Stem Cell Transplant Reviewed for Peripheral T-Cell Lymphoma
THURSDAY, June 10, 2021 -- For patients with refractory or relapsed peripheral T-cell lymphoma (R/R-PTCL), three- and five-year overall survival (OS) and progression-free survival (PFS) are similar with allogeneic or autologous hematopoietic stem cell transplant (HSCT), but transplant-related mortality (TRM) is higher with allogeneic HSCT, according to a review published online May 27 in JAMA Network Open.
Jun Du, M.D., from the Chinese Academy of Medical Sciences and Peking Union Medical College in Tianjin, China, and colleagues conducted a systematic review of the literature and meta-analysis to compare the effectiveness and safety of allogeneic HSCT versus autologous HSCT among patients with R/R-PTCL. Thirty trials were included in the meta-analysis, with 880 and 885 patients undergoing allogeneic and autologous HSCT, respectively.
The researchers found that the three-year OS and PFS were 50 and 42 percent, respectively; five-year OS and PFS were 54 and 48 percent, respectively; and three-year TRM was 32 percent in the allogeneic HSCT group. The three-year OS and PFS were 55 and 41 percent, respectively; five-year OS and PFS were 53 and 40 percent, respectively; and three-year TRM was 7 percent in the autologous HSCT group.
"The data from this meta-analysis provide evidence that for select patients with PTCL, both autologous HSCT and allogeneic HSCT may be a potentially effective approach to treatment," write the authors of an accompanying editorial. "This meta-analysis falls short of providing a rigorous, risk-segmented analysis of which modality is more likely to be most effective for a particular patient."
© 2021 HealthDay. All rights reserved.
Posted June 2021
Read this next
MONDAY, Feb. 8, 2021 -- Cell-based gene therapy Breyanzi (lisocabtagene maraleucel) has been approved to treat adults with certain types of large B-cell lymphoma who have not...
WEDNESDAY, Dec. 9, 2020 -- Axicabtagene ciloleucel (axi-cel), an autologous anti-CD19 chimeric antigen receptor T-cell therapy, is promising for the treatment of...
FRIDAY, Nov. 20, 2020 -- For patients with primary central nervous system lymphoma (PCNSL), the incidence of venous thromboembolism (VTE) and major bleeding is high, according to...
More News Resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our Newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.