Skip to Content

Zerbaxa Approved for Hospital-Acquired Bacterial Pneumonia

TUESDAY, June 11, 2019 -- Zerbaxa (ceftolozane and tazobactam) has been approved for a new indication to treat hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP) in patients aged 18 years and older, the U.S. Food and Drug Administration announced yesterday.

In 2014, the FDA first approved Zerbaxa for treating complicated intra-abdominal infections and urinary tract infections. According to the manufacturer's prescribing information, Zerbaxa is administered in a recommended dosage regimen of a 1.5-g injection every eight hours by intravenous infusion for one hour. Treatment duration should be based on the infection site and severity and the patient's progress.

In a multinational, double-blind study of 726 patients hospitalized with HABP/VABP who were injected with Zerbaxa or another antibacterial drug, researchers found similar mortality and cure rates between the two drugs. The most commonly reported adverse reactions among patients treated with Zerbaxa included elevated liver enzyme levels, renal impairment or failure, and diarrhea.

The FDA notes that Zerbaxa should not be used in patients known to have serious hypersensitivity to the drug's components or to piperacillin/tazobactam or other antibacterial drugs in the beta lactam class.

Approval of Zerbaxa for this new indication was granted to Merck and Co.

More Information

© 2020 HealthDay. All rights reserved.

Posted: June 2019

Read this next

Flu, Pneumonia Vaccines Save Lives of Heart Failure Patients: Study

FRIDAY, Aug. 28, 2020 -- Flu and pneumonia vaccines lead to fewer hospital deaths among heart failure patients, a new study finds. "Our study provides further impetus for annual...

When a Nurse Becomes a COVID Patient: Her Tough Road Back

MONDAY, July 20, 2020 -- Nurse case manager Sharon Tapp recalls laying in a Bethesda, Md., hospital bed, feverishly ill from COVID-19, asking for a bedpan. Then, in what seemed...

HealthDay In-DepthThe AI Revolution: Giving Docs a Diagnostic Assist

MONDAY, June 8, 2020 -- Back before coronavirus took over the headlines, every week seemed to bring another report about artificial intelligence besting human doctors at...