US Study Confirms mRNA Vaccine Effectiveness Against SARS-CoV-2
TUESDAY, March 30, 2021 -- Messenger RNA (mRNA) COVID-19 vaccines are effective for preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, with 90 percent effectiveness for full immunization, according to research published in the March 29 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.
Mark G. Thompson, Ph.D., from the CDC COVID-19 Response Team, and colleagues routinely tested for SARS-CoV-2 infections every week during Dec. 14, 2020, to March 13, 2021, in prospective cohorts of health care personnel, first responders, and other essential and frontline workers in eight locations in the United States. Tests were conducted regardless of symptom status and onset of symptoms consistent with COVID-19.
Among 3,950 participants with no laboratory documentation of SARS-CoV-2 infection, 62.8 and 12.1 percent received both doses and only one dose of mRNA vaccine, respectively. The researchers found that among unvaccinated participants, 1.38 SARS-CoV-2 infections were confirmed per 1,000 person-days. In contrast, 0.04 and 0.19 infections were reported per 1,000 person-days among fully immunized participants (≥14 days after the second dose) and among partially immunized persons (≥14 days after the first dose), respectively. After adjustment for study site, the estimated mRNA vaccine effectiveness was 90 and 80 percent for full and partial immunization, respectively.
"This study shows that our national vaccination efforts are working," CDC Director Rochelle P. Walensky, M.D., M.P.H., said in a statement. "The authorized mRNA COVID-19 vaccines provided early, substantial real-world protection against infection for our nation's health care personnel, first responders, and other frontline essential workers."
One author disclosed financial ties to Pfizer.
© 2021 HealthDay. All rights reserved.
Posted: March 2021
Further Support and Information on COVID-19
Read this next
FRIDAY, April 16, 2021 -- For persons with a history of previous infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the neutralizing antibody titer is...
FRIDAY, April 16, 2021 -- Vaccinated Americans will probably need booster shots to guard against emerging coronavirus variants in the future, a White House adviser and Pfizer said...
FRIDAY, April 16, 2021 -- COVID-19 ups the risk for death with hemorrhagic stroke by more than twofold, according to a study published online April 14 in PLOS ONE. Vijay M....
More News Resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our Newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.