Timing of Antimicrobial Prophylaxis Examined for C-Section
TUESDAY, Dec. 29, 2020 -- For women undergoing cesarean section, the risk for surgical site infection (SSI) is not increased when surgical antimicrobial prophylaxis (SAP) is administered after umbilical cord clamping rather than before incision, according to a study published online Dec. 22 in Antimicrobial Resistance & Infection Control.
Rami Sommerstein, M.D., from Bern University Hospital in Switzerland, and colleagues conducted a cohort study involving 55,901 patients from 75 participating Swiss hospitals from 2009 to 2018. The association between SAP administration relative to incision and clamping and the SSI rate was examined.
The researchers found that in 47.2 and 52.8 percent of patients, SAP was administered before incision and after clamping, respectively. No difference was observed in the rate of SSI for those receiving SAP before incision versus after clamping (1.6 versus 1.7 percent, respectively; P = 0.759). The investigators observed no significant association between SAP administration after clamping versus before incision and increased SSI rate (adjusted odds ratio, 1.14; 95 percent confidence interval, 0.96 to 1.36; P = 0.144).
"These results challenge the latest World Health Organization recommendation which extends the time window of SAP from 60 minutes to 120 minutes prior to incision but does not consider administration after clamping," the authors write.
© 2021 HealthDay. All rights reserved.
Posted: December 2020
Read this next
THURSDAY, Jan. 14, 2021 -- Exercise during the first trimester of pregnancy reduces the risks for abnormal glucose screening and gestational diabetes mellitus (GDM), according to...
WEDNESDAY, Jan. 13, 2021 -- Women with pregnancy after versus before a multiple sclerosis (MS) diagnosis have fewer children and at an older age, according to a study published in...
WEDNESDAY, Jan. 13, 2021 -- Use of a higher hemoglobin transfusion threshold does not lower the risk for death or neurodevelopmental impairment at 22 to 26 months of age among...
More News Resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our Newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.