

  • Advise patient to take as directed on the package insert or as advised by their health care provider.
  • Advise patient that if symptoms are not controlled not to increase the dose of medication or frequency of use but to inform their health care provider.
  • Instruct patient to notify their health care provider if any of the following occur: cough persists for longer than 1 wk or tends to recur; severe sore throat persists for more than 2 days, or if cough or sore throat is accompanied by fever, persistent headache, rash, swelling, nausea, or vomiting.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.