Skip to Content

Whole-Genome Sequencing Is Accurate for Myeloid Cancers

WEDNESDAY, March 10, 2021 -- A streamlined whole-genome sequencing approach can provide rapid and accurate genomic profiling for acute myeloid leukemia (AML) or myelodysplastic syndromes, according to a study published in the March 11 issue of the New England Journal of Medicine.

Eric J. Duncavage, M.D., from the Washington University School of Medicine in St. Louis, and colleagues used a streamlined whole-genome sequencing approach to obtain genomic profiles for 263 patients with myeloid cancers, including 235 who had undergone cytogenetics analysis. The performance of whole-genome sequencing was analyzed by comparing results to findings from cytogenetic analysis and targeted sequencing.

The researchers found that all 40 recurrent translocations and 91 copy-number alterations that had been identified by cytogenetic analysis were detected by whole-genome sequencing. In addition, new clinically reportable genomic events were identified in 40 of 235 patients (17.0 percent). In prospective sequencing of samples obtained from 117 patients, new information was provided for 29 patients (24.8 percent), which changed the risk category for 19 patients (16.2 percent). There was a correlation seen for standard AML risk groups, defined by sequencing results instead of cytogenetic analysis, with clinical outcomes. Patients who had inconclusive results by cytogenetic analysis could be stratified by whole-genome sequencing into risk groups in which clinical outcomes were measurably different.

"Although our study focused on myeloid cancers, many of the advantages of whole-genome sequencing that we observed will directly apply to patients with other cancers," the authors write.

Illumina provided some of the reagents for prospective sequencing.

Abstract/Full Text (subscription or payment may be required)

© 2021 HealthDay. All rights reserved.

Read this next

Ahead of Tokyo Olympics, Japan Eases COVID-19 Restrictions

THURSDAY, June 17, 2021 -- A coronavirus state of emergency in Tokyo and six other areas will be downgraded when it expires on Sunday as new daily cases continue to decline, the...

Persistent Racial/Ethnic Disparities in Drowning Death Rates

THURSDAY, June 17, 2021 -- There are persistent racial/ethnic disparities in drowning death rates in the United States, according to research published in the June 18 issue of the...

U.S. Supreme Court Strikes Down Challenge to Affordable Care Act

THURSDAY, June 17, 2021 -- The landmark Affordable Care Act, which has expanded health care coverage to tens of millions of Americans, has withstood a third challenge before the...

More News Resources

Subscribe to our Newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.