Skip to Content


Medically reviewed by Last updated on Jul 3, 2020.


(kris a BOR ole)

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Ointment, External:

Eucrisa: 2% (60 g, 100 g) [contains edetate (edta) calcium disodium, propylene glycol]

Brand Names: U.S.

  • Eucrisa

Pharmacologic Category

  • Phosphodiesterase-4 Enzyme Inhibitor, Topical
  • Topical Skin Product


Inhibits phosphodiesterase 4 (PDE-4) and results in increased intracellular cyclic adenosine monophosphate (cAMP) levels.


Hepatic to 2 inactive metabolites via hydrolysis and oxidation

Protein Binding


Use: Labeled Indications

Atopic dermatitis: Topical treatment of mild to moderate atopic dermatitis in adult and pediatric patients ≥3 months of age.


Hypersensitivity to crisaborole or any component of the formulation

Dosing: Adult

Atopic dermatitis: Topical: Apply a thin film to affected area(s) 2 times daily.

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Atopic dermatitis, mild to moderate: Infants ≥3 months, Children, and Adolescents: Topical: Apply a thin film to affected area(s) 2 times daily.


For topical use only; not for ophthalmic, oral, or intravaginal use.


Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F).

Drug Interactions

Riociguat: Crisaborole may enhance the hypotensive effect of Riociguat. Management: Riociguat is contraindicated with nonselective phosphodiesterase (PDE) inhibitors and PDE type 5 inhibitors. Other types of PDE inhibitors are not contraindicated, but caution is advised and patients should be monitored for hypotension. Monitor therapy

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

1% to 10%: Local: Application site pain (4%)

<1%: Dermatologic: Urticaria

Frequency not defined: Hypersensitivity: Hypersensitivity reaction

Postmarketing: Dermatologic: Allergic contact dermatitis


Concerns related to adverse effects:

• Hypersensitivity: Hypersensitivity reactions have been reported, including contact urticaria. Severe pruritus, swelling, or erythema (at the application site or at a distant site) may be indicative of hypersensitivity. Discontinue immediately for signs of hypersensitivity.

Monitoring Parameters

Signs of hypersensitivity

Pregnancy Considerations

Adverse effects were not observed in animal reproduction studies, except with high oral doses which also produced maternal toxicity.

Patient Education

What is this drug used for?

• It is used to treat eczema.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Burning

• Stinging

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Severe application site irritation

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.

Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Frequently Asked Questions