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Transient Improvement Found in Sedentary Time in CKD With Intervention

MONDAY, April 26, 2021 -- An intervention to reduce sedentary time and increase physical activity yields a transient improvement among patients with chronic kidney disease (CKD), according to a study published online April 22 in the Clinical Journal of the American Society of Nephrology.

Kate Lyden, Ph.D., from the University of Massachusetts in Amherst, and colleagues carried out the Sit Less, Interact, Move More intervention in a 24-week parallel-group, randomized trial among patients with CKD stages 2 to 5. Fifty-four participants in the intervention group underwent accelerometry at baseline and every four weeks to develop and monitor adherence to individualized plans targeting sedentary and stepping durations; 52 participants in the control group were given physical activity recommendations and underwent accelerometry at baseline and every eight weeks.

The researchers observed no change in sedentary and stepping durations in the control group. The maximum decrease in sedentary duration (−43 minutes/day) and number of steps/day (1,265) were observed in the intervention group at week 20. At week 24, these numbers were attenuated. Overall treatment effects between groups on sedentary and stepping durations and the number of steps/day were not significantly different in mixed-effect models. Significant reductions in secondary end points of body mass index (−1.1 kg/m2) and body fat percentage (−2.1 percent) were seen in the intervention group.

"While it is feasible to reduce sedentary duration in patients with CKD, additional co-interventions might be needed to sustain these effects long-term," a coauthor said in a statement.

Several authors disclosed financial ties to the pharmaceutical industry.

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