Vertebral Fracture, AAC Score Predict Osteoporotic Fracture in Men
WEDNESDAY, March 17, 2021 -- Prevalent vertebral fractures (PVFx) and abdominal aortic calcification (AAC) are independent predictors of incident major osteoporotic fractures in older men, according to a study published online March 17 in the Journal of Bone and Mineral Research.
John T. Schousboe, M.D., from the Park Nicollet Clinic and HealthPartners Institute in Bloomington, Minnesota, and colleagues estimated the individual and joint associations of PVFx and AAC with incident major osteoporotic, hip, and clinical vertebral fractures among 5,365 older men enrolled in the Osteoporotic Fractures in Men study. Every four months, self-reports of incident fractures were solicited and were confirmed by clinical radiographic report review.
The researchers found that after accounting for conventional risk factors and competing mortality, the subdistribution hazard ratio for incident major osteoporotic fracture was 1.38 among men with an AAC-24 score ≥2 alone, 1.71 for men with PVFx alone, and 2.35 for men with both risk factors compared with men without PVFx and an AAC-24 score of 0 or 1. By including both risk factors, Wald statistics showed improved prediction model performance compared with including only AAC or only PVFx (chi-square, 17.3 and 8.5, respectively).
"Both abdominal aortic calcification and a prevalent vertebral fracture can be simultaneously and quickly detected on standard radiographs or lateral spine bone density images, and this may aid fracture risk assessment in older men who have either or both risk factors," Schousboe said in a statement.
© 2021 HealthDay. All rights reserved.
Posted: March 2021
Read this next
TUESDAY, April 13, 2021 -- Reimbursement for hospital charges is increasing faster than payments for surgeons performing hip fracture surgeries on Medicare beneficiaries,...
WEDNESDAY, March 31, 2021 -- The age-adjusted prevalence of osteoporosis at either the femur neck or lumbar spine or both was 12.6 percent among adults aged 50 years and older in...
MONDAY, March 29, 2021 -- In new joint guidelines issued by bone health experts, recommendations are presented for managing osteoporosis therapy in the context of COVID-19...
More News Resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our Newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.