Study Explores Oxytocin Use in Active Phase of Induced Labor
THURSDAY, April 15, 2021 -- For women stimulated with intravenous oxytocin during the latent phase of induced labor, discontinuation of oxytocin in the active phase of labor may lead to a small increase in the rate of cesarean section but a decrease in fetal heart rate abnormalities, according to a study published online April 14 in The BMJ.
Sidsel Boie, M.D., from Randers Regional Hospital in Denmark, and colleagues randomly assigned 1,200 women from nine hospitals in Denmark and one in the Netherlands, stimulated with intravenous oxytocin during the latent phase of induced labor, to have their oxytocin stimulation discontinued or continued in the active phase of labor (607 and 593 women, respectively).
The researchers found that the rates of cesarean section were 16.6 and 14.2 percent in the discontinued and continued groups, respectively (relative risk, 1.17; 95 percent confidence interval, 0.90 to 1.53). The cesarean section rate was 7.5 and 0.6 percent in the discontinued and continued groups, respectively, among 94 parous women with no previous cesarean section (relative risk, 11.6; 95 percent confidence interval, 1.15 to 88.7). Discontinuation correlated with a significantly longer duration of labor, reduced risk for hyperstimulation, and reduced risk for fetal heart rate abnormalities; similar rates of other adverse maternal and neonatal outcomes were seen between the groups.
"In a setting where monitoring of the fetal condition and the uterine contractions can be guaranteed, routine discontinuation of oxytocin stimulation may lead to a small increased risk of caesarean section but a significantly reduced risk of uterine hyperstimulation and abnormal fetal heart rate," the authors write.
© 2021 HealthDay. All rights reserved.
Posted: April 2021
Read this next
MONDAY, May 10, 2021 -- Children born preterm have considerable rates of severe/moderate neurodevelopmental disabilities at age 5 years, according to a study published online...
MONDAY, May 10, 2021 -- Nitrate in drinking water is associated with increased odds of spontaneous preterm birth, according to a study published online May 5 in Environmental...
THURSDAY, May 6, 2021 -- Prenatal cannabis use disorder (CUD) is associated with higher odds of major adverse neonatal outcomes, according to a study published online April 22 in...
More News Resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our Newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.