Tocilizumab Preserves Lung Function in Early Systemic Sclerosis
FRIDAY, April 23, 2021 -- Tocilizumab prevents progression of interstitial lung disease in patients with early systemic sclerosis (SSc), according to a study recently published in Arthritis & Rheumatology.
David Roofeh, M.D., from the University of Michigan Scleroderma Program in Ann Arbor, and colleagues performed a post-hoc analysis of data from a phase 3 trial that assessed the impact of tocilizumab on lung function preservation among patients with SSc and progressive skin disease. Treatment arms were stratified by the degree of radiographic lung involvement as mild (5 to 10 percent), moderate (>10 to 20 percent), or severe (>20 percent) interstitial lung disease. Spirometry was conducted at baseline and throughout the 48 weeks. High-resolution chest computed tomography was conducted at baseline and week 48. The analysis included 210 patients.
The researchers found that 65 percent of patients had interstitial lung disease, and of these patients, 77 percent had moderate-to-severe involvement defined by >10 percent lung involvement. Among those randomly assigned to tocilizumab, there was preservation of forced vital capacity over 48 weeks (least squared mean change in percent-predicted, −0.1) versus placebo (−6.3 percent). The mean declines in the percentage of predicted forced vital capacity in the tocilizumab arm at 48 weeks were −4.1 for mild, 0.7 for moderate, and 2.1 for severe quantitative interstitial lung disease versus −10.0, −5.7, and −6.7, respectively, in the placebo group. Independent of fibrosis severity, similar treatment-related preservation was seen.
"I hope this data suggests a possible paradigm shift in terms of treatment for these patients, providing an option of early detection and secondary-prevention, identifying the disease in the subclinical state, rather than later trying to reduce the impact of clinically significant disease," a coauthor said in a statement.
Several authors disclosed financial ties to the pharmaceutical, biopharmaceutical, and biotechnology industries.
© 2021 HealthDay. All rights reserved.
Posted: April 2021
Read this next
WEDNESDAY, March 31, 2021 -- Source of payment is strongly associated with radiograph classification of black lung disease, according to a study published online March 29 in the...
THURSDAY, Jan. 14, 2021 -- Inhaled treprostinil improves exercise capacity in patients with pulmonary hypertension due to interstitial lung disease, according to a study published...
TUESDAY, Nov. 24, 2020 -- In an official American Thoracic Society clinical practice guideline, published in the Nov. 15 issue of the American Journal of Respiratory and Critical...
More News Resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our Newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.