Skip to Content

Sotatercept Reduces Pulmonary Vascular Resistance in PAH

WEDNESDAY, March 31, 2021 -- For patients receiving background therapy for pulmonary arterial hypertension, treatment with sotatercept results in a reduction in pulmonary vascular resistance, according to a study published in the April 1 issue of the New England Journal of Medicine.

Marc Humbert, M.D., Ph.D., from Hôpital Bicêtre in Paris, and colleagues conducted the 24-week placebo-controlled period of a multicenter phase 2 trial in which 106 adults receiving background therapy for pulmonary arterial hypertension were randomly assigned to receive subcutaneous sotatercept at a dose of 0.3 or 0.7 mg/kg body weight every three weeks or placebo. An 18-month active-drug extension period for this trial is currently ongoing.

The researchers found that the least-squares mean difference in the change from baseline to week 24 in pulmonary vascular resistance between the sotatercept 0.3-mg group and the placebo group was −145.8 dyn/sec/cm-5; the corresponding difference between the sotatercept 0.7-mg group and the placebo group was −239.5 dyn/sec/cm-5. At 24 weeks, the least-squares mean difference in the change from baseline in six-minute walk distance between the sotatercept 0.3-mg and placebo groups was 29.4 m; the corresponding difference between the sotatercept 0.7-mg and placebo groups was 21.4 m. There was also an association seen for sotatercept with a decrease in N-terminal pro-B-type natriuretic peptide levels. The most common hematologic adverse events were thrombocytopenia and an increased hemoglobin level.

"Treatment with sotatercept reduced pulmonary vascular resistance among patients with pulmonary arterial hypertension who were receiving stable background therapy, including prostacyclin infusion therapy," the authors write.

The study was funded by Acceleron Pharma, the manufacturer of sotatercept.

Abstract/Full Text (subscription or payment may be required)

Editorial (subscription or payment may be required)

© 2021 HealthDay. All rights reserved.

Read this next

Inhaled Treprostinil Beneficial in Pulmonary Hypertension

THURSDAY, Jan. 14, 2021 -- Inhaled treprostinil improves exercise capacity in patients with pulmonary hypertension due to interstitial lung disease, according to a study published...

More News Resources

Subscribe to our Newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.