Skip to Content

Type 2 Diabetes Tied to Higher Risk for Parkinson Disease

TUESDAY, March 23, 2021 -- Type 2 diabetes mellitus (T2DM) is associated with an increased risk for Parkinson disease (PD), as well as more rapid PD progression, according to a review published online March 8 in Movement Disorders.

Harneek Chohan, from the Queen Mary University of London, and colleagues conducted a systematic literature review to identify studies investigating the association of T2DM with PD risk and progression. Then, summary data derived from genome-wide association studies were used to examine the causal effects of genetic liability toward T2DM on PD risk and progression.

The researchers found that pooled effect estimates showed that T2DM was associated with an increased risk for PD (odds ratio, 1.21), and there was some evidence that T2DM was associated with faster progression of motor symptoms (standardized mean difference, 0.55) and cognitive decline (standardized mean difference, −0.92). Using Mendelian randomization, there was supportive evidence for a causal effect of diabetes on PD risk (inverse-variance weighted method odds ratio, 1.08) and some evidence of an effect on motor progression (inverse-variance weighted method odds ratio, 1.10). However, there was no evidence of an association with cognitive progression.

"Careful screening for T2DM and early treatment of T2DM in PD patients may be advisable," the authors write.

Two authors disclosed financial ties to the pharmaceutical and biotechnology industries.

Abstract/Full Text

© 2021 HealthDay. All rights reserved.

Read this next

Gender, Race Affects Access to SGLT2-Inhibitor Therapy for T2DM

MONDAY, April 16, 2021 -- There are racial/ethnic, gender, and socioeconomic disparities apparent in access to sodium-glucose cotransporter 2 (SGLT2) inhibitor treatment for...

Diabetes Tied to Mortality, CV Events in Chronic Coronary Syndrome

THURSDAY, April 8, 2021 -- For patients with chronic coronary syndrome, the prevalence of diabetes varies but is associated with increased mortality and cardiovascular events,...

High Physical Activity, Low Air Pollution Exposure Cut T2DM Risk

TUESDAY, April 6, 2021 -- Higher levels of physical activity and lower levels of exposure to air pollution are associated with a lower risk for type 2 diabetes, according to a...

More News Resources

Subscribe to our Newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.